The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring

Developmental Neuroscience, Год журнала: 2023, Номер 45(4), С. 191 - 209

Опубликована: Янв. 1, 2023

Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors, including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA has been consistently recognized as major risk factor for neurodevelopmental this association seems to be especially important viral infections exposure during pregnancy was associated with higher developing such schizophrenia. In MIA, the gestational parent’s response an stimulus alters or interrupts fetal development, triggering consequences. As occur in any pregnancy, it is understand many factors at play that contribute altered brain development offspring, considering recent global events COVID-19 pandemic. The underlying mechanisms by which results deleterious outcomes are not yet clear, but due initiates, becoming apparent microglia critically involved. Through investigation animal models, role field more evident. Compelling evidence models indicates disrupt synaptic pruning, neuronal progenitor cell proliferation/differentiation, oligodendrogenesis, more. Microglia appear active player, assisting these neural-related functions healthy also mediating MIA-induced disturbances critical processes when neurodevelopment challenged. present review illustrates complex web reviewing literature, focusing on resulting mimetic polyinosinic-polycytidylic acid rodents, provide clear description how impacts microglial what means offspring’s neurodevelopment. Moreover, we discuss possible implications pandemic current next generations frame propose some putative pharmacological non-pharmacological approaches prevent attenuate

Язык: Английский

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Psychological distress among healthcare students in Poland from COVID-19 to war on Ukraine: a cross-sectional exploratory study

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Июнь 19, 2023

Objectives Healthcare students went through a rough time in March 2022 due to extreme changes the educational system (moving from online stationary learning) and Ukrainian-Russian war circumstances. Our study aims update knowledge about psychological distress its impact on healthcare Poland after two years of COVID-19 pandemic, followed by intense political instability Europe. Methods We conducted cross-sectional Poznan University Medical Sciences, Poland, April 2022. The questionnaire included subjective retrospective 5-point Likert-scales ratings anxiety, stress, depression self-reported information various predictors. Results anxiety levels at beginning pandemic were higher than There was no significant reduction stress depression. Females had initial post-pandemic levels. Higher reported significantly correlated with Eastern Europe (Spearman r = 0.178, 0.169, 0.154, p ≤ 0.001, respectively). concern moving towards education showed association only level (r 0.099, 0.034). also observed positive correlation between deteriorating sleep quality ,=0.325, 0.410, 0.440, < 0.001), feeling worsening relationships family peers 0.325, 0.343, 0.379, sense loss efficient management 0.321, 0.345, 0.001). Conclusion Throughout progression Ukrainian females improved (lower levels) anxiety. Nevertheless, current remain alarming, while remained unchanged. Mental, psychological, social support activities are required for students, especially those away their families. Time management, academic performance, coping skills relation additional stressors global require further research this group students.

Язык: Английский

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Adaptive and maladaptive profiles in mothers of infants – a cross-sectional study on the meaning of self-confidence and mental health

Midwifery, Год журнала: 2025, Номер 143, С. 104320 - 104320

Опубликована: Янв. 30, 2025

Язык: Английский

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The COVID-19 Pandemic and Levels of Physical Activity in the Last Trimester, Life Satisfaction and Perceived Stress in Late Pregnancy and in the Early Puerperium

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(5), С. 3066 - 3066

Опубликована: Март 5, 2022

Background: The aim of this study was to determine the impact COVID-19 pandemic on levels physical activity during third trimester pregnancy, life satisfaction and stress in women late pregnancy early postpartum. Methods: conducted among 740 patients maternity wards Cracow hospitals days 1–8 Patients who were surveyed before (December 2019–March 2020) included prepandemic group (PPan: n = 252). second (COVID 1 group, Cov1: 262) examined stages (May–September 2020). In turn, participants population vaccination campaign (June–September 2021) qualified COVID 2 (Cov2: 226). research tools used original questionnaire addition standardized questionnaires assessing last (the Pregnancy Physical Activity Questionnaire); previous Satisfaction with Life Scale); month Perceived Stress Scale). Results: During pandemic, reduced level energy spent total activity; nevertheless, statistically significant differences found only between PPan Cov2 groups (p 0.001). At significantly mobility activities (Cov1 vs. PPan: p < 0.001; Cov1 Cov2: 0.007), while they less household (Cov2 0.002, 0.002). There no satisfaction. Conclusions: impacted however, it did not change perceived late-stage puerperium.

Язык: Английский

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Maternal Exposure to Stress During Covid-19 and Non-Syndromic Orofacial Clefts: A Cohort Retrospective Study

The Cleft Palate-Craniofacial Journal, Год журнала: 2024, Номер unknown

Опубликована: Янв. 18, 2024

Objective The coronavirus (COVID-19) pandemic presents an opportunity to study stress's effect on the development of non-syndromic orofacial clefts (NSOFCs). This was aimed at assessing maternal stress exposure during pregestational first trimester pregnancy periods and NSOFCs a year COVID-19 pandemic. Design Cohort infants with controls matched based recruitment site age. Setting Government hospitals in Saudi Arabia between November 2020 2021. Main Outcome Measures Data collection included NSOFC clinical examination assessment using Modified Life Events Questionnaire, Fear Scale, focus lack planning threatened miscarriage. Results Of 557 recruited, 191 had NSOFCs. Logistic regression analysis adjusted odds ratios (AORs) that removed effects confounders showed any seven stressful life events (AOR:3.78, P < .001) family histories relatives (AOR:9.73, increased AOR for development. In contrast, folic acid (AOR:0.56, P.010), miscarriage (AOR:0.17, = .001), fear (AOR:0.83, .038), suspected infection (AOR:0.43, .008) decreased Conclusion Along established risk associated history birth defects, may be factor Beyond acid's known benefit, it higher health concerns contribute protective behaviors pregnancy. Ongoing research is needed specify factors NSOFC.

Язык: Английский

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A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial

JMIR Research Protocols, Год журнала: 2023, Номер 12, С. e41751 - e41751

Опубликована: Фев. 7, 2023

Perinatal mood disorders such as depression and anxiety are common, with subclinical symptomology manifesting perinatal disturbances being even more prevalent. These could potentially affect breastfeeding practices infant development. Pregnant lactating women usually limit their exposure to medications, including those for psychological symptoms. Interestingly, the naturally occurring probiotic Bifidobacterium longum (BL) NCC3001 has been shown reduce anxious behavior in preclinical models feelings of low nonpregnant human adults. During COVID-19 pandemic, mental health issues increased, conventionally conducted clinical trials were restricted by social distancing regulations.

Язык: Английский

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Adverse Mental Health Sequelae of COVID-19 Pandemic in the Pregnant Population and Useful Implications for Clinical Practice

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(8), С. 2072 - 2072

Опубликована: Апрель 7, 2022

The COVID-19 pandemic has increased risk of disturbances in the functioning everyday life, directly or indirectly influenced mental disorders most vulnerable populations, including pregnant women. aim this study was to analyze adverse health effects population during pandemic, investigate factors for outcomes, identify protective factors, and create practical implications clinical practice, bearing mind need improve perinatal healthcare such pandemics. Qualitative research conducted electronic databases PubMed Web Sciences keywords COVID-19, pregnancy, depression, anxiety, telemedicine relevant critical articles (n = 3280) published from 2020 until October 2021, outlining outcomes control studies, meta-analysis, cross-sectional face-to-face evaluation survey remotely administered observational studies regarding main topic; all were evaluated. Mental problems among women linked cases, show symptoms insomnia, PTSD may cause pregnancy fetus newborn development, even at later stages life. Therefore, useful practice improving associated with are highly desirable. Our findings support advocate modify scope provider event a disaster, be implemented adopted by providers as practice.

Язык: Английский

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Psychometric properties of the Greek versions of the Pandemic-Related Pregnancy Stress Scale and the Pandemic-Related Postpartum Stress Scale and associated risk factors during the second year of the COVID-19 pandemic

BJPsych Open, Год журнала: 2023, Номер 9(2)

Опубликована: Фев. 1, 2023

Background The COVID-19 pandemic has affected perinatal mental health. Reliable tools are needed to assess stress during situations. Aims To the psychometric properties of Greek versions Pandemic-Related Pregnancy Stress Scale (PREPS) and Postpartum (PREPS-PP) explore associations between women's characteristics second wave. Methods PREPS PREPS-PP were completed by 264 pregnant 188 postpartum women, respectively, who also State-Trait Anxiety Inventory (STAI) Edinburgh Perinatal Depression (EPDS). Results internal consistency was similar for PREPS-PP. It good preparedness (a = 0.77 α 0.71, respectively) infection (α 0.83 both scales) but low positive appraisal 0.46 0.41, respectively). Of 55.33% 55.27%, reported scores ≥40 on STAI-S STAI-T, respective percentages women 47.34% 46.80%. In addition, 14.39% 20.74% scored ≥13 EPDS. Higher associated with primiparity ( P 0.022 0.021, disrupted care 0.069 0.007, higher chronic disease 0.037), 0.02) perceived risk 0.065). score in groups 0.107 0.010, Conclusions valid assessment at a health crisis.

Язык: Английский

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Impact of the COVID-19 pandemic on depression during pregnancy: a cross-sectional study

Korean journal of women health nursing/Yeoseong geon'gang ganho hag'hoeji/Yeoseong geon-gang ganho hakoeji, Год журнала: 2023, Номер 29(1), С. 44 - 54

Опубликована: Март 31, 2023

Uncertainty and restrictions on daily life have increased fear, stress, depression during the coronavirus disease 2019 (COVID-19) pandemic. Depression is most common mental health problem in pregnant women. The purpose of this study was to evaluate levels fear stress related COVID-19 experienced by women, as well their depression, examine factors associated with pregnancy. This a cross-sectional, correlational conducted among 153 women who visited maternity hospital Busan, South Korea. A self-reported questionnaire used for data collection from December 18, 2021 March 8, 2022. Data were analyzed using descriptive statistics, independent t-test, one-way analysis variance, Pearson correlation coefficients, multiple regression. Pregnant moderate level COVID-19, an average score 21.55±4.90. pregnancy 14.86±11.10, 50.3% participants experiencing (≥13). contact confirmed case being third trimester pregnancy, high due difficulties social distancing measures, unintended These five statistically significant explained 35.0% variance Considering prevalence pandemic, it necessary develop interventions reduce anxiety providing correct information alleviating distancing.

Язык: Английский

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Perceived stress and life satisfaction in pregnant women during the COVID-19 pandemic: the mediating role of fear of childbirth and self-esteem

Health Psychology Report, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 23, 2023

Background The COVID-19 pandemic adversely affected the functioning and well-being of pregnant women. Negative feelings during pregnancy difficult situation may be reason behind perceived fear childbirth, which can nega-tively affect women’s life satisfaction. On other hand, some protective factors, such as self-esteem, might mediate relationship between stress in Participants procedure Our study aimed to determine stress, self-esteem A total 262 Polish women participated this study. Perceived Stress Scale (PSS-10), Fear Childbirth (KLP II), Self-Esteem (SES) Satisfaction with Life (SWLS) were used Results results showed that childbirth acted significant predictors satisfaction tested group Additionally, played a mediational role Conclusions According Diener’s concept, is an important component one’s subjective health. There-fore, it analyse factors impact on present suggest preparation for should provided appro-priate psychological care. Support from medical specialists, well relatives, reduce level fears strengthen personal resources. Based results, we conclude not underestimated, they are their

Язык: Английский

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