Targeting Injectable Hydrogels: The Role of Diphenylalanine Peptide Derivative in the Gelation Dynamics of Pluronic® F127

Polymers, Год журнала: 2025, Номер 17(7), С. 930 - 930

Опубликована: Март 29, 2025

The fluorenyl methyl oxycarbonyl phenylalanyl-phenylalanine ester (Fmoc-Phe-Phe-Ome) was synthetized using the liquid phase synthesis strategy. This derivative separated by hydrophobic interaction chromatography, its purity analyzed RP-HPLC and it characterized mass spectrometry. extremely peptide conjugate incorporated into aqueous solutions of Pluronic® F127 at low temperatures (below 10 °C). temperature induced sol-gel transition investigated rheological measurements. A delay transition, caused presence concentrations Fmoc-Phe-Phe-Ome (up to 1%), enables better control gelation process. viscoelastic properties hybrid networks were 37 °C in different shear conditions. Pluronic/peptide systems reported herein provide promising alternatives for developing innovative injectable gels as suitable platforms cancer treatment.

Язык: Английский

Fundamental and Application of Co-assembly of Peptides and Proteins: Experiment and Computation

Supramolecular Materials, Год журнала: 2025, Номер unknown, С. 100103 - 100103

Опубликована: Апрель 1, 2025

Язык: Английский