Effect of apigenin on seizure susceptibility, parvalbumin immunoreactivity, and GABAA receptor expression in the hippocampal neurons in mice

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177548 - 177548

Опубликована: Март 1, 2025

Язык: Английский

---

Protective effects of betanin, a novel acetylcholinesterase inhibitor, against H2O2-induced apoptosis in PC12 cells

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Сен. 16, 2024

Язык: Английский

---

Magnoflorine from Berberis vulgaris Roots—Impact on Hippocampal Neurons in Mice after Short-Term Exposure

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7166 - 7166

Опубликована: Апрель 12, 2023

In search of novel potential drug candidates that could be used as treatments or prophylactics for memory impairment, an aporphine alkaloid magnoflorine (MAG) isolated from the root Berberis vulgaris was proven to exhibit beneficial anti-amnestic properties. Its effects on immunoreactivity parvalbumin in mouse hippocampus were assessed together with a study its safety and concentration brain plasma. For this purpose, four experimental groups created: MAG10 group-treated 10 mg MAG/kg b.w. i.p., MAG20 20 MAG50 50 control group-injected saline i.p. at volume corresponding their weight. Our results indicated hippocampal fields CA1-CA3 characterized by elevated number parvalbumin-immunoreactive neurons (PV-IR) nerve fibers mice doses mg/kg (i.p.). No significant changes levels IL-1β, IL-6 TNF-α observed above two doses; however, administration caused statistically elevation IL-6, IL-1beta plasma insignificant raise TNF-alpha value. The HPLC-MS analysis showed alkaloid's content structures group treated did not increase proportionally administered dose. obtained show MAG is able influence PV-IR might act neuroprotective compound.

Язык: Английский

---

Specific vegetable types are associated with lower long-term risk for late-life dementia: the Perth Longitudinal Study of Aging Women

Food & Function, Год журнала: 2024, Номер 15(21), С. 10885 - 10895

Опубликована: Янв. 1, 2024

This study found an association between total vegetable intake as well specific types of vegetables including yellow/orange/red, green leafy, and allium with lower long-term risk for late-life dementia in older women.

Язык: Английский

---