Characterising long COVID: a living systematic review

BMJ Global Health, Год журнала: 2021, Номер 6(9), С. e005427 - e005427

Опубликована: Сен. 1, 2021

While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, help inform management, rehabilitation strategies interventional studies improve long-term outcomes.A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Research COVID-19 database, LitCovid Google Scholar were searched till 17 March 2021. Studies including at least 100 people with confirmed or clinically suspected 12 weeks more post onset included. Risk of bias was assessed using the tool produced by Hoy et al. Results analysed descriptive statistics meta-analyses estimate prevalence.A total 39 included: 32 cohort, 6 cross-sectional 1 case-control. Most showed high moderate risk bias. None set in low-income countries few included children. reported 10 951 (48% female) countries. previously hospitalised (78%, 8520/10 951). The longest mean follow-up time 221.7 (SD: 10.9) days onset. Over 60 physical psychological signs symptoms wide prevalence reported, most commonly weakness (41%; 95% CI 25% 59%), general malaise (33%; 15% 57%), fatigue (31%; 24% 39%), concentration impairment (26%; 21% 32%) breathlessness (25%; 18% 34%). 37% (95% 60%) patients reduced quality life; 26% (10/39) presented pulmonary function.Long a complex condition prolonged heterogeneous symptoms. nature precludes precise case definition evaluation. There an urgent need for prospective, robust, standardised, controlled into aetiology, factors biomarkers characterise different at-risk populations settings.CRD42020211131.

Язык: Английский

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Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis

Brain Communications, Год журнала: 2021, Номер 4(1)

Опубликована: Дек. 15, 2021

The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined prevalence survivors COVID-19. For this pre-registered systematic review meta-analysis (PROSPERO ID CRD42021239750), searched MEDLINE, EMBASE, CINAHL PsycINFO to 20 February 2021, plus our own curated database. We included peer-reviewed studies reporting at post-acute or later time-points infection control groups where available. each study, a minimum two authors extracted summary data. symptom, calculated pooled using generalized linear mixed models. Heterogeneity was measured with I2. Subgroup analyses were conducted for hospitalization, severity duration follow-up. From 2844 unique titles, 51 (n = 18 917 patients). mean follow-up 77 days (range 14-182 days). Study quality most commonly moderate. prevalent symptom sleep disturbance [pooled 27.4% (95% confidence interval 21.4-34.4%)], followed by fatigue [24.4% (17.5-32.9%)], objective cognitive impairment [20.2% (10.3-35.7%)], anxiety [19.1% (13.3-26.8%)] post-traumatic stress [15.7% (9.9-24.1%)]. Only reported groups, both higher frequencies versus controls. Between-study heterogeneity high (I2 79.6-98.6%). There little no evidence differential based on hospitalization status, duration. Neuropsychiatric common from literature longer-term consequences is still maturing but indicates particularly insomnia, fatigue, disorders first 6 months infection.

Язык: Английский

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ESCMID rapid guidelines for assessment and management of long COVID

Clinical Microbiology and Infection, Год журнала: 2022, Номер 28(7), С. 955 - 972

Опубликована: Фев. 17, 2022

Язык: Английский

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Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(3), С. 524 - 524

Опубликована: Янв. 20, 2022

Though the acute effects of SARS-CoV-2 infection have been extensively reported, long-term are less well described. Specifically, while clinicians endure to battle COVID-19, we also need develop broad strategies manage post-COVID-19 symptoms and encourage those affected seek suitable care. This review addresses possible involvement lung, heart brain in post-viral syndromes describes suggested management syndrome. Post-COVID-19 respiratory manifestations comprise coughing shortness breath. Furthermore, arrhythmias, palpitations, hypotension, increased rate, venous thromboembolic diseases, myocarditis failure usual cardiovascular events. Among neurological manifestations, headache, peripheral neuropathy symptoms, memory issues, lack concentration sleep disorders most commonly observed with varying frequencies. Finally, mental health issues affecting abilities mood fluctuations, namely anxiety depression, frequently seen. long COVID is a complex syndrome protracted heterogeneous patients who experience sequelae require personalized treatment as ongoing support.

Язык: Английский

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COVID‑19 and post‑traumatic stress disorder: The perfect ‘storm’ for mental health (Review)

Experimental and Therapeutic Medicine, Год журнала: 2021, Номер 22(4)

Опубликована: Авг. 11, 2021

Since its outbreak, in December, 2019, the Chinese city of Wuhan, coronavirus disease 2019 (COVID‑19), caused by severe acute respiratory syndrome 2 (SARS‑CoV‑2) has evolved into an ongoing global pandemic. Due to novel antigenic properties this virus, world population could not develop immunity effectively and led subsequent spread COVID‑19. This unprecedented emergency situation with significant negative effects on health well‑being both individual societal level. Apart from health, economic social consequences, impact pandemic mental is increasingly being reported scientific literature. The present review aimed provide a comprehensive discussion possible neurological neuropsychiatric manifestations SARS‑CoV‑2, together related underlying molecular pathways. In addition, focused populations which are at higher risk developing psychiatric disturbances due COVID‑19 discussed routes clinical management therapeutics minimize burden associated disorders. Moreover, research findings exploring prevalence COVID‑19‑related post‑traumatic stress disorder (PTSD) symptoms across vulnerable groups, including children, adolescents survivors presented, particular emphasis those who required hospitalization and/or intensive care unit admission. Based available literature, identification potential determinants PTSD different underlined. Lessons learnt pandemics globe highlight utmost importance for evidence‑based, proactive targeted interventions high‑risk groups aiming mitigate risks manage vulnerabilities.

Язык: Английский

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Characterising long term Covid-19: a living systematic review

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Дек. 9, 2020

ABSTRACT Background While it is now apparent clinical sequelae (often called Long Covid) may persist after acute Covid-19, their nature, frequency, and aetiology are poorly characterised. This study aims to regularly synthesise evidence on Covid characteristics, inform management, rehabilitation, interventional studies improve long term outcomes. Methods A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Research Database LitCOVID, Google Scholar were searched up 17th March 2021. Published including at least 100 people with confirmed or clinically suspected Covid-19 12 weeks more post-onset included. Results analysed using descriptive statistics meta-analyses estimate prevalence 95% confidence intervals (CIs). Thirty-nine included: 32 cohort, six cross-sectional, one case-control. Most showed high moderate risk of bias. None set in low-income countries, limited included children. Studies reported 10,951 (48% female) countries. followed-up post hospital discharge (78%, 8520/10951). The longest mean follow-up was 221.7 (SD: 10.9) days onset. An extensive range symptoms wide reported, most commonly weakness (41%; CI 25% 59%), malaise (33%; 15% 57%), fatigue (31%; 24% 39%), concentration impairment (26%; 21% 32%), breathlessness (25%; 18% 34%). Other frequent musculoskeletal, neurological, psychological. 37% (95% 60%) reduced quality life. Conclusion a complex condition heterogeneous symptoms. nature the precludes precise case definition evaluation factors. There an urgent need for prospective, robust, standardised controlled into aetiology, factors, biomarkers characterise different at-risk populations settings. Systematic review registration protocol prospectively registered PROSPERO database (CRD42020211131). Section 1: What already known? significant number continue describe ongoing phase often referred as Covid. uncertain prevalence, which there currently no definition. 2: new findings? ‘living’ provides comprehensive summary peer-reviewed published persistent will be updated emerges. breadth suggests complex, affecting both those who hospitalised managed community. Our identifies general interval 32%) 34%) common 3: do findings imply? current base spectrum limited, based heterogenous data, vulnerable biases, hence caution should used when interpreting generalising results. areas where further research critically needed help define its biomarkers, well impact variants concern vaccination

Язык: Английский

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Mental health outcomes of adults hospitalized for COVID-19: A systematic review

Journal of Affective Disorders Reports, Год журнала: 2022, Номер 8, С. 100312 - 100312

Опубликована: Фев. 10, 2022

Patients hospitalized for COVID-19 may be at high risk of mental health (MH) disorders. This systematic review assesses MH outcomes among adults during and after hospitalization ascertains care utilization resource needs.We searched multiple medical literature databases studies published December 2019 to March 2021. Studies ≥ 200 participants were synthesized. One reviewer completed article selection, data abstraction assessed study quality strength evidence, with verification by a second.Fifty articles met preliminary inclusion criteria; 19 that included Evidence from these primarily fair-quality suggests many patients experience symptoms depression (9-66%), anxiety (30-39%), insomnia (24-40%) 3 months COVID-19. However, infrequently receive new disorder diagnosis 6 (5% are diagnosed mood disorder, 7% 3% insomnia). Some - including women those more severe higher poor outcomes. Data on needs currently limited.Most small, did not report the proportion preexisting disorders, use comparison groups.While COVID-19, most do go develop disorder. Future should whether have disorders compare other causes.

Язык: Английский

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Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability

Upsala Journal of Medical Sciences, Год журнала: 2022, Номер 127

Опубликована: Авг. 9, 2022

Better knowledge of long-term symptoms following coronavirus disease 2019 (COVID-19), the so-called post-COVID-19, in non-hospitalized patients is needed. The aim this study was to persisent up 12 months after COVID-19 and their impact on work ability. We also investigated predictors persistent symptoms.This encompassed adult subjects with a infection confirmed via positive nasopharyngeal swab polymerase chain reaction test during first wave pandemic Uppsala, Sweden. In total, 566 were sent survey e-mail or post an invitation participate post-diagnosis. majority healthcare workers, as group prioritized for testing.A total 366 responded, 47% reporting diagnosis. most commonly reported at time impaired sense smell and/or taste fatigue. Among being born abroad, lower physical fitness compared peers before COVID-19, body mass index >25 kg/m2, cooccurrence hypertension chronic pain, having more than seven general onset. Respondents self-reported negatively about health ability.This indicated that many people who had mild might have variety symptoms. It highlights importance considering ability COVID-19.

Язык: Английский

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“Like before, but not exactly”: the Qualy-REACT qualitative inquiry into the lived experience of long COVID

BMC Public Health, Год журнала: 2022, Номер 22(1)

Опубликована: Март 28, 2022

Post-acute sequelae of SARS-CoV-2 infection (PASC) affect millions individuals worldwide. Rehabilitation interventions could support during the recovery phase COVID-19, but a comprehensive understanding this new disease and its associated needs is crucial. This qualitative study investigated experience who had been hospitalized for focusing on those difficulties they perceived as most urgent.This naturalistic was part single-center mix-method cross-sectional (REACT) conducted in Italy first peak pandemic. The data collection took place through telephone interview 3 months after hospital discharge. discharged hospitalization COVID-19 main research question - "Tell me, how has it going since you were discharged?". Two secondary questions symptoms, activities, participation. Data recorded transcribed verbatim within 48 h. An empirical phenomenological approach used by researchers, independently analyzed and, consensus, developed an interpretative model to answer question. Translation occurred analyzed.During pandemic, 784 with from hospitals Local Health Authority Province Reggio Emilia (Italy); 446 excluded due presence acute or chronic conditions causing disability other than (n. 339), inability participate procedures 56), insufficient medical documentation allow screening 21), discharge residential facilities 25), pregnancy 5). Overall, 150 consented REACT study, 56 (60.7% male, average age 62.8 years ±11.8) interviewed June-July 2020, up saturation. Persistent feelings isolation, fear stigma, emotional distress, fatalistic attitude, return (adapted) life course key themes that characterized participants' discharge.The narrated participants confirms persistence symptoms described PASC highlights sense isolation psychological distress. These phenomena may trigger vicious circle, also reported adaptation processes allowed them gradually their course. Whether all are able rapidly activate these mechanisms whether rehabilitation can help break circle improving residual remain be seen.ClinicalTrials.com NCT04438239.

Язык: Английский

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Prolonged Gastrointestinal Manifestations After Recovery From COVID-19

Clinical Gastroenterology and Hepatology, Год журнала: 2023, Номер 22(5), С. 1098 - 1107.e3

Опубликована: Ноя. 22, 2023

Язык: Английский

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