Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19
Anar Isman,
Andy Nyquist,
Bailey Strecker
и другие.
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
36, С. 100733 - 100733
Опубликована: Фев. 2, 2024
A
subset
of
patients
experiences
persistent
fatigue
symptoms
after
COVID-19,
and
may
develop
long
COVID,
which
is
characterized
by
lasting
systemic
symptoms.
No
treatments
for
this
condition
have
been
validated
are
urgently
warranted.
In
pilot
study,
we
assessed
whether
treatment
with
low-dose
naltrexone
(LDN,
4.5
mg/day)
supplementation
NAD
+
through
iontophoresis
patches
could
improve
quality
life
in
36
moderate/severe
COVID-19.
We
detected
a
significant
increase
from
baseline
SF-36
survey
scores
12
weeks
(mean
total
score
36.5
[SD:
15.6]
vs.
52.1
[24.8];
p
<
0.0001),
suggestive
improvement
life.
Furthermore,
participants
scored
significantly
lower
on
the
Chalder
scale
(baseline:
25.9
[4.6],
weeks:
17.4
[9.7];
0.0001).
found
52
%
to
be
responders
treatment.
Treatment
was
generally
safe,
mild
adverse
events
previously
reported
LDN,
managed
dose
adjustments.
The
were
associated
mild,
short-lived
skin
irritation
25
patients.
Our
data
suggest
LDN
NAD+
safe
beneficial
Larger
randomized
controlled
trials
will
confirm
our
determine
patient
subpopulations
might
benefit
most
strategy.
Язык: Английский
Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study
Опубликована: Апрель 1, 2024
Background:
Online
survey-based
observational
cross-sectional
study
aimed
at
elucidating
experience
and
attitudes
of
unstructured
population
regarding
diagnostic
imaging.
Methods:
Invitations
to
participate
were
distributed
using
mixed-mode
design
deidentified
residents
aged
18
years
older.
Main
outcome
measures
included
morbidity
structure
incidence
imaging
administrations.
Results:
Respondents
(n
=
1069)
44.3
±
14.4
years;
32.8%
suffered
from
cardiovascular
diseases
(CVD);
9.5%
had
chronic
respiratory
pathology;
28.9%
considered
themselves
healthy.
with
COVID-19
history
(49.7%)
reported
higher
rates
computed
tomography
(CT)
(p
&lt;
.0001),
magnetic
resonance
(MRI)
.001),
ultrasound
.05).
in
CVD
respondents
shifted
administrations
towards
CT
MRI
Every
tenth
respondent
received
MRI,
CT,
on
paid
basis;
29.0%
could
not
pay
for
procedures;
13.1%
unavailable
MRI.
Professional
status
significantly
affected
the
pattern
modalities
availability
differed
between
urban
rural
areas
.0001).
History
technogenic
events
predisposed
responders
overestimate
value
fluorography
Conclusions:
Preparedness
future
pandemics
requires
development
community-based
outreach
programs
focusing
people's
awareness
medical
safety
value.
Язык: Английский
Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study
Diagnostics,
Год журнала:
2024,
Номер
14(12), С. 1269 - 1269
Опубликована: Июнь 15, 2024
(1)
Background:
An
online
survey-based
observational
cross-sectional
study
aimed
at
elucidating
the
experience
and
attitudes
of
an
unstructured
population
regarding
diagnostic
imaging.
(2)
Methods:
Invitations
to
participate
were
distributed
using
mixed-mode
design
deidentified
residents
aged
18
years
older.
Main
outcome
measures
included
morbidity
structure
incidence
imaging
administrations.
(3)
Results:
Respondents
(n
=
1069)
44.3
±
14.4
years;
32.8%
suffered
from
cardiovascular
diseases
(CVD);
9.5%
had
chronic
respiratory
pathology;
28.9%
considered
themselves
healthy.
with
COVID-19
history
(49.7%)
reported
higher
rates
computed
tomography
(CT)
(p
<
0.0001),
magnetic
resonance
(MRI)
0.001),
ultrasound
0.05).
in
CVD
respondents
shifted
administrations
towards
CT
MRI
Every
tenth
respondent
received
MRI,
CT,
on
a
paid
basis;
29.0%
could
not
pay
for
procedures;
13.1%
unavailable
MRI.
Professional
status
significantly
affected
pattern
modalities
availability
differed
between
urban
rural
areas
0.0001).
History
technogenic
events
predisposed
responders
overestimate
value
fluorography
(4)
Conclusions:
Preparedness
future
pandemics
requires
development
community-based
outreach
programs
focusing
people’s
awareness
medical
safety
value.
Язык: Английский
Special Issue “Clinical Consequences of COVID-19”: Taking a Look at Complexity
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(24), С. 7756 - 7756
Опубликована: Дек. 18, 2023
The
consequences
of
SARS-CoV-2
infection
are
far
from
being
fully
understood
or
accounted
for
[...].
Язык: Английский