Targeting Injectable Hydrogels: The Role of Diphenylalanine Peptide Derivative in the Gelation Dynamics of Pluronic® F127

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 930 - 930

Published: March 29, 2025

The fluorenyl methyl oxycarbonyl phenylalanyl-phenylalanine ester (Fmoc-Phe-Phe-Ome) was synthetized using the liquid phase synthesis strategy. This derivative separated by hydrophobic interaction chromatography, its purity analyzed RP-HPLC and it characterized mass spectrometry. extremely peptide conjugate incorporated into aqueous solutions of Pluronic® F127 at low temperatures (below 10 °C). temperature induced sol-gel transition investigated rheological measurements. A delay transition, caused presence concentrations Fmoc-Phe-Phe-Ome (up to 1%), enables better control gelation process. viscoelastic properties hybrid networks were 37 °C in different shear conditions. Pluronic/peptide systems reported herein provide promising alternatives for developing innovative injectable gels as suitable platforms cancer treatment.

Language: Английский

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Fundamental and Application of Co-assembly of Peptides and Proteins: Experiment and Computation

Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100103 - 100103

Published: April 1, 2025

Language: Английский

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Application of a Dopa Derivative for the Formation of Gels in the Presence of Commercial Surfactants

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 320 - 320

Published: April 25, 2025

Cosmetic formulations are complex mixtures of ingredients that must fulfill several requirements. One the challenges cosmetic industry is to find natural alternatives replace synthetic polymers, preserving desirable sensory characteristics. The aim this work induce formation gels, by replacing polymers with a low-molecular-weight gelator (LMWG), small molecule able self-assemble and form supramolecular networks. impact gelators on environment reduced as they highly biodegradable. Thus, behavior solutions containing Boc-L-Dopa(Bn)2-OH, an LMWG, together ten different anionic surfactants, was studied understand if LMWG may act rheological modifier increasing viscosity formulation or forming gels these ingredients. An amphoteric surfactant, cocamidopropyl betaine (CAPB), often used increase cleansing gentleness, also added better mimic formulation. In most cases, addition at only 1% w/v concentration induces gelification in solutions, thus showing mixtures.

Language: Английский

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Linking Microscopic Network Structure to Macroscopic Rheological Properties in Polydimethylsiloxane Composite Fluids

Composites Science and Technology, Journal Year: 2025, Volume and Issue: 267, P. 111193 - 111193

Published: April 28, 2025

Language: Английский

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