Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1228 - 1228
Опубликована: Дек. 18, 2024
Biofilms
are
structured
microbial
communities
that
adhere
to
various
abiotic
and
biotic
surfaces,
where
organisms
encased
in
an
exo-polysaccharide
matrix.
Organisms
within
biofilms
use
mechanisms
help
them
resist
external
challenges,
such
as
antibiotics,
rendering
more
resistant
drugs.
Therefore,
researchers
have
attempted
develop
suitable
laboratory
models
study
the
physical
features
of
biofilms,
their
resistance
against
antimicrobial
agents,
gene
protein
expression
profiles.
However,
current
suffer
from
limitations.
In
this
comprehensive
review,
we
summarized
designs
been
used
for
biofilm
models,
presenting
strengths
Additionally,
provided
insight
into
improving
these
closely
simulate
real-life
scenarios,
using
newly
developed
techniques
additive
manufacturing,
synthetic
biology,
bioengineering.
Gels,
Год журнала:
2025,
Номер
11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Gels,
Год журнала:
2024,
Номер
10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101342 - 101342
Опубликована: Ноя. 14, 2024
Hydrogels,
that
are
crosslinked
polymer
networks,
can
absorb
huge
quantities
of
water
and/or
biological
fluids.
Their
physical
properties,
such
as
elasticity
and
soft
tissue,
together
with
their
biocompatibility
biodegradability,
closely
resemble
living
tissues.
The
versatility
hydrogels
has
fuelled
application
in
various
fields,
agriculture,
biomaterials,
the
food
industry,
drug
delivery,
tissue
engineering,
regenerative
medicine.
combination
nanoparticles,
specifically
Mesoporous
Silica
Nanoparticles
(MSNs),
have
elevated
these
composites
to
next
level,
since
MSNs
could
improve
hydrogel
mechanical
ability
encapsulate
controlled
release
great
amounts
different
therapeutic
agents,
responsiveness
a
variety
external
internal
stimuli.
In
this
review,
main
features
both
introduced,
followed
by
discussion
hydrogels-MSNs
structures
an
overview
use
applications,
delivery
technologies
engineering.
Abstract
Chronic
wounds
are
that
difficult
to
heal
or
do
not
follow
the
normal
healing
process.
These
include
pressure
ulcers,
diabetic
venous
and
arterial
incomplete
ulcers.
Unlike
acute
wounds,
chronic
often
even
heal.
Its
pathogenesis
involves
many
factors;
bacterial
infection
is
main
cause
of
wound.
With
increase
in
population
aging,
incidence
has
become
a
critical
issue
current
medical
health
field.
Management
faced
with
problems
long
treatment
time,
difficulty,
high
cost,
repeated
attacks
disability
rate,
which
seriously
threaten
patients'
ability
take
care
themselves
life
heavy
burden
individuals,
families
society.
Over
past
few
years,
development
antibacterial
hydrogels
for
infections
received
lot
attention.
Since
only
have
mechanical
properties
hydrogels,
biocompatibility
adjustable
functional
structure,
but
also
excellent
properties,
they
may
be
an
ideal
dressing
solve
problem
wound
healing.
This
article
introduces
types
their
characteristics,
challenges
treating
wounds.
It
classifies
antimicrobial
based
on
modes
further
discusses
advancements
smart
along
benefits
obstacles
using
explores
directions
management.
Biomimetics,
Год журнала:
2024,
Номер
9(7), С. 418 - 418
Опубликована: Июль 8, 2024
Biomimetic
gels
are
synthetic
materials
designed
to
mimic
the
properties
and
functions
of
natural
biological
systems,
such
as
tissues
cellular
environments.
This
manuscript
explores
advancements
future
directions
injectable
biomimetic
in
biomedical
applications
highlights
significant
potential
hydrogels
wound
healing,
tissue
regeneration,
controlled
drug
delivery
due
their
enhanced
biocompatibility,
multifunctionality,
mechanical
properties.
Despite
these
advancements,
challenges
resilience,
degradation
rates,
scalable
manufacturing
remain.
discusses
ongoing
research
optimize
properties,
develop
cost-effective
production
techniques,
integrate
emerging
technologies
like
3D
bioprinting
nanotechnology.
Addressing
through
collaborative
efforts
is
essential
for
unlocking
full
engineering
regenerative
medicine.
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Nanocomposite
hydrogels
offer
a
promising
approach
to
treating
diabetic
wounds.
Key
findings
include
enhanced
mechanical
properties,
antibacterial
effects,
and
the
ability
regulate
wound
microenvironment.
