PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna, Adina Boulos, Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Uraemic syndrome following acute renal failure in horses DOI Creative Commons
Gaby Van Galen

Equine Veterinary Education, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

1
Impact of Gut Microbiome Modulation on Uremic Toxin Reduction in Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis DOI Open Access

Renata Cedillo-Flores,

Miguel Ángel Cuevas‐Budhart, Iván Cavero‐Redondo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1247 - 1247

Published: April 3, 2025

Background/Objectives: Chronic kidney disease is associated with increased intestinal barrier permeability, leading to heightened inflammation and oxidative stress. These changes contribute complications such as cardiovascular disease, anemia, altered mineral metabolism, CKD progression. Interventions using prebiotics, probiotics, synbiotics may mitigate dysbiosis improve function, Under this premise, the objective of network meta-analysis was evaluate effect in reducing uremic toxins produced by gut microbiota patients. Methods: A systematic review randomized clinical trials (RCTs) performed following databases: Web Science, Scopus, Cochrane Register Controlled Trials, PubMed published between 2019 2023. The analysis focused on use patients at stages 3 5, per KDIGO guidelines, their association reductions Indoxyl Sulfate, p-Cresyl urea, creatinine. risk bias assessed tool (RoB 2), evaluations conducted independently two reviewers, a third consulted for disagreements. study follows PRISMA statement. Results: studies included 331 patients, primarily male, across 3a 5. interventions positively impacted composition, free total Sulfate (SUCRA: 72.6% 66.2, respectively) indoxyl sulfate 88.5% 83.1%). Conclusions: findings suggest that modulating through these can effectively reduce specific toxins. However, further are necessary better understand modulation its impact bacterial composition (PROSPERO number: CRD42023438901).

Language: Английский

Citations

0
Drivers and mechanisms of cognitive decline in chronic kidney disease DOI
Giovambattista Capasso, Casper Franssen, Alessandra Perna

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis DOI Creative Commons

Run-Xi Wang,

Hong-Bing Zhou, Jin Gao

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Introduction The intricate pathogenesis of renal fibrosis necessitates identifying biomarkers at various stages to facilitate targeted therapeutic interventions, which would enhance patient survival rates and significantly improve prognosis. Methods We investigated the changes in gut microbiota serum metabolites during early, middle, late rats using 16S rDNA sequencing UPLC-QTOF/MS-based metabolomics. Results identified 5, 21, 14 potential microbial markers 19, 23, 31 metabolic MOD1, MOD2, MOD4 groups, respectively. Bifidobacterium was as a shared marker between MOD1 MOD2 groups; Prevotellaceae_NK3B31_group Bacteroides were groups. pathways arachidonic acid metabolism retinol found play significant role modulation 1, 2, 4 weeks. Notably, 8,9-EET 5(S)-HPETE within these emerged critical determinants influencing fibrosis. Discussion Our findings demonstrated that severity is associated with dysbiosis alterations metabolites.

Language: Английский

Citations

0
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna, Adina Boulos, Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Citations

0