Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells DOI

Gengxu Han,

Fangshen Li,

Bin Yu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Abstract Lymphocytes are crucial to defend against harmful pathogens and sustain adaptive immunity. Developing immunomodulating materials activate lymphocytes is imperative induce effective enduring immune responses. Here, a new polymer serving as highly efficient activator of B cells reported corresponding spheres synthesized through droplet‐assisted ternary copolymerization process ascorbic acid, ethylenediamine, glyoxal. In‐depth studies conducted on the polymerization mechanisms ranging from 250 1200 nm with various surface functional groups synthesized. These prepared exhibit remarkable immunomodulatory functions correlated spheres' size groups, activations observed in vivo vitro. Through cell phagocytosis experiments RNA sequencing analysis, it proposed that selective presence CD21 membrane contribute activation cells. This work has extended realm immunological research unique perspective chemical synthesis, further substantiating fundamental application potential designing polymers.

Language: Английский

Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings DOI Creative Commons
Olga Kammona, Evgenia Tsanaktsidou, Costas Kiparissides

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(2), P. 147 - 147

Published: Feb. 14, 2024

Wound healing is a physiological process occurring after the onset of skin lesion aiming to reconstruct dermal barrier between external environment and body. Depending on nature duration process, wounds are classified as acute (e.g., trauma, surgical wounds) chronic diabetic ulcers) wounds. The latter take several months heal or do not (non-healing wounds), usually prone microbial infection represent an important source morbidity since they affect millions people worldwide. Typical wound treatments comprise debridement, grafts/flaps) non-surgical topical formulations, dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed dressings. present paper reviews recently developed 3D (bio)printed hydrogels for applications, especially focusing results their in vitro vivo assessment. advanced hydrogel constructs were printed using different types bioinks natural and/or synthetic polymers mixtures with biological materials) printing methods extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) incorporated various bioactive agents growth factors, antibiotics, antibacterial agents, nanoparticles, cells fibroblasts, keratinocytes, mesenchymal stem cells, endothelial etc.).

Language: Английский

Citations

16
Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review DOI Creative Commons

Diego De León-Oliva,

Diego Liviu Boaru,

Roque Emilio Perez-Exposito

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(11), P. 885 - 885

Published: Nov. 8, 2023

Bone and cartilage tissue play multiple roles in the organism, including kinematic support, protection of organs, hematopoiesis. and, above all, cartilaginous tissues present an inherently limited capacity for self-regeneration. The increasing prevalence disorders affecting these crucial tissues, such as bone fractures, metastases, osteoporosis, or osteoarthritis, underscores urgent imperative to investigate therapeutic strategies capable effectively addressing challenges associated with their degeneration damage. In this context, emerging field engineering regenerative medicine (TERM) has made important contributions through development advanced hydrogels. These crosslinked three-dimensional networks can retain substantial amounts water, thus mimicking natural extracellular matrix (ECM). Hydrogels exhibit exceptional biocompatibility, customizable mechanical properties, ability encapsulate bioactive molecules cells. addition, they be meticulously tailored specific needs each patient, providing a promising alternative conventional surgical procedures reducing risk subsequent adverse reactions. However, some issues need addressed, lack strength, inconsistent low-cell viability. This review describes structure regeneration tissue. Then, we overview hydrogels, classification, synthesis, biomedical applications. Following this, most relevant recent hydrogels TERM regeneration.

Language: Английский

Citations

13
New Insights in Hydrogels for Periodontal Regeneration DOI Creative Commons
Mafalda S. Santos,

Alexandra B. dos Santos,

Marta S. Carvalho

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(11), P. 545 - 545

Published: Nov. 11, 2023

Periodontitis is a destructive inflammatory disease characterized by microbial infection that damages the tissues supporting tooth (alveolar bone, gingiva, periodontal ligament, and cementum), ultimately resulting in loss of teeth. The ultimate goal therapy to achieve regeneration all tissues. Thus, tissue engineering approaches have been evolving from simple membranes or grafts more complex constructs. Hydrogels are highly hydrophilic polymeric networks with ability simulate natural microenvironment cells. In particular, hydrogels offer several advantages when compared other forms scaffolds, such as mimicry sustained drug delivery. Moreover, can maintain moist environment similar oral cavity. allow for precise placement retention regenerative materials at defect site, minimizing potential off-target effects ensuring treatment focused on specific site. As mechanism action, release drugs presented allows control reducing inflammation attracting host cells Several therapeutic agents, antibiotics, anti-inflammatory osteogenic drugs, loaded into hydrogels, presenting effective benefits health allowing release. This review discusses causes consequences disease, well limitations current treatments applied clinics. main components discussed focusing their different characteristics, outcomes, strategies Novel methods fabrication highlighted, clinical studies regarding applications reviewed. Finally, research discussed, future directions proposed.

Language: Английский

Citations

13
Conclusion and future prospects of cellulose-based hydrogels DOI
Nilutpal Sharma Bora,

Bhaswati Kashyap,

Shaswat Barua

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 459 - 476

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bioprinted hydrogels in bone regeneration: a bibliometric analysis DOI Creative Commons

Huijie Zhang,

Xiaoyu Li, Zhenyu Jia

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background The application of bioprinted hydrogels in the field bone regeneration is garnering increasing attention. objective this study to provide a comprehensive overview current research status, hotspots and directions through bibliometric methods, predict development trend field. Methods A search was conducted on 27 December 2024, for papers published Web Science from 2010 2025. We used bibliometrix package software program R analyze retrieved data VOSviewer CiteSpace visualize trends regeneration. Results identified reviewed 684 articles between total 811 institutions 1,166 researchers 41 countries/regions contributed these publications. Among them, China led terms number published, single-country publications (SCP), multi-country (MCP). Our bibliometric-based visualization analysis revealed that mechanical properties osteogenic differentiation capacity biomaterials have been focal topic over past decade, while emerging has also concentrated vitro fabrication stem cells differentiation, particularly precise situ cell-loaded organoids. Conclusion This provides an in-depth trajectory annually, main include regeneration, 3D printing, scaffolds, hydrogels. Future may focus gelatin, additive manufacturing, growth factors. Additionally, international collaboration essential enhance effectiveness applications.

Language: Английский

Citations

0
Antimicrobial Biomaterial for Dental Healthcare Application DOI
Bhupinder Singh, Rishabha Malviya, Christian Kaunert

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development of HEMA‐Succinic Acid‐PEG Bio‐Based Monomers for High‐Performance Hydrogels in Regenerative Medicine DOI
Hossein Rayat Pisheh,

Alireza Sabzevari,

Mojtaba Ansari

et al.

Biopolymers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

ABSTRACT In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used medicine, must desirable physical, chemical, biological properties. this study, new biomonomer based on hydroxyethyl methacrylate‐succinic acid‐polyethylene glycol 200 (HEMA‐Suc‐PEG) was synthesized characterized. Then, using the monomers different ratios of polyethylene diacrylate (PEGDA) as crosslinker, biocompatible were through thermal UV curing methods. The mechanical, properties behavior endothelial cells, an essential component cardiovascular system, evaluated. results showed that hydrogel with 0.2 g PEGDA (UV curing) has mechanical physical Biological tests these are not only nontoxic to cells but also enhance cell adhesion. Therefore, containing monomer HEMA‐Suc‐PEG potential system.

Language: Английский

Citations

1
An Innovative Delivery System of Oxygen-Releasing Nanospheres and Self-Healing Hydrogels Enhances the Therapeutic Effectiveness of Bone Marrow Mesenchymal Stem Cells for Chronic Limb-Threatening Ischemia DOI Creative Commons
M W Zhao, Zixuan Zhou, Amir Sherchan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12153 - 12170

Published: Nov. 1, 2024

Bone marrow mesenchymal stem cells (BMSCs) have emerged as promising candidate for postoperative therapeutics in chronic limb-threatening ischemia (CLTI). Nevertheless, their effectiveness is limited by low survival rate and impaired functionality the ischemic microenvironment. To overcome these challenges, we devised an innovative delivery approach to support utilization of BMSCs CLTI therapy.

Language: Английский

Citations

1
Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells DOI

Gengxu Han,

Fangshen Li,

Bin Yu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Abstract Lymphocytes are crucial to defend against harmful pathogens and sustain adaptive immunity. Developing immunomodulating materials activate lymphocytes is imperative induce effective enduring immune responses. Here, a new polymer serving as highly efficient activator of B cells reported corresponding spheres synthesized through droplet‐assisted ternary copolymerization process ascorbic acid, ethylenediamine, glyoxal. In‐depth studies conducted on the polymerization mechanisms ranging from 250 1200 nm with various surface functional groups synthesized. These prepared exhibit remarkable immunomodulatory functions correlated spheres' size groups, activations observed in vivo vitro. Through cell phagocytosis experiments RNA sequencing analysis, it proposed that selective presence CD21 membrane contribute activation cells. This work has extended realm immunological research unique perspective chemical synthesis, further substantiating fundamental application potential designing polymers.

Language: Английский

Citations

0