Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management

Antioxidants, Год журнала: 2024, Номер 13(4), С. 429 - 429

Опубликована: Март 30, 2024

Polyphenols, as secondary metabolites ubiquitous in plant sources, have emerged pivotal bioactive compounds with far-reaching implications for human health. Plant polyphenols exhibit direct or indirect associations biomolecules capable of modulating diverse physiological pathways. Due to their inherent abundance and structural diversity, garnered substantial attention from both the scientific clinical communities. The review begins by providing an in-depth analysis chemical intricacies polyphenols, shedding light on diversity such biological activities. Subsequently, exploration dietary origins elucidates natural plant-based sources that contribute global availability. discussion extends bioavailability metabolism within body, unraveling complex journey ingestion systemic effects. A central focus is dedicated unravelling antioxidant effects highlighting role combating oxidative stress associated health conditions. comprehensive encompasses impact concerns hypertension, allergies, aging, chronic diseases like heart stroke diabetes. Insights into beneficial further underscore potential preventive therapeutic agents. This article critically examines multifaceted aspects encompassing chemistry, origins, bioavailability/metabolism dynamics, profound synthesis information presented herein aims provide a valuable resource researchers, clinicians, enthusiasts, fostering deeper understanding intricate relationship between

Язык: Английский

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The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

FEBS Journal, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Huntington's disease (HD) is a currently incurable neurogenerative disorder and typically characterized by progressive movement (including chorea), cognitive deficits (culminating in dementia), psychiatric abnormalities (the most common of which depression), peripheral symptoms gastrointestinal dysfunction). There are no approved disease‐modifying therapies available for HD, with death usually occurring approximately 10–25 years after onset, but some hold promising potential. HD subjects often burdened chronic diarrhea, constipation, esophageal gastric inflammation, susceptibility to diabetes. Our understanding the microbiota–gut–brain axis its infancy growing evidence from preclinical clinical studies suggests role gut microbial population imbalance (gut dysbiosis) pathophysiology. The brain can communicate through enteric nervous system, immune vagus nerve, microbiota‐derived‐metabolites including short‐chain fatty acids, bile branched‐chain amino acids. This review summarizes supporting demonstrating alterations bacterial fungal composition that may be associated HD. We focus on mechanisms dysbiosis compromise health, thus triggering neuroinflammatory responses, further highlight outcomes attempts modulate microbiota as therapeutic strategies Ultimately, we discuss dearth data need more longitudinal translational this nascent field. suggest future directions improve our association between microbes pathogenesis other ‘brain body disorders’.

Язык: Английский

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Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols

Food Hydrocolloids, Год журнала: 2023, Номер 146, С. 109221 - 109221

Опубликована: Авг. 28, 2023

In recent years, the consumption of functional foods containing health-beneficial ingredients has become increasingly popular. Polyphenols are among most important and bioactive molecules found in a variety fresh produce food products. However, limited solubility polyphenols water can significantly affect their bioavailability, thereby reducing potential health benefits. To overcome this limitation, various approaches have been explored, including molecular enhancers, nanoparticles, encapsulation systems, conjugation methods. review, we focus on advances methods for enhancing bioavailability polyphenols. We provide concise overview types determination and, subsequently, discuss concept methods, different synthesizing confirmation procedures, effects polysaccharides Overall, review provides comprehensive update that be used to improve highlights these enhance benefits polyphenol-rich foods.

Язык: Английский

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Polyphenols and Intestinal Microorganisms: A Review of Their Interactions and Effects on Human Health

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105220 - 105220

Опубликована: Сен. 1, 2024

Язык: Английский

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Phenolic compounds in dietary target the regulation of gut microbiota: Role in health and disease

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105107 - 105107

Опубликована: Сен. 1, 2024

Язык: Английский

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Immune Restoration Mechanism Analysis of Akkermansia PROBIO in Mice Treated with Cyclophosphamide through Re-balancing Microbiota Composition

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106450 - 106450

Опубликована: Март 1, 2025

Язык: Английский

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Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology

Cell chemical biology, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Язык: Английский

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Plant-based probiotic foods: current state and future trends

Food Science and Biotechnology, Год журнала: 2024, Номер 33(15), С. 3401 - 3422

Опубликована: Авг. 28, 2024

Язык: Английский

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Mediterranean diet and chronotype: Data from Italian adults and systematic review of observational studies

Experimental Gerontology, Год журнала: 2023, Номер 181, С. 112284 - 112284

Опубликована: Сен. 8, 2023

Scientific evidence suggests a relation between dietary factors and sleep. Several studies show that higher adherence to the Mediterranean diet is associated with better sleep quality, but chronotype has been only recently explored. The aim of this study was understand adherence. For purpose, an analysis 1936 adults (age 18–90 y) living in Italy performed investigate association (assessed short form morningness-eveningness questionnaire) through 110-item food frequency questionnaire Medi-Lite literature-based score). A multivariate logistic regression conducted calculate odds ratios (OR) 95 % confidence intervals (CIs) describing chronotypes high (>14 points). Moreover, systematic review other observational published so far performed. Individuals reporting having intermediate (n = 614) evening 173) were less likely have compared morning (OR 0.28, CI: 0.18, 0.42 OR 0.08, 0.03, 0.27, respectively). When subgroups age, results similar mid-age (>50 participants (for chronotypes, 0.21, 0.10, 0.43 0.92, 0.01, 0.69, respectively) while lost significance older (>60 0.09, 0.82 0.22, 0.02, 1.92, Out 10 (date range publication 2020–2022) included review, there general consistence findings showing among although few reported null results. In conclusion, current could be lower diet, modified by when considering individuals.

Язык: Английский

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Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson’s Disease

Molecules, Год журнала: 2023, Номер 28(22), С. 7588 - 7588

Опубликована: Ноя. 14, 2023

Neurological ailments, including stroke, Alzheimer's disease (AD), epilepsy, Parkinson's (PD), and other related diseases, have affected around 1 billion people globally to date. PD stands second among the common neurodegenerative diseases caused as a result of dopaminergic neuron loss in midbrain's substantia nigra regions. It affects cognitive motor activities, resulting tremors during rest, slow movement, muscle stiffness. There are various traditional approaches for management PD, but they provide only symptomatic relief. Thus, survey finding new biomolecules or substances exhibiting therapeutic potential patients with is main focus present-day research. Medicinal plants, herbal formulations, natural bioactive molecules been gaining much more attention recent years synthetic orchestrate number undesired effects. Several vitro, vivo, silico studies past demonstrated medicinal plant-based bioactives. Among bioactives, polyphenols, terpenes, alkaloids particular interest due their potent anti-inflammatory, antioxidant, brain-health-promoting properties. Further, there no concise, elaborated articles comprising updated mechanism-of-action-based reviews published literature on potent, recently investigated (2019-2023) plant based-bioactive molecules, alkaloids, method PD. Therefore, we designed current review an illustration efficacious role bioactives (polyphenols, alkaloids) that can become therapeutics against greater specificity, target approachability, bioavailability, safety host. This information be further utilized future develop several value-added formulations nutraceutical products achieve desired efficacy

Язык: Английский

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