Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Ноя. 19, 2024
Dietary
modifications
to
overcome
infertility
have
attracted
attention;
however,
scientifically
substantiated
information
on
specific
dietary
components
affecting
fertility
and
their
mechanisms
is
limited.
Herein,
we
investigated
diet-induced,
reversible
in
female
mice
lacking
the
heterodimer
of
ATP-binding
cassette
transporters
G5
G8
(ABCG5/G8),
which
functions
as
a
lipid
exporter
intestine.
We
found
that
phytosterols,
especially
β-sitosterol
brassicasterol,
are
substrates
ABCG5/G8,
potent
but
reproductive
toxicities
mice.
Mechanistically,
these
phytosterols
inhibited
ovarian
folliculogenesis
reduced
egg
quality
by
enhancing
polycomb
repressive
complex
2-mediated
histone
H3
trimethylation
at
lysine
27
ovary.
Clinical
analyses
showed
serum
phytosterol
levels
were
significantly
negatively
correlated
with
blastocyst
development
rate
fertilized
eggs
women
undergoing
vitro
fertilization,
suggesting
affect
both
humans
Thus,
avoiding
excessive
intake
certain
would
be
beneficial
for
health.
In
mouse
ovary,
shown
inhibit
reduce
PRC2-mediated
trimethylation.
Molecules,
Год журнала:
2025,
Номер
30(1), С. 160 - 160
Опубликована: Янв. 3, 2025
Sacha
inchi
(Plukenetia
volubilis
L.),
an
oilseed
native
to
the
Peruvian
rainforest,
has
garnered
attention
for
its
valuable
components
and
potential
applications
in
food,
pharmaceutical,
nutraceutical
industries.
oil
is
rich
fatty
acids,
particularly
omega-3,
omega-6,
omega-9,
along
with
antioxidants
such
as
tocopherols,
which
collectively
contribute
cardiovascular
health,
antioxidant,
anti-inflammatory,
antiproliferative,
neuroprotective
effects.
The
susceptibility
of
oxidation
poses
significant
challenges
both
storage
processing,
making
it
essential
employ
microencapsulation
technologies
preserve
integrity
extend
shelf
life.
This
paper
aims
provide
a
review
therapeutic
potential,
extraction
methods,
strategies
enhancing
oil’s
stability
bioavailability.
Optimizing
processes
encapsulation
would
enhance
bioavailability,
enabling
be
more
effectively
utilized
functional
foods
across
pharmaceutical
fields.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 17, 2025
Excessive
gestational
weight
gain
may
be
associated
with
unfavorable
pregnancy
outcomes.
We
explored
the
impact
of
excessive
on
components
HDL
metabolism
in
maternal
plasma:
sterol
composition
particles,
distribution
subclasses
and
SCARB1,
ABCA1
ABCG1
genes
expressions
their
associations
newborns'
characteristics.
The
study
included
124
pregnant
women,
58
recommended
66
gain.
Concentrations
cholesterol
synthesis
marker,
desmosterol,
within
increased
during
both
groups
participants.
In
women
gain,
levels
absorption
campesterol,
were
significantly
lower
3rd
trimester
compared
to
1st
2nd
trimesters.
Relative
proportions
large
2b
Women
high
pre-pregnancy
BMI
had
lowest
β-sitosterol
highest
relative
3a
3b
trimester.
Large
particles
positive
correlation,
while
smaller
3
SCARB1
gene
negative
correlation
APGAR
scores.
conclusion,
could
contribute
altered
HDL,
subsequently
poorer
neonatal
Plants,
Год журнала:
2025,
Номер
14(6), С. 897 - 897
Опубликована: Март 13, 2025
The
rising
prevalence
of
infectious
diseases
and
immune-related
disorders
underscores
the
need
for
effective
accessible
therapeutic
solutions.
Herbal
immunostimulants
derived
from
medicinal
plants
offer
promising
alternatives,
enhancing
immune
responses
with
lower
toxicity
fewer
side
effects
than
synthetic
drugs.
This
review
explores
immunostimulatory
potential
Morinda
citrifolia,
Echinacea
purpurea,
Phyllanthus
niruri,
focusing
on
their
bioactive
compounds,
mechanisms
action,
relevance.
These
modulate
innate
adaptive
by
activating
macrophages,
dendritic
cells,
lymphocytes
while
regulating
cytokine
production
to
maintain
homeostasis.
Their
immunomodulatory
are
linked
key
signaling
pathways,
including
NF-κB,
MAPK,
JAK/STAT.
In
vitro
in
vivo
studies
highlight
strengthen
control
inflammation,
making
them
candidates
managing
diseases.
However,
further
research
is
needed
standardize
formulations,
determine
optimal
dosages,
validate
safety
efficacy
clinical
settings.
Addressing
these
gaps
will
support
integration
herbal
into
evidence-based
healthcare
as
sustainable
immune-enhancing
strategies.
Materials Technology,
Год журнала:
2025,
Номер
40(1)
Опубликована: Март 21, 2025
Oral
pathogen
biofilms
contribute
to
chronic
infections,
while
oral
cancer
remains
a
significant
health
threat,
emphasizing
the
need
for
effective
therapeutic
strategies.
This
study
investigates
fabrication,
characterization,
and
potential
of
copper
oxide-stigmasterol
nanoparticles
(CuO-SS
NPs)
biofilm
disruption
treatment.
The
antimicrobial
activity
CuO-SS
NPs
was
evaluated
against
pathogens,
including
S.
aureus,
mutans,
E.
faecalis,
C.
albicans.
In
cell
studies,
exhibited
concentration-dependent
cytotoxicity,
reducing
viability
from
88%
at
15
µg/mL
29.33%
120
µg/mL,
comparable
doxorubicin
(24.3%).
significantly
upregulated
apoptosis
markers
(Caspase-3,
Caspase-8,
FasL)
by
4.05,
1.4,
3.1
fold,
respectively.
These
results
highlight
as
dual-purpose
infections
cancer.
American Journal of Cancer Research,
Год журнала:
2025,
Номер
15(3), С. 1109 - 1121
Опубликована: Янв. 1, 2025
β-Sitosterol
(BS),
is
a
significant
bioactive
component
of
phytosterols
found
in
plants,
foods,
and
dietary
supplements.
Its
nutritional
benefits
include
lowering
cholesterol
levels,
boost
immune
system
as
well
reduce
inflammation.
Previous
studies
have
demonstrated
its
anticancer
effects
across
various
human
cancers.
However,
the
specific
mechanisms
action
BS
lung
cancer
remain
unclear.
This
study
aimed
to
investigate
through
which
exerts
properties
cells,
focusing
on
anti-proliferative,
apoptotic,
cytotoxic,
anti-migratory
effects.
We
conducted
an
vitro
assess
cell
lines
A549
H1975.
used
range
assays,
including
MTT,
western
blot,
wound
healing,
transwell
migration,
immunofluorescence,
TUNEL,
survival
evaluate
impact
proliferation,
apoptosis,
cytotoxicity,
migration.
Our
findings
indicate
that
inhibits
proliferation
cells
time-
dose-dependent
manner.
It
significantly
promotes
apoptosis
impairs
both
migration
survival.
Additionally,
suppresses
expression
fibroblast
growth
factor
receptor-1
(FGFR1)
epidermal
(EGFR),
leading
downregulation
PI3K/AKT/mTOR/CD1
signaling
pathway.
demonstrates
potential
by
inhibiting
inducing
reducing
These
are
likely
mediated
concurrent
FGFR1
EGFR,
inhibition
pathway,
thereby
warranting
further
investigation
therapeutic
agent
for
cancer.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4732 - 4732
Опубликована: Окт. 7, 2024
Over
the
past
decade,
several
studies
have
established
a
direct
link
between
functional
foods,
nutraceuticals,
and
reduced
risk
of
oxidative-stress-related
diseases.
Nutraceuticals,
which
encompass
variety
bioactive
molecules,
exhibit
both
nutritional
therapeutic
properties.
The
cactus
pear
(
