Expert Opinion on Drug Delivery,
Год журнала:
2020,
Номер
18(3), С. 369 - 382
Опубликована: Окт. 13, 2020
Introduction
Nanodiamond
(ND)
refers
to
diamond
particles
with
sizes
from
few
near
100
nanometers.
For
its
superb
physical,
chemical
and
spectroscopic
properties,
it
has
been
proposed
studied
the
aims
for
bio
imaging
drug
delivery.
Many
modalities
on
conjugating
molecules
ND
form
ND-X
more
efficient
delivery
have
demonstrated
in
cellular
animal
models.Area
covered
novel
approaches
utilizing
nanodiamond
as
a
platform
recently.
This
review
summarizes
recent
developments
facilitated
delivery,
complexes
preparations
tests
models.
The
outlook
clinical
translation
is
discussed.Expert
opinion
(ND-X)
produced
different
methods
are
realized
delivery;
almost
all
studies
reported
being
compared
pure
alone.
However,
of
particle
size
less
than
10
nm
found
toxic
due
surface
structure,
strongly
aggregate.
In
vivo
demonstrate
accumulation
organs
no
confirmed
long-term
effect
their
release
available.
Standardized
materials
needed
advance
applications
level.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(48)
Опубликована: Июль 18, 2024
Abstract
Two‐photon
excitation
(2PE)
represents
substantial
advantages
in
biophotonics
over
traditional
one‐photon
(1PE),
offering
enhanced
spatial
resolution
and
deeper
tissue
penetration
capabilities.
Since
its
introduction
the
1990s,
two‐photon
excited
microscopy
has
spurred
rapid
emergence
of
novel
2PE‐based
applications,
including
photodynamic
therapy
(PDT)
targeted
release
biologically
active
agents.
This
review
first
elucidates
fundamental
principles
2PE
before
comprehensively
examining
evolution
photosensitizers
(PSs)
for
PDT
(2P‐PDT),
covering
both
nanomaterials
small
molecules,
categorized
based
on
their
respective
characteristics.
Additionally,
it
explores
advancements
PS
development
integrating
2P‐PDT
with
other
therapeutic
modalities
(e.g.,
photothermal
therapy,
chemotherapy,
immunotherapy,
gene
etc.).
Subsequent
sections
provide
an
overview
photoactivatable
compounds
absorption
properties
controlled
various
agents
drugs,
genes,
gasotransmitters),
emphasizing
potential
anticancer
applications.
Last,
a
deep
discussion
deciphers
prospects
challenges
2P‐mediated
cancer
treatment,
particularly
concerning
clinical
translation.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 6, 2025
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
of
characterized
by
the
lack
estrogen
receptor
(ER),
progesterone
(PR),
and
human
epidermal
growth
factor
2
(HER2).
Chemotherapy
remains
primary
treatment
option,
yet
TNBC
frequently
develops
resistance,
leading
to
relapse
metastasis.
Emerging
evidence
highlights
potential
combining
DNA
methylation
inhibitors
with
immune
checkpoint
(ICIs).
contributes
escape
silencing
immune-regulatory
genes,
thereby
reducing
tumor's
visibility
cells.
Reversing
this
epigenetic
modification
can
reinvigorate
surveillance
enhance
efficacy
immunotherapies.
This
review
discusses
role
in
progression
evasion,
focusing
on
recent
advances
combination
therapies
involving
ICIs.
We
discuss
underlying
mechanisms
that
enable
these
therapeutic
synergies,
preclinical
clinical
supporting
approach,
challenges
posed
tumor
heterogeneity,
drug
toxicity.
Finally,
we
explore
for
personalized
strategies
incorporating
multi-omics
data
optimize
outcomes.
The
integration
immunotherapy
offers
a
promising
avenue
improving
survival
patients.
Expert Opinion on Drug Delivery,
Год журнала:
2020,
Номер
18(3), С. 369 - 382
Опубликована: Окт. 13, 2020
Introduction
Nanodiamond
(ND)
refers
to
diamond
particles
with
sizes
from
few
near
100
nanometers.
For
its
superb
physical,
chemical
and
spectroscopic
properties,
it
has
been
proposed
studied
the
aims
for
bio
imaging
drug
delivery.
Many
modalities
on
conjugating
molecules
ND
form
ND-X
more
efficient
delivery
have
demonstrated
in
cellular
animal
models.Area
covered
novel
approaches
utilizing
nanodiamond
as
a
platform
recently.
This
review
summarizes
recent
developments
facilitated
delivery,
complexes
preparations
tests
models.
The
outlook
clinical
translation
is
discussed.Expert
opinion
(ND-X)
produced
different
methods
are
realized
delivery;
almost
all
studies
reported
being
compared
pure
alone.
However,
of
particle
size
less
than
10
nm
found
toxic
due
surface
structure,
strongly
aggregate.
In
vivo
demonstrate
accumulation
organs
no
confirmed
long-term
effect
their
release
available.
Standardized
materials
needed
advance
applications
level.
