Microbiological Research, Год журнала: 2024, Номер unknown, С. 128037 - 128037
Опубликована: Дек. 1, 2024
Язык: Английский
Food Hydrocolloids, Год журнала: 2024, Номер 156, С. 110314 - 110314
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
14
Gut Pathogens, Год журнала: 2024, Номер 16(1)
Опубликована: Июль 7, 2024
Abstract An increasing number of studies have shown that the consumption soybeans and products is beneficial to human health, biological activity soy may be attributed presence Soy Isoflavones (SI) in soybeans. In intestinal tracts humans animals, certain specific bacteria can metabolize isoflavones into equol. Equol has a similar chemical structure endogenous estradiol body, which bind with estrogen receptors exert weak effects. Therefore, equol plays an important role occurrence development variety hormone-dependent malignancies such as breast cancer prostate cancer. Despite numerous health benefits for humans, only 30-50% population equol, individual variation gut microbiota being main reason. This article provides overview relevant involved synthesis its anti-tumor effects various types It also summarizes molecular mechanisms underlying properties, aiming provide more reliable theoretical basis rational utilization field treatment.
Язык: Английский
Процитировано
8
Journal of the American Heart Association, Год журнала: 2024, Номер 13(13)
Опубликована: Июнь 27, 2024
The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers including daidzein, glycitein, genistein, equol (a gut microbial metabolite daidzein), equol-predicting species with risk markers.
Язык: Английский
Процитировано
6
Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Март 12, 2024
Abstract Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study to demonstrate the effect multistrain probiotics (Sensi-Biome) on diarrhea from perspective microbiome-neuron axis. Sensi-Biome ( Lactiplantibacillus plantarum , Bifidobacterium animalis subsp. lactis Lactobacillus acidophilus Streptococcus thermophilus bifidum and Lactococcus ) was administered 4% acetic acid–induced rat model at concentrations 1 × 10 8 (G1), 9 (G2), CFU/0.5 mL (G3). Diarrhea-related parameters, inflammation-related cytokines, stool microbiota analysis by 16S rRNA were evaluated. A targeted untargeted metabolomics approach used analyze cecum samples using liquid chromatography orbitrap mass spectrometry. moisture content p < 0.001), intestinal movement rate 0.05), pH 0.05) significantly recovered G3. Serotonin levels decreased groups. inflammatory serotonin, tryptophan hydroxylase expression improved At phylum level, showed highest relative abundance Firmicutes . Short-chain fatty acids including butyrate, iso-butyrate, propionate, iso-valeric acid modified Equol oleamide In conclusion, effectively controls modulating metabolites serotonin pathway.
Язык: Английский
Процитировано
4
Metabolites, Год журнала: 2025, Номер 15(3), С. 198 - 198
Опубликована: Март 13, 2025
Cardiovascular diseases are a leading cause of death worldwide, and the process cardiac remodeling lies at core most these diseases. Sustained almost unavoidably ends in progressive muscle dysfunction, heart failure, ultimately death. Therefore, order to attenuate reduce mortality, different therapies have been used, but it is important identify adjuvant factors that can help modulate this process. One inclusion affordable foods diet with potential cardioprotective properties. Orange juice intake has associated several beneficial metabolic changes, which may influence induced by cardiovascular Current opinion highlights how metabolites pathways modulated orange consumption could potentially remodeling. It was observed significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, gut microbiota diversity, improving insulin resistance, dyslipidemia, syndrome. Specifically, modulation phosphatidylethanolamine (PE) metabolism activation PPARα PPARγ receptors, improved mitochondrial function, oxidative stress, showed protective effects on heart. Furthermore, positively impacted diversity led an increase bacterial populations, correlated These findings suggest act as modulator, therapeutic implications for
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106715 - 106715
Опубликована: Март 16, 2025
Язык: Английский
Процитировано
0
Journal of Obstetrics and Gynaecology Research, Год журнала: 2025, Номер 51(3)
Опубликована: Март 1, 2025
We aimed to investigate the relationship between lower urinary tract symptoms in females and their equol production capacity. In this cross-sectional study, capacity of Japanese women (aged 20-75 years), with (group L, n = 95) without C, 122) symptoms, was examined. Equol determined by measuring concentration immunochromatography. defined as a 1.0 μM or more. The presence using three questionnaires that evaluated symptoms. proportions groups L C were 28.4% 52.5%, respectively (p 0.0004). Multivariate analysis (logistic regression analysis) showed inability produce significant risk factor for (odds ratio, 2.21; p 0.0144). This study revealed may be associated Further research, including interventional studies, is required verification. Additionally, because include variety association each symptom needs investigated.
Язык: Английский
Процитировано
0
Food & Function, Год журнала: 2024, Номер 15(18), С. 9471 - 9487
Опубликована: Янв. 1, 2024
Equol is a highly active product of soy isoflavones produced by specific bacteria in the human or animal colon. However, equol production influenced differences gut flora carried body. Our previous research has shown that synbiotic preparation comprising probiotic Lactobacillus rhamnosus ATCC 7469 and prebiotic lactulose can enhance modulating intestinal flora. Nevertheless, harsh environment gastrointestinal tract limits this capability diminishing number probiotics reaching Microencapsulation an effective strategy to their viability. In study, gel microspheres (SA-S-CS) were prepared using extrusion method, with sodium alginate (SA) chitosan (CS) serving as encapsulating materials. Scanning electron microscopy (SEM) was employed observe surface morphology internal distribution within microcapsules. The structural characteristics microcapsules investigated Fourier-transform infrared spectroscopy (FTIR) X-ray diffraction (XRD). Furthermore, thermal stability, storage viability post-simulated fluid treatment, colon release rate examined. Finally, impact microencapsulation on promoting assessed. results indicated exhibited spherical structure evenly distributed inner surface. Studies stability showed viable cells microcapsule group significantly increased compared free group. Gastrointestinal tolerance studies revealed after vitro simulated digestion, amount 7 log10 CFU g-1, demonstrating good tolerance. Moreover, incubation colonic for 150 min, reached 93.13%. This suggests chitosan-coated shield from environment, offering novel model production.
Язык: Английский
Процитировано
3
Nutrients, Год журнала: 2024, Номер 16(5), С. 655 - 655
Опубликована: Фев. 26, 2024
The causes of vasomotor symptoms, including hot flashes, are not fully understood, may be related to molecular factors, and have a polygenic architecture. Nutrients bioactive molecules supplied the body with food metabolized using various enzymatic pathways. They can induce cell signaling pathways and, consequently, activate effector proteins that modulate processes flashes in menopausal women. In this review, we analyzed literature data from last 5 years, especially regarding genome-wide association study (GWAS) analysis, selected factors potentially These kisspeptin-GnRH pathway, adipocyte-derived hormones, aryl hydrocarbon receptor signaling, catechol estrogens estrogen sulfotransferase, inflammatory oxidative stress biomarkers, glucose availability. Then, single compounds or groups ingredients were that, according experimental data, influence course discussed thus considered as potential natural therapeutic agents effectively reduce troublesome symptoms menopause
Язык: Английский
Процитировано
2
Journal of Nutrition, Год журнала: 2024, Номер 154(9), С. 2843 - 2851
Опубликована: Июль 20, 2024
Язык: Английский
Процитировано
2