Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism DOI Creative Commons
Arwa Ishaq A. Khayyat,

Altaf Alabdali,

Mona Alonazi

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 27, 2025

Background/objectives Oxidative stress, organ impairments, and gastrointestinal abnormalities are the most common systemic dysfunctions that accompanied neurodevelopmental condition, Autism Spectrum Disorder (ASD). Emerging evidence suggests increased propionic acid (PPA) levels contribute to ASD pathophysiology through oxidative neuroinflammation disruption of gut-liver-brain axis. Thanks its strong anti-inflammatory antioxidant potencies, luteolin, has shown be promising in alleviating these effects. This study investigated therapeutic protective effects luteolin a PPA-induced rodent model by assessing intestinal permeability, liver kidney dysfunction biomarkers. Methods Fifty young male albino rats were divided into five groups: control, PPA-treated, luteolin-treated, (PPA followed luteolin), (luteolin PPA). stress markers (GSH, lipid peroxides, GST, SOD, catalase), serum zonulin, enzymes (ALT, AST, ALP) renal function (urea nitrogen, creatinine) investigated. ROC analysis evaluated diagnostic potential biomarkers, while Spearman correlation explored interrelationships among parameters. Results PPA administration significantly reduced defenses, including GSH, catalase, increasing peroxidation inducing hepatic dysfunction, as evidenced elevated ALT, ALP, urea creatinine levels, along with zonulin levels. Luteolin intervention effectively reversed alterations restoring capacity, lowering improving function. demonstrated high accuracy (AUC = 1.000) for PPA-treated group, treatment enhanced biomarker sensitivity specificity. revealed negative correlations between antioxidants ( p < 0.001) positive liver/kidney indicators 0.001), further confirming impact PPA. Conclusion alleviated restored liver, kidney, barrier functions model. These findings underscored natural ASD-related dysfunctions. Further clinical studies needed evaluate translational applicability management.

Язык: Английский

Uraemic syndrome following acute renal failure in horses DOI Creative Commons
Gaby van Galen

Equine Veterinary Education, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

Процитировано

1
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna,

Adina Boulos,

Melany Abreu

и другие.

European journal of ecology, biology and agriculture., Год журнала: 2025, Номер 2(2), С. 30 - 46

Опубликована: Март 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Язык: Английский

Процитировано

0
Impact of Gut Microbiome Modulation on Uremic Toxin Reduction in Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis DOI Open Access

Renata Cedillo-Flores,

Miguel Ángel Cuevas‐Budhart, Iván Cavero‐Redondo

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1247 - 1247

Опубликована: Апрель 3, 2025

Background/Objectives: Chronic kidney disease is associated with increased intestinal barrier permeability, leading to heightened inflammation and oxidative stress. These changes contribute complications such as cardiovascular disease, anemia, altered mineral metabolism, CKD progression. Interventions using prebiotics, probiotics, synbiotics may mitigate dysbiosis improve function, Under this premise, the objective of network meta-analysis was evaluate effect in reducing uremic toxins produced by gut microbiota patients. Methods: A systematic review randomized clinical trials (RCTs) performed following databases: Web Science, Scopus, Cochrane Register Controlled Trials, PubMed published between 2019 2023. The analysis focused on use patients at stages 3 5, per KDIGO guidelines, their association reductions Indoxyl Sulfate, p-Cresyl urea, creatinine. risk bias assessed tool (RoB 2), evaluations conducted independently two reviewers, a third consulted for disagreements. study follows PRISMA statement. Results: studies included 331 patients, primarily male, across 3a 5. interventions positively impacted composition, free total Sulfate (SUCRA: 72.6% 66.2, respectively) indoxyl sulfate 88.5% 83.1%). Conclusions: findings suggest that modulating through these can effectively reduce specific toxins. However, further are necessary better understand modulation its impact bacterial composition (PROSPERO number: CRD42023438901).

Язык: Английский

Процитировано

0
Drivers and mechanisms of cognitive decline in chronic kidney disease DOI
Giovambattista Capasso, Casper Franssen, Alessandra F. Perna

и другие.

Nature Reviews Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0
Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis DOI Creative Commons

Run-Xi Wang,

Hong-Bing Zhou, Jin Gao

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 28, 2025

The intricate pathogenesis of renal fibrosis necessitates identifying biomarkers at various stages to facilitate targeted therapeutic interventions, which would enhance patient survival rates and significantly improve prognosis. We investigated the changes in gut microbiota serum metabolites during early, middle, late rats using 16S rDNA sequencing UPLC-QTOF/MS-based metabolomics. identified 5, 21, 14 potential microbial markers 19, 23, 31 metabolic MOD1, MOD2, MOD4 groups, respectively. Bifidobacterium was as a shared marker between MOD1 MOD2 groups; Prevotellaceae_NK3B31_group Bacteroides were groups. pathways arachidonic acid metabolism retinol found play significant role modulation 1, 2, 4 weeks. Notably, 8,9-EET 5(S)-HPETE within these emerged critical determinants influencing fibrosis. Our findings demonstrated that severity is associated with dysbiosis alterations metabolites.

Язык: Английский

Процитировано

0
Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism DOI Creative Commons
Arwa Ishaq A. Khayyat,

Altaf Alabdali,

Mona Alonazi

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 27, 2025

Background/objectives Oxidative stress, organ impairments, and gastrointestinal abnormalities are the most common systemic dysfunctions that accompanied neurodevelopmental condition, Autism Spectrum Disorder (ASD). Emerging evidence suggests increased propionic acid (PPA) levels contribute to ASD pathophysiology through oxidative neuroinflammation disruption of gut-liver-brain axis. Thanks its strong anti-inflammatory antioxidant potencies, luteolin, has shown be promising in alleviating these effects. This study investigated therapeutic protective effects luteolin a PPA-induced rodent model by assessing intestinal permeability, liver kidney dysfunction biomarkers. Methods Fifty young male albino rats were divided into five groups: control, PPA-treated, luteolin-treated, (PPA followed luteolin), (luteolin PPA). stress markers (GSH, lipid peroxides, GST, SOD, catalase), serum zonulin, enzymes (ALT, AST, ALP) renal function (urea nitrogen, creatinine) investigated. ROC analysis evaluated diagnostic potential biomarkers, while Spearman correlation explored interrelationships among parameters. Results PPA administration significantly reduced defenses, including GSH, catalase, increasing peroxidation inducing hepatic dysfunction, as evidenced elevated ALT, ALP, urea creatinine levels, along with zonulin levels. Luteolin intervention effectively reversed alterations restoring capacity, lowering improving function. demonstrated high accuracy (AUC = 1.000) for PPA-treated group, treatment enhanced biomarker sensitivity specificity. revealed negative correlations between antioxidants ( p < 0.001) positive liver/kidney indicators 0.001), further confirming impact PPA. Conclusion alleviated restored liver, kidney, barrier functions model. These findings underscored natural ASD-related dysfunctions. Further clinical studies needed evaluate translational applicability management.

Язык: Английский

Процитировано

0