Journal of Functional Foods,
Год журнала:
2023,
Номер
108, С. 105776 - 105776
Опубликована: Сен. 1, 2023
Pueraria
lobata
roots
and
Glycine
max
(L.)
Merrill
are
rich
in
isoflavones,
which
phytoestrogens
known
to
alleviate
menopausal
some
disease
symptoms.
However,
the
high
molecular
weight
poor
bioavailability
of
owing
glucose
moieties
attached
these
glycosides,
limit
their
practical
use.
Fermentation
with
lactic
acid
bacteria
has
been
reported
convert
glycosides
into
aglycone
forms.
In
this
study,
we
investigated
health-promoting
effects
fermented
P.
root
extract
(FPE)
G.
(FGE)
using
ovariectomized
mice.
The
was
bacteria.
Lactiplantibacillus
plantarum
strains
that
aglycones
were
selected,
vitro
vivo
experiments
conducted
confirm
various
functionalities
resulting
from
fermentation.
FPE
FGE
exhibited
estrogen-like
activities.
particular,
fermentation
increased
expression
estrogen
receptor
beta
(ERβ),
as
a
result
extracts
should
probably
not
be
associated
increasing
incidence
female
cancers—a
common
side
effect
hormone
replacement
therapy.
addition,
oral
administration
FPE,
FGE,
or
mixture
two
(FPE-FGE)
mice
improved
depressive
symptoms
by
upregulating
hippocampal
brain-derived
neurotrophic
factor
(BDNF).
ERβ
highest
FPE-FGE
group.
These
results
indicate
can
used
raw
material
for
development
dietary
supplements
women
because
it
increases
alleviates
depressive-like
behavior
through
regulation
BDNF
neurotransmitters.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(3)
Опубликована: Март 1, 2025
ABSTRACT
Isoflavones
are
currently
being
investigated
by
researchers
in
order
to
demonstrate
their
ability
prevent
the
proliferation
of
cancer
cells.
The
current
review
aimed
potential
isoflavones
eliminate
cancerous
cells
stomach,
liver,
lung,
breast,
and
prostate,
as
anticancer
properties
due
block
signaling
pathways
extracellular
signal‐controlled
kinase
(MAPK/ERK)
proteasome
(PI3K/AKT/mTOR).
can
inhibit
cell
division
various
androgen
receptor
(AR),
a
protein
that
is
required
for
growth
dissemination
prostate
cancer.
It
initiates
caspase
cascade
obstructs
production
new
proteins
lung
These
colon
entering
G2/M
cycle
phase
inducing
apoptosis.
also
known
cyclin‐dependent
2
cyclin
B1,
two
related
an
enhanced
risk
suppress
breakdown
B1
CDK2
stop
development
Preclinical
evidence
consistently
supports
efficacy
suppressing
tumor
growth;
however,
human
clinical
trials
show
variability
differences
bioavailability,
metabolism,
dosage.
Despite
promise
alternative
or
adjunctive
therapies,
limitations
such
low
solubility,
interindividual
metabolic
variations,
inconsistent
outcomes
necessitate
further
large‐scale,
controlled
trials.
Future
research
should
focus
on
improving
bioavailability
exploring
synergistic
effects
with
conventional
therapies.
Foods,
Год журнала:
2023,
Номер
12(12), С. 2334 - 2334
Опубликована: Июнь 10, 2023
Equol
is
the
most
potent
soy
isoflavone
metabolite
and
produced
by
specific
intestinal
microorganisms
of
mammals.
It
has
promising
application
possibilities
for
preventing
chronic
diseases
such
as
cardiovascular
disease,
breast
cancer,
prostate
cancer
due
to
its
high
antioxidant
activity
hormone-like
activity.
Thus,
it
great
significance
systematically
study
efficient
preparation
method
equol
functional
This
paper
elaborates
on
metabolic
mechanism
in
humans;
focuses
biological
characteristics,
synthesis
methods,
currently
isolated
equol-producing
bacteria;
looks
forward
future
development
direction,
aiming
provide
guidance
promotion
field
food
health
products.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101288 - 101288
Опубликована: Янв. 1, 2024
Daidzein
is
an
abundant
polyphenol
present
in
soy
and
other
legumes.
It
accumulates
mostly
seed
pod
during
the
plant
development
response
to
biotic
abiotic
stress.
Due
high
consumption
of
derivative
food,
daidzein
one
most
polyphenols
human
cattle
diets.
Similar
phytochemicals,
not
absorbed
or
metabolized
by
cells,
but
transformed
enzymatic
cascades
gut
microbiome.
The
product
"fermentation"
equol
related
molecules.
Equol
[7-hydroxy-3-(4'-hydroxyphenyl)-chroman]
considered
active
metabolite
all
soybean
isoflavones,
presenting
a
level
antioxidant
estrogenic
activity.
This
bioactive
molecule
presents
estrogen-like
activity
specifically
binding
5α-dihydrotestosterone
inhibiting
its
androgen
receptor.
Biotransformation
into
requires
enzymes
that
are
widespread
along
microbiome
taxa
restricted
relatively
small
number
from
family
Eggerthellaceae
(phylum
Actinomycetota,
formerly
Actinobacteria),
strict
anaerobes
inhabit
colon
humans
anoxic
areas
intestinal
tract
mammals.
isolation
characterization
equol-producing
bacteria
resulted
identification
bacterial
species
that,
due
their
metabolic
capacity,
were
named
Adlercreutzia
equolifaciens,
Slackia
isoflavoniconvertens,
among
others.
Combining
genomic
biochemical
analysis,
puzzle
diadzein
biotransformation
was
decoded.
includes
initial
step
catalyzed
β-glucosidases,
commonly
found
deglycosylate
natural
form
plant,
followed
action
reductase,
dihydrodaidzein
tetrahydrodaidzein
racemase.
Undoubtedly,
improving
production
products
enhancing
notorious
biotechnological
biomedical
interest.
In
addition,
chemistry
biosynthetic
interest
green
field.
However,
extreme
oxygen
sensitivity
microbes
participate
these
pathways
still
impose
challenge
for
translating
knowledge
obtained
with
recombinant
model
organisms
food
industry.
this
manuscript
we
review
process
biosynthesis
effort
synthetic
biology
industrial
setups.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 24, 2025
The
therapeutic
potential
of
(S)-Equol
across
various
health
domains,
including
mental
and
oncology
has
been
identified
studied
enormously.
However,
the
pharmacokinetic
study
on
enantiopure
in
male
female
rats
under
graded
doses
remain
untouched,
concentrates
same.
Male
CD(SD)IGS
were
grouped
into
8
groups
some
administered
with
20,
60
160
mg/kg
body
weight,
orally
other
intravenous
bolus
injection
at
10
weight
(S)-Equol.
plasma
concentrations
estimated
by
LC-MS/MS
parameters
determined
from
concentration
time
data
non-compartmental
PK
analysis.
observed
Cmax
was
66.78,
659.38,
2542.02
ng/mL
males
392.08,
1661.97,
4879.36
rats,
similarly,
AUCLast
118.96,
1130.32,
4876.00
h*ng/mL
2164.01,
4883.09,
14067.94
dose
respectively.
administration
showed
8563.25,
8642.91
3742.98,
3551.90
oral
bioavailability
found
to
be
1.59,
5.03,
8.14%
30.46,
22.91,
66.01%
These
suggesting
that
gender
related
differences
exposure,
increased
exposure
mg/mL
comparable
exposures
rats.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1068 - 1068
Опубликована: Фев. 26, 2025
The
global
prevalence
of
type
2
diabetes
mellitus
(T2DM)
necessitates
the
exploration
novel
therapeutic
approaches
to
mitigate
its
complex
molecular
pathogenesis.
This
review
investigates
potential
role
genistein,
a
prominent
isoflavone
derived
from
soybeans,
in
management
T2DM.
Recognized
for
selective
estrogen
receptor
modulator
(SERM)
activity,
genistein
exerts
multifaceted
influence
on
key
intracellular
signaling
pathways,
which
are
crucial
regulating
cell
proliferation,
apoptosis,
and
insulin
signaling.
Genistein's
anti-inflammatory,
anti-oxidant,
metabolic
regulatory
properties
position
it
as
promising
candidate
T2DM
intervention.
synthesizes
current
research
spanning
preclinical
studies
clinical
trials,
emphasizing
genistein's
impact
sensitivity,
glucose
metabolism,
inflammatory
markers.
Additionally,
this
addresses
bioavailability,
safety,
gut
microbiota
composition.
By
consolidating
these
findings,
aims
provide
comprehensive
understanding
management,
offering
valuable
insights
future
practice.
Fermentation,
Год журнала:
2025,
Номер
11(4), С. 212 - 212
Опубликована: Апрель 12, 2025
Processing
wastewater
of
yuba
(PWY),
a
by-product
production,
contains
valuable
bioactive
compounds
such
as
soy
isoflavones.
However,
its
utilization
remains
limited.
This
study
investigated
the
effects
Lactiplantibacillus
plantarum
fermentation
on
bioactivity
PWY,
focusing
antioxidant
properties
and
gut
microbiota
modulation.
The
resulted
in
significantly
increased
amount
free
flavonoids
from
63.62
μg/mL
to
145.91
μg/mL,
transformed
glycosylated
isoflavones
into
their
more
bioavailable
aglycone
forms.
FPWY
exhibited
stronger
activity
than
non-fermented
PWY
(NFPWY)
indicated
by
DPPH,
ABTS,
FRAP
assays.
Furthermore,
promoted
growth
beneficial
bacteria,
including
Bifidobacterium,
Akkermansia,
Ruminococcus,
butyrate
while
inhibiting
Escherichia
coli.
also
enhanced
production
short-chain
fatty
acids
(SCFAs),
with
propionic
acid
increasing
5.01
9.30
mmol/L
butyric
0.11
2.54
mmol/L.
These
findings
suggest
that
has
effect
relation
health
oxidative
stress.
Fermentation,
Год журнала:
2023,
Номер
9(10), С. 918 - 918
Опубликована: Окт. 19, 2023
Fermented
coffee
beans
are
believed
to
have
significantly
different
compositions
of
phenolic
and
volatile
compounds
physicochemical
properties
compared
unfermented
beans.
This
study
evaluated
the
effects
fermentation
on
at
a
commercially
roasted
level
by
characterizing
their
semi-quantifying
using
liquid
chromatography–electrospray
ionization
quadrupole
time-of-flight
mass
spectrometry
(LC-ESI-QTOF-MS/MS)
headspace/gas
chromatography–mass
(HS-SPME-GC-MS).
Coffee
from
two
varieties
Coffea
arabica,
Geisha
(G)
Bourbon
(B),
both
fermented
had
higher
contents
total
(G:
33.52
mg/g;
B:
29.95
mg/g),
flavonoid
0.42
0.35
tannins
3.49
3.18
antioxidant
potential
in
all
assays.
In
total,
131
were
tentatively
characterized
via
LC-ESI-QTOF-MS/MS,
where
73
65
Bourbon,
respectively.
Regarding
GC-MS,
levels
phenols,
pyrazines,
furan,
furanic
compounds.
These
findings
substantiated
that
exhibit
elevated
greater
activity,
which
could
contribute
relatively
nutritional
values
organoleptic
properties.
