Post-acute sequelae of covid-19 six to 12 months after infection: population based study

BMJ, Год журнала: 2022, Номер unknown, С. e071050 - e071050

Опубликована: Окт. 13, 2022

Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, risk factors, examine the association with general health working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years confirmed SARS-CoV-2 infection between October 2020 March 2021 notified authorities in four geographically defined regions southern Germany. Participants 50 457 patients were invited participate study, whom 053 (24%) responded 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted covid-19; follow-up time 8.5 months) could be included analyses. Main outcome measures Symptom frequencies (six versus before infection), severity clustering, associations recovery Results The fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% 38.1%) neurocognitive impairment (31.3% (3561/11 361), 30.5% 32.2%) contributed most reduced capacity, but chest symptoms, anxiety/depression, headache/dizziness, pain syndromes also prevalent relevant for some differences according sex age. Considering new at least moderate daily life ≤80% recovered or overall estimate was 28.5% (3289/11 536, 27.7% 29.3%) among participants 6.5% (3289/50 457) infected adult population (assuming that all non-responders had completely recovered). true value is likely these estimates. Conclusions Despite limitation a low response rate possible selection recall biases, this suggests considerable burden self-reported post-acute sequelae, notably impairment, even young middle adults mild substantial impact on Trial registration German registry clinical studies DRKS 00027012.

Язык: Английский

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COVID-19 2022 update: transition of the pandemic to the endemic phase

Human Genomics, Год журнала: 2022, Номер 16(1)

Опубликована: Июнь 1, 2022

Abstract COVID-19, which is caused by the SARS-CoV-2, has ravaged world for past 2 years. Here, we review current state of research into disease with focus on its history, human genetics and genomics transition from pandemic to endemic phase. We are particularly concerned lack solid information initial phases that highlighted necessity better preparation face similar future threats. On other hand, gratified progress genetic susceptibility investigations believe now time explore The latter will require worldwide vigilance cooperation, especially in emerging countries. In phase, vaccination rates have lagged developed countries should assist, as warranted, bolstering worldwide. also discuss status vaccines outlook COVID-19.

Язык: Английский

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Long Covid: where we stand and challenges ahead

Cell Death and Differentiation, Год журнала: 2022, Номер unknown

Опубликована: Сен. 7, 2022

Abstract Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially Long Covid, has been defined a constellation signs symptoms which persist for weeks or months after the initial infection. PASC affects wide range diverse organs systems, with manifestations involving lungs, brain, cardiovascular system other such kidney neuromuscular system. The pathogenesis is complex multifactorial. Evidence suggests that seeding persistence in different organs, reactivation, response to unrelated viruses EBV, autoimmunity, uncontrolled inflammation are major drivers PASC. relative importance pathogenetic pathways may differ tissue organ contexts. vaccination, addition protecting against disease, reduces breakthrough infection although its actual impact remains be defined. represents formidable challenge health care systems dissecting mechanisms pave way targeted preventive therapeutic approaches.

Язык: Английский

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Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

EClinicalMedicine, Год журнала: 2023, Номер 62, С. 102107 - 102107

Опубликована: Июль 21, 2023

Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL). Outcome interest identification protective PCS by phenotype, setting, severity disease, treatment, vaccination status. We used SF-36 questionnaire assess evolution QoL index during follow-up unsupervised machine learning algorithms (principal component analysis, PCA) explore symptom clusters. Severity defined phenotype QoL. also generalized linear models analyse the impact on associated factors. CT registration number: NCT05097677.Among 1796 patients enrolled, 1030 (57%) suffered least one 12-month. PCA identified 4 phenotypes: chronic fatigue-like (CFs: fatigue, headache memory loss, 757 patients, 42%), respiratory (REs: cough dyspnoea, 502, 23%); pain (CPs: arthralgia myalgia, 399, 22%); neurosensorial (NSs: alteration taste smell, 197, 11%). Determinants phenotypes were different (all comparisons p < 0.05): being female increased CPs, NSs, CFs; pulmonary diseases REs; neurological symptoms diagnosis REs, oxygen therapy CFs gastrointestinal CFs. Early treatment infection monoclonal Ab phenotypes), corticosteroids for mild/severe cases (NSs), (CPs) less likely be 0.05). Highest reduction detected REs CPs (43.57 43.86 vs 57.32 PCS-negative controls, 0.001). Female sex (p 0.001), = 0.034) renal complications 0.002) acute increase severe (QoL <50). Vaccination early reduced 0.01 0.03, respectively).Our provides evidence suggesting that can classified QoL, underlying possible pathogenic mechanisms. each PCS. These results might help designing pathogenesis studies selecting high-risk inclusion therapeutic management trials.The received funding Horizon ORCHESTRA project, grant 101016167; Netherlands Organisation Health Research Development (ZonMw), 10430012010023; Inserm, REACTing (REsearch & ACtion emergING infectious diseases) consortium French Ministry Health, PHRC 20-0424.

Язык: Английский

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Possible Pathogenesis and Prevention of Long COVID: SARS-CoV-2-Induced Mitochondrial Disorder

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 8034 - 8034

Опубликована: Апрель 28, 2023

Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities. The present lack of effective treatments makes managing long COVID a major challenge. One the underlying mechanisms be mitochondrial dysfunction. Severe acute respiratory syndrome 2 (SARS-CoV-2) infections can alter mitochondria responsible for energy production in cells. This alteration leads to dysfunction which, turn, increases oxidative stress. Ultimately, this results loss integrity and cell death. Moreover, viral proteins bind complexes, disrupting function causing immune cells over-react. over-reaction inflammation potentially symptoms. It is important note that roles damage inflammatory responses caused by SARS-CoV-2 development are still being elucidated. Targeting provide promising new clinical approaches long-COVID patients; however, further studies needed evaluate safety efficacy such approaches.

Язык: Английский

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Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment

Viruses, Год журнала: 2023, Номер 15(2), С. 389 - 389

Опубликована: Янв. 29, 2023

An increase in post-COVID patients with late sequelae of acute COVID-19 infection is emerging as an ongoing challenge for physicians and healthcare professionals. Since the beginning pandemic, it has rapidly become evident that not limited to respiratory tract but several organs, including cardiovascular system, can be affected. Moreover, a significant proportion (ranging from about 10 up 50%) former COVID-19, cardiopulmonary symptoms such dyspnea, palpitations, restricted physical capacity, cardiac arrhythmias persist weeks months after SARS-CoV-2 infection. The spectrum COVID-19-associated rather wide, most likely due various pathomechanisms. In this article, prevalence underlying pathologies are reviewed, direct myocardial injury abnormal consequences impact on electric instability. hyperinflammatory reaction host immune system specifically considered. distinct rhythm disorders occurring discussed regard their clinical management.

Язык: Английский

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Risk factors identification of COVID‐19 patients with chronic obstructive pulmonary disease: A retrospective study in Punjab‐Pakistan

Immunity Inflammation and Disease, Год журнала: 2023, Номер 11(8)

Опубликована: Авг. 1, 2023

Abstract Background Accessibility to the immense collection of studies on noncommunicable diseases related coronavirus disease 2019 (COVID‐19) and severe acute respiratory syndrome 2 (SARS‐CoV‐2) is an immediate focus researchers. However, there a scarcity information about chronic obstructed pulmonary (COPD), which associated with high rate infection in COVID‐19 patients. Moreover, by combining effects SARS‐CoV‐2 COPD patients, we may be able overcome formidable obstacles factors, diagnosis influencers. Materials Methods A retrospective study 280 patients was conducted at DHQ Hospital Muzaffargarh Punjab, Pakistan. Negative binomial regression describes risk fixed successive variables. The association described Cox proportional hazard model coefficient determined through log‐likelihood observation. Patients had their survival mortality plotted Kaplan–Meier curves. Results increased death due variables such as cough, lower tract (LRTI), tuberculosis (TB), body‐aches being 1.369, 0.693, 0.170, 0.217 times higher (95% confidence interval [CI]: 0.747–1.992), CI: 0.231–1.156), 0.008–0.332), −0.07 0.440) while it decreased 0.396 normal condition. Conclusion We found that symptoms (cough, LRTI, TB, bodyaches) are statistically significant who were most infected SARS‐CoV‐2.

Язык: Английский

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Risk of Cardiovascular Disease After COVID‐19 Diagnosis Among Adults With and Without Diabetes

Journal of the American Heart Association, Год журнала: 2023, Номер 12(13)

Опубликована: Июнь 29, 2023

Background Growing evidence suggests incident cardiovascular disease (CVD) may be a long-term outcome of COVID-19 infection, and chronic diseases, such as diabetes, influence CVD risk associated with COVID-19. We evaluated the postacute >30 days after diagnosis by diabetes status. Methods Results included adults ≥20 years old from March 1, 2020 through December 31, 2021 in retrospective cohort study IQVIA PharMetrics Plus insurance claims database. A contemporaneous control group comprised without recorded diagnoses for or other acute respiratory infections. Two historical groups patients an infection. Cardiovascular outcomes cerebrovascular disorders, dysrhythmia, inflammatory heart disease, ischemic thrombotic cardiac major adverse events, any CVD. The total sample 23 824 095 (mean age, 48.4 [SD, 15.7 years]; 51.9% women; mean follow-up, 8.5 months 5.8 months]). In multivariable Cox regression models, had significantly greater all compared (hazard ratio [HR], 1.66 [1.62-1.71], diabetes; HR, 1.75 [1.73-1.78], diabetes). Risk was attenuated but still significant majority when comparing to both groups. Conclusions is higher than among controls COVID-19, regardless Therefore, monitoring essential beyond first 30 diagnosis.

Язык: Английский

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A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

Pathogens, Год журнала: 2022, Номер 11(3), С. 368 - 368

Опубликована: Март 17, 2022

Development and deployment of biosensors for the rapid detection 2019 novel severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are utmost importance urgency during this recent outbreak coronavirus pneumonia (COVID-19) caused by SARS-CoV-2 infection, which spread rapidly around world. Cases now confirmed in February 2022 indicate that more than 170 countries worldwide affected. Recent evidence indicates over 430 million cases with 5.92 deaths scattered across globe, United States having 78 920,000 deaths. The US has many China where were first reported late December 2019. During initial China, leaders did not anticipate it could reach whole world, spreading to posing threats global health. objective review is summarize origin COVID-19, its biological nature, comparison other coronaviruses, symptoms, prevention, treatment, potential, available methods detection, post-COVID-19 symptoms.

Язык: Английский

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Vaccination status and long COVID symptoms in patients discharged from hospital

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Фев. 11, 2023

Abstract Effective vaccination against coronavirus mitigates the risk of hospitalisation and mortality; however, it is unclear whether status influences long COVID symptoms in patients who require hospitalisation. The available evidence limited to outpatients with mild disease. Here, we evaluated 412 (age: 60 ± 16 years, 65% males) consecutively admitted two Hospitals Brazil due confirmed disease 2019 (COVID-19). Compared complete (n = 185) before infection or hospitalisation, those no incomplete 227) were younger had a lower frequency several comorbidities. Data during revealed that group required more admissions intensive care unit (ICU), used corticosteroids, higher rates pulmonary embolism deep venous thrombosis than group. Ninety days after hospital discharge, presented (≥ 1) (40 vs. 27%; p 0.013). After adjusting for confounders, (odds ratio [OR] 1.819; 95% confidence interval [CI] 1.175–2.815), female sex (OR 2.435; CI 1.575–3.764) ICU admission 1.697; 1.062–2.712) independently associated ≥ 1 symptom 90 discharge. In conclusion, even severe COVID-19, probability symptoms.

Язык: Английский

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