Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings
Gels,
Год журнала:
2024,
Номер
10(2), С. 147 - 147
Опубликована: Фев. 14, 2024
Wound
healing
is
a
physiological
process
occurring
after
the
onset
of
skin
lesion
aiming
to
reconstruct
dermal
barrier
between
external
environment
and
body.
Depending
on
nature
duration
process,
wounds
are
classified
as
acute
(e.g.,
trauma,
surgical
wounds)
chronic
diabetic
ulcers)
wounds.
The
latter
take
several
months
heal
or
do
not
(non-healing
wounds),
usually
prone
microbial
infection
represent
an
important
source
morbidity
since
they
affect
millions
people
worldwide.
Typical
wound
treatments
comprise
debridement,
grafts/flaps)
non-surgical
topical
formulations,
dressings)
methods.
Modern
experimental
approaches
include
among
others
three
dimensional
(3D)-(bio)printed
dressings.
present
paper
reviews
recently
developed
3D
(bio)printed
hydrogels
for
applications,
especially
focusing
results
their
in
vitro
vivo
assessment.
advanced
hydrogel
constructs
were
printed
using
different
types
bioinks
natural
and/or
synthetic
polymers
mixtures
with
biological
materials)
printing
methods
extrusion,
digital
light
processing,
coaxial
microfluidic
bioprinting,
etc.)
incorporated
various
bioactive
agents
growth
factors,
antibiotics,
antibacterial
agents,
nanoparticles,
cells
fibroblasts,
keratinocytes,
mesenchymal
stem
cells,
endothelial
etc.).
Язык: Английский
Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review
Diego De León-Oliva,
Diego Liviu Boaru,
Roque Emilio Perez-Exposito
и другие.
Gels,
Год журнала:
2023,
Номер
9(11), С. 885 - 885
Опубликована: Ноя. 8, 2023
Bone
and
cartilage
tissue
play
multiple
roles
in
the
organism,
including
kinematic
support,
protection
of
organs,
hematopoiesis.
and,
above
all,
cartilaginous
tissues
present
an
inherently
limited
capacity
for
self-regeneration.
The
increasing
prevalence
disorders
affecting
these
crucial
tissues,
such
as
bone
fractures,
metastases,
osteoporosis,
or
osteoarthritis,
underscores
urgent
imperative
to
investigate
therapeutic
strategies
capable
effectively
addressing
challenges
associated
with
their
degeneration
damage.
In
this
context,
emerging
field
engineering
regenerative
medicine
(TERM)
has
made
important
contributions
through
development
advanced
hydrogels.
These
crosslinked
three-dimensional
networks
can
retain
substantial
amounts
water,
thus
mimicking
natural
extracellular
matrix
(ECM).
Hydrogels
exhibit
exceptional
biocompatibility,
customizable
mechanical
properties,
ability
encapsulate
bioactive
molecules
cells.
addition,
they
be
meticulously
tailored
specific
needs
each
patient,
providing
a
promising
alternative
conventional
surgical
procedures
reducing
risk
subsequent
adverse
reactions.
However,
some
issues
need
addressed,
lack
strength,
inconsistent
low-cell
viability.
This
review
describes
structure
regeneration
tissue.
Then,
we
overview
hydrogels,
classification,
synthesis,
biomedical
applications.
Following
this,
most
relevant
recent
hydrogels
TERM
regeneration.
Язык: Английский
New Insights in Hydrogels for Periodontal Regeneration
Journal of Functional Biomaterials,
Год журнала:
2023,
Номер
14(11), С. 545 - 545
Опубликована: Ноя. 11, 2023
Periodontitis
is
a
destructive
inflammatory
disease
characterized
by
microbial
infection
that
damages
the
tissues
supporting
tooth
(alveolar
bone,
gingiva,
periodontal
ligament,
and
cementum),
ultimately
resulting
in
loss
of
teeth.
The
ultimate
goal
therapy
to
achieve
regeneration
all
tissues.
Thus,
tissue
engineering
approaches
have
been
evolving
from
simple
membranes
or
grafts
more
complex
constructs.
Hydrogels
are
highly
hydrophilic
polymeric
networks
with
ability
simulate
natural
microenvironment
cells.
In
particular,
hydrogels
offer
several
advantages
when
compared
other
forms
scaffolds,
such
as
mimicry
sustained
drug
delivery.
Moreover,
can
maintain
moist
environment
similar
oral
cavity.
allow
for
precise
placement
retention
regenerative
materials
at
defect
site,
minimizing
potential
off-target
effects
ensuring
treatment
focused
on
specific
site.
As
mechanism
action,
release
drugs
presented
allows
control
reducing
inflammation
attracting
host
cells
Several
therapeutic
agents,
antibiotics,
anti-inflammatory
osteogenic
drugs,
loaded
into
hydrogels,
presenting
effective
benefits
health
allowing
release.
This
review
discusses
causes
consequences
disease,
well
limitations
current
treatments
applied
clinics.
main
components
discussed
focusing
their
different
characteristics,
outcomes,
strategies
Novel
methods
fabrication
highlighted,
clinical
studies
regarding
applications
reviewed.
Finally,
research
discussed,
future
directions
proposed.
Язык: Английский
Conclusion and future prospects of cellulose-based hydrogels
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 459 - 476
Опубликована: Янв. 1, 2025
Язык: Английский
Bioprinted hydrogels in bone regeneration: a bibliometric analysis
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 3, 2025
Background
The
application
of
bioprinted
hydrogels
in
the
field
bone
regeneration
is
garnering
increasing
attention.
objective
this
study
to
provide
a
comprehensive
overview
current
research
status,
hotspots
and
directions
through
bibliometric
methods,
predict
development
trend
field.
Methods
A
search
was
conducted
on
27
December
2024,
for
papers
published
Web
Science
from
2010
2025.
We
used
bibliometrix
package
software
program
R
analyze
retrieved
data
VOSviewer
CiteSpace
visualize
trends
regeneration.
Results
identified
reviewed
684
articles
between
total
811
institutions
1,166
researchers
41
countries/regions
contributed
these
publications.
Among
them,
China
led
terms
number
published,
single-country
publications
(SCP),
multi-country
(MCP).
Our
bibliometric-based
visualization
analysis
revealed
that
mechanical
properties
osteogenic
differentiation
capacity
biomaterials
have
been
focal
topic
over
past
decade,
while
emerging
has
also
concentrated
vitro
fabrication
stem
cells
differentiation,
particularly
precise
situ
cell-loaded
organoids.
Conclusion
This
provides
an
in-depth
trajectory
annually,
main
include
regeneration,
3D
printing,
scaffolds,
hydrogels.
Future
may
focus
gelatin,
additive
manufacturing,
growth
factors.
Additionally,
international
collaboration
essential
enhance
effectiveness
applications.
Язык: Английский
Antimicrobial Biomaterial for Dental Healthcare Application
Опубликована: Янв. 1, 2025
Язык: Английский
Development of HEMA‐Succinic Acid‐PEG Bio‐Based Monomers for High‐Performance Hydrogels in Regenerative Medicine
Biopolymers,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 9, 2024
ABSTRACT
In
recent
years,
hydrogels
have
found
a
special
place
in
regenerative
medicine
for
tissue
repair,
rehabilitation,
and
drug
delivery.
To
be
used
medicine,
must
desirable
physical,
chemical,
biological
properties.
this
study,
new
biomonomer
based
on
hydroxyethyl
methacrylate‐succinic
acid‐polyethylene
glycol
200
(HEMA‐Suc‐PEG)
was
synthesized
characterized.
Then,
using
the
monomers
different
ratios
of
polyethylene
diacrylate
(PEGDA)
as
crosslinker,
biocompatible
were
through
thermal
UV
curing
methods.
The
mechanical,
properties
behavior
endothelial
cells,
an
essential
component
cardiovascular
system,
evaluated.
results
showed
that
hydrogel
with
0.2
g
PEGDA
(UV
curing)
has
mechanical
physical
Biological
tests
these
are
not
only
nontoxic
to
cells
but
also
enhance
cell
adhesion.
Therefore,
containing
monomer
HEMA‐Suc‐PEG
potential
system.
Язык: Английский
An Innovative Delivery System of Oxygen-Releasing Nanospheres and Self-Healing Hydrogels Enhances the Therapeutic Effectiveness of Bone Marrow Mesenchymal Stem Cells for Chronic Limb-Threatening Ischemia
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12153 - 12170
Опубликована: Ноя. 1, 2024
Bone
marrow
mesenchymal
stem
cells
(BMSCs)
have
emerged
as
promising
candidate
for
postoperative
therapeutics
in
chronic
limb-threatening
ischemia
(CLTI).
Nevertheless,
their
effectiveness
is
limited
by
low
survival
rate
and
impaired
functionality
the
ischemic
microenvironment.
To
overcome
these
challenges,
we
devised
an
innovative
delivery
approach
to
support
utilization
of
BMSCs
CLTI
therapy.
Язык: Английский
Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells
Gengxu Han,
Fangshen Li,
Bin Yu
и другие.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 30, 2024
Abstract
Lymphocytes
are
crucial
to
defend
against
harmful
pathogens
and
sustain
adaptive
immunity.
Developing
immunomodulating
materials
activate
lymphocytes
is
imperative
induce
effective
enduring
immune
responses.
Here,
a
new
polymer
serving
as
highly
efficient
activator
of
B
cells
reported
corresponding
spheres
synthesized
through
droplet‐assisted
ternary
copolymerization
process
ascorbic
acid,
ethylenediamine,
glyoxal.
In‐depth
studies
conducted
on
the
polymerization
mechanisms
ranging
from
250
1200
nm
with
various
surface
functional
groups
synthesized.
These
prepared
exhibit
remarkable
immunomodulatory
functions
correlated
spheres'
size
groups,
activations
observed
in
vivo
vitro.
Through
cell
phagocytosis
experiments
RNA
sequencing
analysis,
it
proposed
that
selective
presence
CD21
membrane
contribute
activation
cells.
This
work
has
extended
realm
immunological
research
unique
perspective
chemical
synthesis,
further
substantiating
fundamental
application
potential
designing
polymers.
Язык: Английский