Guideline-Directed Medical Therapy in Sepsis Survivors with Left Ventricular Systolic Dysfunction: An Observational Study DOI Open Access
T Oswald, Samuel Malomo, Thomas Alway

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3253 - 3253

Published: May 7, 2025

Background: Sepsis survivors can develop left ventricular systolic dysfunction (LVSD) and heart failure. These patients are often treated with guideline-directed medical therapy (GDMT) known to be effective in non-sepsis-related This study sought assess the use of GDMT on sepsis LVSD. Methods: suspected myocardial injury and/or failure diagnosed LVSD a UK cardiac centre were retrospectively studied. Clinical transthoracic echocardiography (TTE) data recorded analysed. Results: Of 25 (age 56 ± 11 years; 52% males), (44%) had (LVEF < 50%). LV end-diastolic internal diameter (LVIDd) was similar between vs. without (5.2 0.8 cm 4.7 cm; p = 0.214). Patients significantly greater end-systolic (LVIDs) than those (4.0 1.2 2.8 0.6 0.027). Tricuspid annular plane excursion (TAPSE) two groups (2.1 0.5 2.2 0.910). LVSD, nine underwent repeat TTE scans after 6 months [IQR 3–9], most whom taking GDMT. The majority (8/9) these demonstrated functional recovery (>5% LVEF increase; mean improvement 16 11%) Reductions seen LVIDd (5.3 5.0 0.7 cm) LVIDs (4.1 3.7 GDMT, though changes did not reach statistical significance (both > 0.05). Conclusions: appears beneficial dysfunction. finding should validated larger multi-centre basis further affirm value post-sepsis

Language: Английский

Guideline-Directed Medical Therapy in Sepsis Survivors with Left Ventricular Systolic Dysfunction: An Observational Study DOI Open Access
T Oswald, Samuel Malomo, Thomas Alway

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3253 - 3253

Published: May 7, 2025

Background: Sepsis survivors can develop left ventricular systolic dysfunction (LVSD) and heart failure. These patients are often treated with guideline-directed medical therapy (GDMT) known to be effective in non-sepsis-related This study sought assess the use of GDMT on sepsis LVSD. Methods: suspected myocardial injury and/or failure diagnosed LVSD a UK cardiac centre were retrospectively studied. Clinical transthoracic echocardiography (TTE) data recorded analysed. Results: Of 25 (age 56 ± 11 years; 52% males), (44%) had (LVEF < 50%). LV end-diastolic internal diameter (LVIDd) was similar between vs. without (5.2 0.8 cm 4.7 cm; p = 0.214). Patients significantly greater end-systolic (LVIDs) than those (4.0 1.2 2.8 0.6 0.027). Tricuspid annular plane excursion (TAPSE) two groups (2.1 0.5 2.2 0.910). LVSD, nine underwent repeat TTE scans after 6 months [IQR 3–9], most whom taking GDMT. The majority (8/9) these demonstrated functional recovery (>5% LVEF increase; mean improvement 16 11%) Reductions seen LVIDd (5.3 5.0 0.7 cm) LVIDs (4.1 3.7 GDMT, though changes did not reach statistical significance (both > 0.05). Conclusions: appears beneficial dysfunction. finding should validated larger multi-centre basis further affirm value post-sepsis

Language: Английский

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