Expert Opinion on Drug Delivery,
Год журнала:
2020,
Номер
18(3), С. 369 - 382
Опубликована: Окт. 13, 2020
Introduction
Nanodiamond
(ND)
refers
to
diamond
particles
with
sizes
from
few
near
100
nanometers.
For
its
superb
physical,
chemical
and
spectroscopic
properties,
it
has
been
proposed
studied
the
aims
for
bio
imaging
drug
delivery.
Many
modalities
on
conjugating
molecules
ND
form
ND-X
more
efficient
delivery
have
demonstrated
in
cellular
animal
models.Area
covered
novel
approaches
utilizing
nanodiamond
as
a
platform
recently.
This
review
summarizes
recent
developments
facilitated
delivery,
complexes
preparations
tests
models.
The
outlook
clinical
translation
is
discussed.Expert
opinion
(ND-X)
produced
different
methods
are
realized
delivery;
almost
all
studies
reported
being
compared
pure
alone.
However,
of
particle
size
less
than
10
nm
found
toxic
due
surface
structure,
strongly
aggregate.
In
vivo
demonstrate
accumulation
organs
no
confirmed
long-term
effect
their
release
available.
Standardized
materials
needed
advance
applications
level.
Cancer Cell International,
Год журнала:
2021,
Номер
21(1)
Опубликована: Авг. 10, 2021
Abstract
Triple-negative
breast
cancer
(TNBC)
is
not
as
prevalent
hormone
receptor
or
HER2-positive
cancers
and
all
tests
come
back
negative.
More
importantly,
the
heterogeneity
complexity
of
TNBC
on
molecular
clinical
levels
have
limited
successful
development
novel
therapeutic
strategies
led
to
intrinsic
developed
resistance
chemotherapies
new
agents.
Studies
demonstrated
deregulation
Wnt/β-catenin
signaling
in
tumorigenesis
which
plays
decisive
roles
at
low
survival
rate
patients
facilitates
currently
existing
therapies.
This
review
summarizes
mechanisms
for
TNBC,
complex
interaction
between
signaling,
transactivated
tyrosine
kinase
(RTK)
pathways,
lymphocytic
infiltration,
epithelial-mesenchymal
transition
(EMT),
induction
metastasis.
Such
associations
how
these
pathways
interact
progression
careful
analysis
effective
combination
therapies
without
generating
significant
toxicity
resistance.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Март 20, 2021
Abstract
Background
Triple-negative
breast
cancer
(TNBC)
is
a
kind
of
aggressive
with
high
rate
metastasis,
poor
overall
survival
time,
and
low
response
to
targeted
therapies.
To
improve
the
therapeutic
efficacy
overcome
drug
resistance
TNBC
treatments,
here
we
developed
cell
membrane-coated
oxygen
delivery
nanoprobe,
CCm–HSA–ICG–PFTBA,
which
can
hypoxia
at
tumor
sites
enhance
photodynamic
therapy
(PDT),
resulting
in
relieving
growth
xenografts.
Results
The
size
CCm–HSA–ICG–PFTBA
was
131.3
±
1.08
nm.
vitro
1
O
2
ROS
concentrations
group
were
both
significantly
higher
than
those
other
groups
(
P
<
0.001).
In
vivo
fluorescence
imaging
revealed
that
best
time
window
24
h
post-injection
CCm–HSA–ICG–PFTBA.
Both
18
F-FMISO
PET
ex
immunofluorescence
staining
results
exhibited
improved
For
PDT
treatment,
volume
weight
NIR
smallest
among
all
decreased
compared
untreated
0.01).
No
obvious
biotoxicity
observed
by
injection
till
14
days.
Conclusions
By
using
solubility
perfluorocarbon
(PFC)
homologous
targeting
ability
membranes,
target
tissues,
mitigate
microenvironment,
Furthermore,
HSA,
ICG,
PFC
are
FDA-approved
materials,
render
nanoparticles
highly
biocompatible
potential
for
clinical
translation
treatment
patients.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Май 19, 2021
Abstract
Background
Triple
negative
breast
cancer
(TNBC)
is
an
aggressive
tumor
with
extremely
high
mortality
that
results
from
its
lack
of
effective
therapeutic
targets.
As
adhesion
molecule
related
to
tumorigenesis
and
metastasis,
cluster
differentiation-44
(also
known
as
CD44)
overexpressed
in
TNBC.
Moreover,
CD44
can
be
effectively
targeted
by
a
specific
hyaluronic
acid
analog,
namely,
chitosan
oligosaccharide
(CO).
In
this
study,
CO-coated
liposome
was
designed,
Photochlor
(HPPH)
the
660
nm
light
mediated
photosensitizer
evofosfamide
TH302)
hypoxia-activated
prodrug.
The
obtained
liposomes
help
diagnose
TNBC
fluorescence
imaging
produce
antitumor
therapy
synergetic
photodynamic
(PDT)
chemotherapy.
Results
Compared
nontargeted
liposomes,
exhibited
good
biocompatibility
targeting
capability
vitro;
vivo,
much
better
capability.
Additionally,
loaded
HPPH
TH302
showed
significantly
effects
than
other
monotherapy
groups
both
vitro
vivo.
Conclusion
impressive
synergistic
effects,
together
superior
capability,
minor
side
confers
potential
for
future
translational
research
diagnosis
CD44-overexpressing
therapy,
especially
Graphic
abstract
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 25, 2022
Cancer
is
a
life-threatening
disease,
contributing
approximately
9.4
million
deaths
worldwide.
To
address
this
challenge,
scientific
researchers
have
investigated
molecules
that
could
act
as
speed-breakers
for
cancer.
As
an
abiotic
drug
delivery
system,
liposomes
can
hold
both
hydrophilic
and
lipophilic
drugs,
which
promote
controlled
release,
accumulate
in
the
tumor
microenvironment,
achieve
elongated
half-life
with
enhanced
safety
profile.
further
improve
impair
off-target
effect,
surface
of
be
modified
way
easily
identified
by
cancer
cells,
promotes
uptake,
facilitates
angiogenesis.
Integrins
are
overexpressed
on
upon
activation
downstream
cell
signaling
eventually
activate
specific
pathways,
promoting
growth,
proliferation,
migration.
RGD
peptides
recognized
integrin
over
expressed
cells.
Just
like
multistage
rocket,
ligand
anchored
selectively
target
at
site,
finally,
release
desired
way.
This
review
highlights
role
development,
so
gain
more
insights
into
phenomenon
initiation
survival.
Since
family,
fate
has
been
demonstrated
after
its
binding
acceptor’s
family.
The
based
targeting
various
cells
also
highlighted
paper.
Technology in Cancer Research & Treatment,
Год журнала:
2023,
Номер
22
Опубликована: Янв. 1, 2023
Breast
cancer
is
the
most
common
malignancy
and
second
cause
of
cancer-related
mortality
in
women.
Triple-negative
breast
cancers
do
not
express
estrogen
receptors,
progesterone
or
human
epidermal
growth
factor
receptor
2
have
a
higher
recurrence
rate,
greater
metastatic
potential,
lower
overall
survival
rate
than
those
other
cancers.
Treatment
triple-negative
challenging;
molecular-targeted
therapies
are
largely
ineffective
there
no
standard
treatment.
In
this
review,
we
evaluate
current
attempts
to
classify
based
on
their
molecular
features.
We
also
describe
promising
treatment
methods
with
different
advantages
discuss
genetic
biomarkers
prediction
tools.
Accurate
classification
critical
for
patient
risk
categorization,
decisions,
surveillance.
This
review
offers
new
ideas
more
effective
identifies
novel
targets
drug
development.
Triple
negative
breast
cancer
(TNBC)
has
a
expression
of
estrogen
receptors
(ER),
progesterone
(PR),
or
human
epidermal
growth
factor
(HER2).
The
survival
rate
for
TNBC
is
generally
worse
than
other
subtypes.
treatment
made
significant
advances,
but
certain
limitations
remain.
Treatment
can
be
challenging
since
the
disease
various
Individualized
therapy
recommended
rather
generalized
therapy,
given
genetic
variations
among
these
A
precise
and
effective
requires
identifying
prognostic
markers.
Depending
on
type
stage
TNBC,
patients
are
treated
with
therapeutic
interventions.
variety
options
available,
such
as
chemotherapy,
immunotherapy,
radiotherapy,
surgery.
Chemotherapy
most
common
options.
systemic
chemotherapy
using
drugs
anthracyclines
taxanes
in
neoadjuvant
adjuvant
settings.
Developing
resistance
to
anticancer
off
target
toxicity
primary
hindrances
chemotherapeutic
solutions
cancer.
It
imperative
that
researchers,
clinicians,
pharmaceutical
companies
work
together
develop
TNBC.
Several
studies
have
suggested
nanotechnology
potential
solution
problem
suboptimal
treatment.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114444 - 114444
Опубликована: Фев. 27, 2023
Despite
significant
treatment
advances,
breast
cancer
remains
the
leading
cause
of
death
in
women.
From
current
situation,
addition
to
developing
chemoresistant
tumours,
distant
organ
metastasis,
and
recurrences,
patients
with
often
have
a
poor
prognosis.
Aptamers
as
"chemical
antibodies"
may
be
way
resolve
this
dilemma.
are
single-stranded,
non-coding
oligonucleotides
(DNA
or
RNA),
resulting
their
many
advantages,
including
stability
for
long-term
storage,
simplicity
synthesis
function,
low
immunogenicity,
high
degree
specificity
antidote.
gained
popularity
method
diagnosing
treating
specific
tumors
recent
years.
This
article
introduces
application
ten
different
aptamer
delivery
systems
diagnosis
cancer,
systematically
reviews
latest
research
progress
diagnosis.
It
provides
new
direction
clinical
cancer.
