Materials Today Advances,
Год журнала:
2023,
Номер
18, С. 100381 - 100381
Опубликована: Май 24, 2023
Bone
tissue
repair
is
influenced
by
the
synergistic
interaction
between
acute
immune
microenvironment
and
osteogenesis.
In
this
study
will
be
independently
film
dispersion
method
static
loading
shell
polymers
resveratrol
liposome
preparation
CS
-
Res
@
Lipo
(CRL)
microfluidic
technology
of
[email
protected]
hydrogel
microspheres
(MS)
condensation
reaction
chemical
grafting,
then
non-covalent
binding
site
MS
microsphere
was
used
to
skillfully
bind
BMP-2,
construct
procedural
release
(CRL
BMP
2
MS).
protected]@MS
inhibit
peak
rapidly
releasing
Res,
in
addition,
sustained
liberation
BMP-2
synchronizes
osteoimmunity
osteogenesis,
thereby
accelerating
bone
repair.
The
results
showed
that
released
with
an
increased
cumulative
rate
72.4
±
3.6%
first
24
h,
TNF-α
IL-1β
levels
were
significantly
decreased
4.27
times
3.65
as
compared
control
group,
respectively.
Furthermore,
continuous
approximately
40.26
6.8%
occurred
within
72
osteogenic
activity
group
2.98
2.82
times,
conclusion,
programmed
constructed
can
realize
linkage
immunity
dynamically
regulate
repair,
treatment
clinical
based
on
a
new
strategy
for
diagnosis
treatment.
Bioactive Materials,
Год журнала:
2023,
Номер
24, С. 401 - 437
Опубликована: Янв. 2, 2023
Despite
the
exceptional
progress
in
breast
cancer
pathogenesis,
prognosis,
diagnosis,
and
treatment
strategies,
it
remains
a
prominent
cause
of
female
mortality
worldwide.
Additionally,
although
chemotherapies
are
effective,
they
associated
with
critical
limitations,
most
notably
their
lack
specificity
resulting
systemic
toxicity
eventual
development
multi-drug
resistance
(MDR)
cells.
Liposomes
have
proven
to
be
an
invaluable
drug
delivery
system
but
multitudes
liposomal
systems
developed
every
year
only
few
been
approved
for
clinical
use,
none
which
employ
active
targeting.
In
this
review,
we
summarize
recent
strategies
actively
targeted
surface,
transmembrane
internal
cell
receptors,
enzymes,
direct
targeting
dual-targeting
cancer-associated
cells,
e.g.,
stem
cells
tumor
microenvironment,
etc.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Май 6, 2022
Abstract
Immunotherapy
has
gradually
emerged
as
the
most
promising
anticancer
therapy.
In
addition
to
conventional
anti-PD-1/PD-L1
therapy,
anti-CTLA-4
CAR-T
etc.,
immunotherapy
can
also
be
induced
by
stimulating
maturation
of
immune
cells
or
inhibiting
negative
cells,
regulating
tumor
microenvironment
and
cancer
vaccines.
Lipid
nanovesicle
drug
delivery
system
includes
liposomes,
cell
membrane
vesicles,
bacterial
outer
extracellular
vesicles
hybrid
vesicles.
nanovesicles
used
functional
for
immunotherapy,
carriers
deliver
drugs
site
immunotherapy.
Here,
we
review
recent
advances
in
five
kinds
lipid
assess
clinical
application
prospects
various
nanovesicles,
hoping
provide
valuable
information
translation
future.
Drug Discovery Today,
Год журнала:
2023,
Номер
29(1), С. 103851 - 103851
Опубликована: Дек. 12, 2023
Breast
cancer
is
the
most
common
and
malignant
tumor
among
women.
Chitosan
(CS)-based
nanoparticles
have
been
introduced
into
breast
therapy
as
a
way
to
increase
targeted
delivery
of
drugs
genes
site.
CS
nanostructures
suppress
tumorigenesis
by
enhancing
both
cargo
(drug
gene)
its
accumulation
in
cells.
The
cells
internalize
CS-based
through
endocytosis.
Moreover,
chitosan
nanocarriers
can
also
induce
phototherapy-mediated
ablation.
Smart
multifunctional
types
nanoparticles,
including
pH-,
light-
redox-responsive
be
used
improve
potential
for
removal.
In
addition,
acceleration
immunotherapy
has
achieved,
there
develop
CS-nanoparticle
hydrogels
that
tumorigenesis.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 489 - 503
Опубликована: Янв. 1, 2023
Background:
Central
nervous
system
tuberculosis
(CNS-TB)
is
the
most
devastating
form
of
extrapulmonary
tuberculosis.
Rifampin
(RIF)
a
first-line
antimicrobial
agent
with
potent
bactericidal
action.
Nonetheless,
blood-brain
barrier
(BBB)
limits
therapeutic
effects
on
CNS-TB.
Exosomes,
however,
can
facilitate
drug
movements
across
BBB.
In
addition,
exosomes
show
high
biocompatibility
and
drug-loading
capacity.
They
also
be
modified
to
increase
delivery
efficacy.
this
study,
we
loaded
RIF
into
brain-targeting
peptide
improve
BBB
permeability
RIF;
named
these
ANG-Exo-RIF.
Methods:
Exosomes
were
isolated
from
culture
medium
BMSCs
by
differential
ultracentrifugation
electroporation
ANG
chemical
reaction.
To
characterize
ANG-Exo-RIF,
Western
blot
(WB),
nanoparticle
tracking
analysis
(NTA)
transmission
electron
microscopy
(TEM)
performed.
Bend.3
cells
incubated
DiI
labeled
ANG-Exo-RIF
then
fluorescent
flow
cytometry
used
evaluate
targeting
ability
in
vitro.
Fluorescence
imaging
frozen
section
vivo.
MIC
MBC
determined
through
microplate
alamar
blue
assay
(MABA).
Results:
A
novel
exosome-based
was
developed.
Compared
untargeted
exosomes,
targeted
exhibited
capacity
vitro
The
0.25
μg/mL,
which
sufficient
meet
clinical
needs.
Conclusion:
summary,
excellent
ability,
antitubercular
activity
endow
potential
for
use
future
translation-aimed
research
provide
hope
an
effective
CNS-TB
treatment.
Graphical
Abstract:
Keywords:
exosome,
central
tuberculosis,
barrier,
rifampin
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116586 - 116586
Опубликована: Апрель 15, 2024
Cancer
treatment
is
presently
a
significant
challenge
in
the
medical
domain,
wherein
primary
modalities
of
intervention
include
chemotherapy,
radiation
therapy
and
surgery.
However,
these
therapeutic
carry
side
effects.
Photothermal
(PTT)
photodynamic
(PDT)
have
emerged
as
promising
for
tumors
recent
years.
Phototherapy
approach
that
involves
exposure
materials
to
specific
wavelengths
light,
which
can
subsequently
be
converted
into
either
heat
or
Reactive
Oxygen
Species
(ROS)
effectively
eradicate
cancer
cells.
Due
hydrophobicity
lack
targeting
many
photoresponsive
materials,
use
nano-carriers
their
transportation
has
been
extensively
explored.
Among
nanocarriers,
liposomes
identified
an
effective
drug
delivery
system
due
controllability
availability
biomedical
field.
By
binding
liposomes,
it
possible
reduce
cytotoxicity
material
regulate
release
accumulation
at
tumor
site.
This
article
provides
comprehensive
review
progress
made
using
loaded
onto
liposomes.
Additionally,
discusses
potential
synergistic
through
combination
phototherapy
with
chemo/immuno/gene
Abstract
Ferroptosis
therapy,
which
uses
ferroptosis
inducers
to
produce
lethal
lipid
peroxides
and
induce
tumor
cell
death,
is
considered
a
promising
cancer
treatment
strategy.
However,
challenges
remain
regarding
how
increase
the
accumulation
of
reactive
oxygen
species
(ROS)
in
microenvironment
(TME)
enhance
antitumor
efficacy.
In
this
study,
hyaluronic
acid
(HA)
encapsulated
hollow
mesoporous
manganese
dioxide
(H‐MnO
2
)
with
double‐shell
nanostructure
designed
contain
iron
coordinated
cyanine
near‐infrared
dye
IR783
(IR783‐Fe)
for
synergistic
photodynamic
therapy
against
tumors.
The
nano
photosensitizer
IR783‐Fe@MnO
‐HA,
HA
actively
targets
CD44
receptor,
subsequently
dissociates
releases
Fe
3+
acidic
TME.
First,
consumes
glutathione
2+
,
promotes
Fenton
reaction
cells
hydroxyl
free
radicals
(·OH)
cells.
addition,
MnO
catalyzes
production
O
from
H
enhances
singlet
(
1
by
under
laser
irradiation,
thus
increasing
ROS
provide
therapy.
highly
biocompatible
‐HA
nano‐photosensitizers
have
exhibited
tumor‐targeting
ability
efficient
inhibition
vivo
due
effect
therapies.
