Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
Fermented
foods
are
crucial
in
nutrient
supplementation,
disease
prevention,
arrest
and
management.
This
study
evaluated
the
probiotics
prebiotics
carrier
potential
of
bambara
groundnut
milk,
a
widely
consumed
drink
Africa,
for
improved
profile.
Bambara
Milk
(BGNM)
was
fermented
with
probiotic
Lactobacillus
plantarum.
After
fermentation
during
twenty-eight
days
storage,
quality
evaluated;
sensory
evaluation,
physicochemical
analysis,
antimicrobial
tests,
acid
tolerance
viability
studies
were
determined.
Animal
conducted
by
feeding.
Results
showed
that
supplementing
milk
strains.
The
prebiotic
profile,
taste,
aroma
overall
acceptability
BGNM.
animals
fed
nut
fortified
had
higher
weight
gain
than
control.
Higher
levels
lymphocytes,
monocytes,
neutrophils,
eosinophils
basophils
observed
product.
Hepatic
histopathology
results
no
toxicity
to
organs.
has
shown
BGNM
can
be
local
produce
high
through
gut,
profile
immunophysiological
benefits
damage
Nutrients,
Год журнала:
2023,
Номер
15(21), С. 4631 - 4631
Опубликована: Окт. 31, 2023
The
gut–brain
axis
(GBA)
is
a
complex
bidirectional
communication
network
connecting
the
gut
and
brain.
It
involves
neural,
immune,
endocrine
pathways
between
gastrointestinal
(GI)
tract
central
nervous
system
(CNS).
Perturbations
of
GBA
have
been
reported
in
many
neurodegenerative
disorders
(NDDs),
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
among
others,
suggesting
possible
role
pathogenesis.
microbiota
pivotal
component
GBA,
alterations
its
composition,
known
dysbiosis,
associated
with
dysfunction
neurodegeneration.
might
influence
homeostasis
CNS
by
modulating
immune
and,
more
directly,
regulating
production
molecules
metabolites
that
systems,
making
it
potential
therapeutic
target.
Preclinical
trials
manipulating
microbial
composition
through
dietary
intervention,
probiotic
prebiotic
supplementation,
fecal
transplantation
(FMT)
provided
promising
outcomes.
However,
clear
mechanism
not
well
understood,
results
are
always
consistent.
Here,
we
provide
an
overview
major
components
approaches
targeting
to
ameliorate
NDDs.
Applied Sciences,
Год журнала:
2023,
Номер
13(8), С. 4726 - 4726
Опубликована: Апрель 9, 2023
Immune
system
modulation
is
an
intriguing
part
of
scientific
research.
It
well
established
that
the
immune
plays
a
crucial
role
in
orchestrating
cellular
and
molecular
key
mediators,
thus
establishing
powerful
defense
barrier
against
infectious
pathogens.
Gut
microbiota
represent
complex
community
approximately
hundred
trillion
microorganisms
live
mammalian
gastrointestinal
(GI)
tract,
contributing
to
maintenance
gut
homeostasis
via
regulation
innate
adaptive
responses.
However,
impairment
crosstalk
between
intestinal
immunity
may
reflect
on
detrimental
health
issues.
In
this
context,
many
studies
have
indicated
probiotics
their
bioactive
compounds,
such
as
bacteriocins
short
chain
fatty
acids
(SCFAs),
display
distinct
immunomodulatory
properties
through
which
they
suppress
inflammation
enhance
restoration
microbial
diversity
pathological
states.
This
review
highlights
fundamental
features
probiotics,
bacteriocins,
SCFAs,
make
them
ideal
therapeutic
agents
for
amelioration
inflammatory
autoimmune
diseases.
also
describes
underlying
mechanisms
emphasizes
how
influence
function
cells
involved
regulating
homeostasis.
Finally,
it
discusses
future
perspectives
challenges
administration
individuals.
Foods,
Год журнала:
2023,
Номер
12(8), С. 1591 - 1591
Опубликована: Апрель 9, 2023
Prebiotics
have
become
an
important
functional
food
because
of
their
potential
for
modulating
the
gut
microbiota
and
metabolic
activities.
However,
different
prebiotics
can
stimulate
growth
probiotics.
The
optimization
was
focused
on
in
this
study
order
to
representative
probiotics'
(Lacticaseibacillus
rhamnosus
(previously
Lactobacillus
rhamnosus)
Bifidobacterium
animalis
subsp.
lactis)
function.
culture
medium
supplemented
with
three
prebiotics,
including
inulin
(INU),
fructooligosaccharides
(FOS),
galactooligosaccharides
(GOS).
All
clearly
probiotic
strains
both
monoculture
co-culture.
specific
rates
L.
B.
lactis
were
shown
GOS
(0.019
h-1)
FOS
(0.023
h-1),
respectively.
prebiotic
index
(PI)
scores
INU
(1.03),
(0.86),
(0.84)
co-culture
at
48
h
significantly
higher
than
control
(glucose).
mixture
achieve
high
quality
optimized
using
Box-Behnken
design.
optimum
ratios
INU,
FOS,
1.33,
2.00,
2.67%
w/v,
respectively,
highest
stimulated
occurring
PI
score
(1.03)
total
short
chain
fatty
acid
concentration
(85.55
µmol/mL).
suitable
ratio
mixed
will
function
as
a
ingredient
foods
or
colonic
foods.
Journal of Food Science,
Год журнала:
2025,
Номер
90(2)
Опубликована: Фев. 1, 2025
Abstract
To
prepare
functional
yacon
juice,
this
study
investigates
the
optimal
fermentation
duration,
shelf‐life,
chemical
composition,
and
flavor
volatiles
of
juice
fermented
by
Lactiplantibacillus
plantarum
QS7T
capable
utilizing
fructo‐oligosaccharides
(FOS),
along
with
its
effects
on
gut
microbiota.
The
period
was
determined
as
30
h,
resulting
in
essential
parameters:
3.46
g
L
−1
for
total
acids
a
viable
lactic
acid
bacteria
(LAB)
count
2.3
×
10
8
CFU
mL
.
predicted
shelf
life
when
stored
at
4°C
is
28
days.
Throughout
storage,
maintained
significant
FOS
LAB
(8.0
7
).
Total
short‐chain
fatty
significantly
increased
post‐fermentation
reaching
177.86
µg
content
types
volatile
components
after
L.
increased,
thus
altering
improving
juice's
appeal.
Functional
also
induced
alterations
microbiota
structure
abundance
mice,
including
increasing
beneficial
microbes
such
Firmicutes,
Actinobacteriota,
Faecalibaculum,
Dubosiella,
Bifidobacterium,
Akkermansia
These
results
indicate
potential
food
modulation
anti‐inflammatory
benefits.
Nutrients,
Год журнала:
2021,
Номер
13(8), С. 2887 - 2887
Опубликована: Авг. 22, 2021
Sargassum
fusiforme
alginate
(SF-Alg)
possess
many
pharmacological
activities,
including
hypoglycemic
and
hypolipidemic.
However,
the
mechanisms
of
SF-Alg
remain
unclear
due
to
its
low
bioavailability.
In
this
study,
we
evaluated
therapeutic
effect
on
high-fat
diet
(HFD)/streptozotocin
(STZ)-induced
type
2
diabetes
(T2D)
mice.
intervention
was
found
significantly
reduce
fasting
blood
glucose
(FBG),
triglycerides
(TG),
total
cholesterol
(TC),
while
increasing
high-density
lipoprotein
(HDL-c)
improving
tolerance.
addition,
administrating
diabetic
mice
moderately
attenuated
pathological
changes
in
adipose,
hepatic,
heart
tissues
as
well
skeletal
muscle,
diminished
oxidative
stress.
To
probe
underlying
mechanisms,
further
analyzed
gut
microbiota
using
16S
rRNA
amplicon
sequencing,
metabolites
by
non-targeted
metabolomics.
Here,
increased
some
benign
bacteria
(Lactobacillus,
Bacteroides,
Akkermansia
Alloprevotella,
Weissella
Enterorhabdus),
decreased
harmful
(Turicibacter
Helicobacter).
Meanwhile,
dramatically
branched-chain
amino
acids
(BCAAs)
aromatic
(AAAs)
colon
T2D
mice,
suggesting
a
positive
benefit
an
adjvant
agent
for
T2D.
American Journal of Obstetrics and Gynecology,
Год журнала:
2022,
Номер
227(3), С. 392 - 400
Опубликована: Апрель 19, 2022
A
healthy
diet
before
and
during
pregnancy
is
beneficial
in
acquiring
essential
B
vitamins
involved
1-carbon
metabolism,
maintaining
a
gut
microbiota.
Each
play
important
roles
fetal
development,
immune-system
remodeling,
pregnancy-nutrient
acquisition.
Evidence
shows
that
there
reciprocal
interaction
between
the
one-carbon
metabolism
microbiota
given
dietary
intake
of
has
been
shown
to
influence
composition
microbiota,
certain
bacteria
also
synthesize
vitamins.
This
contributes
individual's
overall
availability
and,
therefore,
should
be
maintained
state
pregnancy.
There
an
emerging
consensus
obese
pregnant
women
often
have
derangements
dysbiosis
owing
high
nutritiously
poor
foods
chronic
systemic
inflammatory
state.
For
example,
low
folate
vitamin
B12
coincide
with
decreased
presence
vitamin-producing
increased
inflammatory-associated
from
approximately
mid-pregnancy.
These
alterations
are
risk
factors
for
adverse
outcomes,
impaired
disruption
growth
formation,
which
may
lead
potential
long-term
offspring
metabolic
neurologic
disorders.
Therefore,
preconceptional
benefit
lifestyle
counseling
improve
their
nutrient
intake,
monitoring
levels
microbiome
by
blood
tests
stool
samples.
In
addition,
evidence
some
probiotic
biosynthetic
capacity
could
used
treat
dysbiosis.
Thus,
use
as
intervention
strategy
holds
further
investigated.
Currently,
many
knowledge
gaps
concerning
relationship
future
research
focus
on
strategies
counteract
deficiencies
women,
commencing
prebiotic
supplements.
Metabolites,
Год журнала:
2022,
Номер
12(12), С. 1165 - 1165
Опубликована: Ноя. 23, 2022
In
recent
years,
the
importance
of
gut
microbiome
in
human
health
and
disease
has
increased.
Growing
evidence
suggests
that
dysbiosis
might
be
a
crucial
risk
factor
for
coronary
artery
(CAD).
Therefore,
we
conducted
systematic
review
meta-analysis
to
determine
whether
or
not
CAD
is
associated
with
specific
changes
microbiome.
The
V3-V4
regions
16S
rDNA
from
fecal
samples
were
analyzed
compare
composition
between
patients
controls.
Our
search
yielded
1181
articles,
which
21
met
inclusion
criteria
7
meta-analysis.
alpha-diversity,
including
observed
OTUs,
Shannon
Simpson
indices,
was
significantly
decreased
CAD,
indicating
reduced
richness
most
consistent
results
pointed
out
abundance
