Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100733 - 100733

Published: Feb. 2, 2024

A subset of patients experiences persistent fatigue symptoms after COVID-19, and may develop long COVID, which is characterized by lasting systemic symptoms. No treatments for this condition have been validated are urgently warranted. In pilot study, we assessed whether treatment with low-dose naltrexone (LDN, 4.5 mg/day) supplementation NAD + through iontophoresis patches could improve quality life in 36 moderate/severe COVID-19. We detected a significant increase from baseline SF-36 survey scores 12 weeks (mean total score 36.5 [SD: 15.6] vs. 52.1 [24.8]; p < 0.0001), suggestive improvement life. Furthermore, participants scored significantly lower on the Chalder scale (baseline: 25.9 [4.6], weeks: 17.4 [9.7]; 0.0001). found 52 % to be responders treatment. Treatment was generally safe, mild adverse events previously reported LDN, managed dose adjustments. The were associated mild, short-lived skin irritation 25 patients. Our data suggest LDN NAD+ safe beneficial Larger randomized controlled trials will confirm our determine patient subpopulations might benefit most strategy.

Language: Английский

---

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Published: April 1, 2024

Background: Online survey-based observational cross-sectional study aimed at elucidating experience and attitudes of unstructured population regarding diagnostic imaging. Methods: Invitations to participate were distributed using mixed-mode design deidentified residents aged 18 years older. Main outcome measures included morbidity structure incidence imaging administrations. Results: Respondents (n = 1069) 44.3 ± 14.4 years; 32.8% suffered from cardiovascular diseases (CVD); 9.5% had chronic respiratory pathology; 28.9% considered themselves healthy. with COVID-19 history (49.7%) reported higher rates computed tomography (CT) (p &amp;lt; .0001), magnetic resonance (MRI) .001), ultrasound .05). in CVD respondents shifted administrations towards CT MRI Every tenth respondent received MRI, CT, on paid basis; 29.0% could not pay for procedures; 13.1% unavailable MRI. Professional status significantly affected the pattern modalities availability differed between urban rural areas .0001). History technogenic events predisposed responders overestimate value fluorography Conclusions: Preparedness future pandemics requires development community-based outreach programs focusing people&#039;s awareness medical safety value.

Language: Английский

---

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Diagnostics, Journal Year: 2024, Volume and Issue: 14(12), P. 1269 - 1269

Published: June 15, 2024

(1) Background: An online survey-based observational cross-sectional study aimed at elucidating the experience and attitudes of an unstructured population regarding diagnostic imaging. (2) Methods: Invitations to participate were distributed using mixed-mode design deidentified residents aged 18 years older. Main outcome measures included morbidity structure incidence imaging administrations. (3) Results: Respondents (n = 1069) 44.3 ± 14.4 years; 32.8% suffered from cardiovascular diseases (CVD); 9.5% had chronic respiratory pathology; 28.9% considered themselves healthy. with COVID-19 history (49.7%) reported higher rates computed tomography (CT) (p < 0.0001), magnetic resonance (MRI) 0.001), ultrasound 0.05). in CVD respondents shifted administrations towards CT MRI Every tenth respondent received MRI, CT, on a paid basis; 29.0% could not pay for procedures; 13.1% unavailable MRI. Professional status significantly affected pattern modalities availability differed between urban rural areas 0.0001). History technogenic events predisposed responders overestimate value fluorography (4) Conclusions: Preparedness future pandemics requires development community-based outreach programs focusing people’s awareness medical safety value.

Language: Английский

---

Special Issue “Clinical Consequences of COVID-19”: Taking a Look at Complexity

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(24), P. 7756 - 7756

Published: Dec. 18, 2023

The consequences of SARS-CoV-2 infection are far from being fully understood or accounted for [...].

Language: Английский

---