Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Сен. 10, 2024

Impaired cognitive ability is one of the most frequently reported neuropsychiatric symptoms in post-COVID phase among patients. It unclear whether this condition related to structural or functional brain changes.

Язык: Английский

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Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4128 - 4128

Опубликована: Июль 15, 2024

Background/Objectives: The aim of this study was to evaluate brain metabolism using MR spectroscopy (MRS) after recovery from Coronavirus disease (COVID-19) and test the impact severity on metabolites. Methods: We performed MRS 81 individuals (45 males, 36 females, aged 40–60), who had normal MRI findings recovered COVID-19, classifying them into mild (17), moderate (36), severe (28) groups based during acute phase. employed two-dimensional spectroscopic imaging above corpus callosum, focusing choline (Cho), creatine (Cr), N-acetylaspartate (NAA). analyzed Cho/Cr NAA/Cr ratios as well absolute concentrations water an internal reference. Results: Results indicated that ratio higher with increasing severity, while Cho showed no significant differences across groups. Notably, Cr NAA levels were significantly lower in patients disease. Conclusions: These suggest COVID-19 phase is associated changes metabolism, marked by increase a reduction levels, reflecting substantial metabolic alterations post-recovery.

Язык: Английский

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Limbic system damage following SARS-CoV2 infection

Brain Communications, Год журнала: 2023, Номер 5(6)

Опубликована: Янв. 1, 2023

The World Health Organization declared end to COVID-19 pandemic on May 5, 2023.Certainly, this did not mean that SARS-CoV2 would be a concern in our daily medical practice.As neurologists, we may even have seen the major neurological disease burden caused by virus regarding long-term sequelae survivors.SARS-CoV2 is neurotropic virus.Although direct evidence present, thought enter neural tissue either hematogenously or through peripheral nerve endings and access brain via retrograde transport.The symptoms of long COVID arise from invasion (1).There was remarkable research article Brain Communications June 2023 Thomasson et al. limbic system damage following infection (2).They delicately showed moderately severely affected patients displayed impaired emotion recognition which also associated with decreased memory olfactory abilities.Moreover, they identified altered functional connectivity patterns involving cortico-subcorticalcerebellar networks at 6-9 months post-infection.From very beginning, has been under spotlight since loss olfaction one presenting infection.Subsequent studies shown metabolism, perfusion, structure structures after .This study adds these data showing behavioral consequences changes simultaneously, COVID-19.The main question wonder about point whether there were accompanying structural sites brain.The authors tried assess issue volume-based morphometric (VBM) analyses.They reported no differences anatomical images could patterns.We like out absence control group makes it difficult

Язык: Английский

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Cognitive Function and Brain Structure in COVID-19 Survivors: The Role of Persistent Symptoms

Behavioural Brain Research, Год журнала: 2024, Номер 476, С. 115283 - 115283

Опубликована: Окт. 3, 2024

Persistent COVID-19 symptoms post-acute state have been shown to a significant negative impact on brain structure and function. In this study, we conducted magnetic resonance imaging (MRI) of the whole in 43 working-age adults (mean age: 44.79±10.80; range: 24-65 years) with history (731.17±312.41 days post-diagnosis), also assessed their cognitive function (processing speed, attention, working memory, executive function, recognition memory), mental health, sleep quality. MRI data were processed using FSL derive regional volumes for bilateral nucleus accumbens, caudate, pallidum, putamen, thalamus, amygdala, hippocampus, total grey matter, white cerebral spinal fluid volume, analysed relation persistent symptom load, Higher load was significantly associated smaller putamen lower response accuracy memory tasks, as well longer time complete task, poorer health Smaller fully mediated relationship between Further research is required confirm whether reduced volume its association poor persists survivors long term.

Язык: Английский

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COVID-19: ramifications of the pandemic on mental health and substance abuse

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Июль 31, 2024

To explore the ramifications of COVID-19 pandemic on Mental Health and Substance Use.

Язык: Английский

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Transient MRI changes and neurological deterioration in glioblastoma upon SARS-CoV-2 infection

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(9)

Опубликована: Сен. 28, 2024

Язык: Английский

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