Inflammation unleashed: The role of pyroptosis in chronic liver diseases

International Immunopharmacology, Год журнала: 2024, Номер 141, С. 113006 - 113006

Опубликована: Авг. 29, 2024

Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.

Язык: Английский

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Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Опубликована: Апрель 1, 2024

Background: Online survey-based observational cross-sectional study aimed at elucidating experience and attitudes of unstructured population regarding diagnostic imaging. Methods: Invitations to participate were distributed using mixed-mode design deidentified residents aged 18 years older. Main outcome measures included morbidity structure incidence imaging administrations. Results: Respondents (n = 1069) 44.3 ± 14.4 years; 32.8% suffered from cardiovascular diseases (CVD); 9.5% had chronic respiratory pathology; 28.9% considered themselves healthy. with COVID-19 history (49.7%) reported higher rates computed tomography (CT) (p < .0001), magnetic resonance (MRI) .001), ultrasound .05). in CVD respondents shifted administrations towards CT MRI Every tenth respondent received MRI, CT, on paid basis; 29.0% could not pay for procedures; 13.1% unavailable MRI. Professional status significantly affected the pattern modalities availability differed between urban rural areas .0001). History technogenic events predisposed responders overestimate value fluorography Conclusions: Preparedness future pandemics requires development community-based outreach programs focusing people's awareness medical safety value.

Язык: Английский

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Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

Diagnostics, Год журнала: 2024, Номер 14(12), С. 1269 - 1269

Опубликована: Июнь 15, 2024

(1) Background: An online survey-based observational cross-sectional study aimed at elucidating the experience and attitudes of an unstructured population regarding diagnostic imaging. (2) Methods: Invitations to participate were distributed using mixed-mode design deidentified residents aged 18 years older. Main outcome measures included morbidity structure incidence imaging administrations. (3) Results: Respondents (n = 1069) 44.3 ± 14.4 years; 32.8% suffered from cardiovascular diseases (CVD); 9.5% had chronic respiratory pathology; 28.9% considered themselves healthy. with COVID-19 history (49.7%) reported higher rates computed tomography (CT) (p < 0.0001), magnetic resonance (MRI) 0.001), ultrasound 0.05). in CVD respondents shifted administrations towards CT MRI Every tenth respondent received MRI, CT, on a paid basis; 29.0% could not pay for procedures; 13.1% unavailable MRI. Professional status significantly affected pattern modalities availability differed between urban rural areas 0.0001). History technogenic events predisposed responders overestimate value fluorography (4) Conclusions: Preparedness future pandemics requires development community-based outreach programs focusing people’s awareness medical safety value.

Язык: Английский

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SARS-CoV-2 infection increases thrombus load in coronary arteries of patients with AMI: a retrospective study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Background:There is a lack of national and international literature on the effect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection thrombosis or increased risk in patients with myocardial infarction(AMI). Therefore, aim this retrospective study was to investigate thrombus load within coronary arteries SARS-CoV-2 combined AMI provide data support for clinical management Coronavirus Disease 2019 (COVID-19) AMI. Methods:A total 174 cardiovascular internal medicine department Zhangjiajie People's Hospital Sangzhi County were collected from 01 December 2022 June 2023, divided into two groups according whether not they infected SARS-CoV-2. Among them, 90 cases COVID-19 group, 84 non-COVID-19 group. And such as gender, age, hypertension, diabetes mellitus, hyperlipidemia, criminal vascularity, grading retrospectively analyzed these patients. Results:It found that there no significant difference between terms diabetes, hyperlipidaemia infarcted offender vessel. Of 64 formed thrombi, which culprit vessels right (RCA) 37 (57.8%), left anterior descending artery (LAD) 23 (35.9%), main artery/left circumflex (LM/LCX) 4 (6.3%). In 49 28 (57.1%) coronary, 11 (22.4%) descending, 10 (20.4%) main/revolving branches. Conclusion:In conclusion, leads an tendency be state high thrombotic load. interestingly, RCA more prone formation than LAD, LCX LM.

Язык: Английский

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