Guideline-Directed Medical Therapy in Sepsis Survivors with Left Ventricular Systolic Dysfunction: An Observational Study
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(9), С. 3253 - 3253
Опубликована: Май 7, 2025
Background:
Sepsis
survivors
can
develop
left
ventricular
systolic
dysfunction
(LVSD)
and
heart
failure.
These
patients
are
often
treated
with
guideline-directed
medical
therapy
(GDMT)
known
to
be
effective
in
non-sepsis-related
This
study
sought
assess
the
use
of
GDMT
on
sepsis
LVSD.
Methods:
suspected
myocardial
injury
and/or
failure
diagnosed
LVSD
a
UK
cardiac
centre
were
retrospectively
studied.
Clinical
transthoracic
echocardiography
(TTE)
data
recorded
analysed.
Results:
Of
25
(age
56
±
11
years;
52%
males),
(44%)
had
(LVEF
<
50%).
LV
end-diastolic
internal
diameter
(LVIDd)
was
similar
between
vs.
without
(5.2
0.8
cm
4.7
cm;
p
=
0.214).
Patients
significantly
greater
end-systolic
(LVIDs)
than
those
(4.0
1.2
2.8
0.6
0.027).
Tricuspid
annular
plane
excursion
(TAPSE)
two
groups
(2.1
0.5
2.2
0.910).
LVSD,
nine
underwent
repeat
TTE
scans
after
6
months
[IQR
3–9],
most
whom
taking
GDMT.
The
majority
(8/9)
these
demonstrated
functional
recovery
(>5%
LVEF
increase;
mean
improvement
16
11%)
Reductions
seen
LVIDd
(5.3
5.0
0.7
cm)
LVIDs
(4.1
3.7
GDMT,
though
changes
did
not
reach
statistical
significance
(both
>
0.05).
Conclusions:
appears
beneficial
dysfunction.
finding
should
validated
larger
multi-centre
basis
further
affirm
value
post-sepsis
Язык: Английский
Characterization of Coronary Artery Disease in Sepsis Survivors
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1181 - 1181
Опубликована: Май 13, 2025
Background:
Sepsis
survivors
are
at
risk
of
developing
myocardial
infarction
and
heart
failure.
It
remains
unclear
whether
coronary
artery
disease
(CAD)
is
a
major
contributor
to
the
development
these
complications.
This
study
sought
characterize
burden
distribution
significant
CAD
in
sepsis
survivors.
Methods:
who
underwent
computed
tomography
angiography
(CTCA)
or
invasive
(ICA)
UK
tertiary
cardiac
center
for
suspected
ischemic
were
retrospectively
studied.
Results:
Of
30
(age
57
±
12
years;
50%
males),
21
patients
CTCA
9
ICA
median
39
days
[IQR
12-152]
from
episode.
Eight
(~27%)
had
angiographically
(n
=
6
severe
[>70%]
stenosis;
n
2
moderate
[50-70%]
stenosis).
The
CT
calcium
score
was
higher
with
compared
without
(638
[368-1015]
vs.
4
[1-72];
p
<
0.001).
8
CAD,
3
LV
systolic
dysfunction
(38%)
on
echocardiography
8/21
(p
1.00).
Long-term
adverse
complications
(all-cause
mortality
and/or
failure
hospitalization)
occurred
3/8
4/22
(18%)
0.345).
Conclusions:
A
minority
have
CAD.
presence
cannot
fully
explain
occurrence
post-sepsis
outcomes.
non-ischemic
mechanisms
underlying
cardiovascular
require
further
investigation.
Язык: Английский