Russian Journal of Bioorganic Chemistry, Год журнала: 2024, Номер 50(6), С. 2397 - 2425
Опубликована: Дек. 1, 2024
Язык: Английский
Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 290 - 290
Опубликована: Фев. 20, 2025
Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(10), С. 7229 - 7254
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
4
ACS Omega, Год журнала: 2025, Номер 10(7), С. 6857 - 6875
Опубликована: Фев. 12, 2025
This study explores a novel approach to managing skin conditions through combination therapy utilizing phospholipid-enriched edge activator-based nanoformulation. 5-Fluorouracil (5-FU)- and sesamol (SES)-loaded transliposomes (FS-TL) were developed using thin film hydration method optimized Box-Behnken Design. FS-TL characterization indicated vesicle size of 165.6 ± 1.1 nm, polydispersity index 0.28 0.01, zeta potential −33.17 0.9 mV, the percent entrapment efficiencies for 5-FU SES found be 63.16 1.07% 75.60 3.68%, respectively. The drug loading percents 5.87 0.099% 7.03 0.34%, morphological studies exhibit distinctive spherical shape in vitro release demonstrated sustained with 82.52 1.2% 86.28 1.3% releases SES, ex vivo permeation exhibited 81.04 2.1% 78.03 1.7% SES. Confocal laser microscopy scanning (CLSM) revealed deeper formulation penetration (30.0 μm) excised mice membranes than standard rhodamine solution (10.0 μm). dermatokinetic investigation that gel has significantly higher concentrations (p < 0.001). efficacy 0.05) eradicating A431 melanoma cell line was satisfactory. These findings suggest over conventional approaches cancer management.
Язык: Английский
Процитировано
0
International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 240 - 249
Опубликована: Март 7, 2025
Objective: The current study aims to develop and validate a simple, accurate, precise, robust Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method estimate hesperidin piperine in an ethosomal formulation simultaneously. This is intended support the characterization of novel designed enhance transdermal delivery piperine. Methods: Chromatographic separation was done using C18 column (250×4.6 mm) featuring 5 μm particle size, maintained at 25 °C) with Photodiode Array (PDA) detector. mobile phase consisted mixture methanol, Acetonitrile (ACN), water (70:20:10 v/v, pH 3.2). Separation performed flow rate 0.8 ml/min 10 µl injection volume. All detection isosbestic wavelength 291 nm. Results: Hesperidin were eluted retention time 3.15 5.40 min, respectively. developed RP-HPLC demonstrated excellent accuracy, precision, linearity for simultaneous quantification According guidelines, optimized exhibited size 208.4±0.3 nm, Polydispersity Index (PDI) 0.1294, high entrapment efficiencies hesperidin: 94.14±0.13%, piperine: 79.57±0.11%. In vitro drug release found be 87.27±2.56% 83.95±5.32% Conclusion: HPLC could used measure both simultaneously ethosomes other nanoparticle-based formulations. desirable characteristics delivery, including sustained property good efficiency.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Innovation, Год журнала: 2024, Номер 19(5)
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
3
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105825 - 105825
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
2
Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 19
Опубликована: Июль 26, 2024
Transethosomes, a fusion of transferosomes and ethosomes, combine the advantageous attributes both vesicular systems to enhance deformability skin permeation. While delivery is effective for drug transport, overcoming barrier remains significant challenge, particularly plant-based products with poor permeability. Transethosomes offer promising solution, but their low viscosity retention on surfaces led development transethosomal gels. These gels can entrap unstable high molecular weight herbal extracts, fractions bioactive compounds, facilitating enhanced inner layers skin. This review focuses superior performance transethosomes compared conventional lipid-based nanovesicular systems, offering an advanced approach transdermal drugs improved permeability stability.
Язык: Английский
Процитировано
2
Frontiers in Bioinformatics, Год журнала: 2024, Номер 4
Опубликована: Июль 26, 2024
This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from
Язык: Английский
Процитировано
2
Micro and Nanosystems, Год журнала: 2024, Номер 16(4), С. 219 - 233
Опубликована: Авг. 2, 2024
Objective: The goal of the current study was to formulate and evaluate bilastine-loaded transethosomal nanogel. Bilastine has 60% oral bioavailability, which restricts rate absorption dissolution classifies it under BCS class II drugs, can be overcome by incorporating bilastine in nanogel formulation treatment urticaria. Methods: Bilastine-loaded transethosomes were prepared using a thin film hydration method with different proportions Tween 80 ethanol rotary evaporator incorporated into gel Carbopol 934 as polymer dispersion method. Results: optimized “Box Behnken design” evaluated for various parameters. found stable, determined zeta potential −27.0 mV polydispersity index (PDI) 0.167, vesicle size 183nm exhibiting maximum entrapment efficiency up 80.23%. drug content 81.56%. best results obtained 1% (TF7G2). batch showed prolonged in-vitro release 8 hrs. Ex vivo skin permeation studies 76.23 ± 2.63% comparison plain gel. Conclusion: Transethosomal batches based on content, viscosity, uniformity potential, spreadability, pH, release, stability testing, good results. this investigation that loaded might used improve delivery through greater bioavailability.
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11415 - 11432
Опубликована: Ноя. 1, 2024
Atorvastatin (ATV), a medication used to reduce cholesterol levels, possesses properties that can counteract the damaging effects of free radicals and inflammation. However, administration ATV orally is associated with low systemic bioavailability due its limited capacity dissolve in water significant first-pass effect. This study aimed assess appropriateness employing nano-vesicles for transdermal order enhance anti-inflammatory effects.
Язык: Английский
Процитировано
0