Mitochondria: It is all about energy

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Язык: Английский

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Investigating the Role of Personalized Nutritional Counseling in Enhancing Oral Health Management: A Cross-Sectional Survey among Saudi Arabian Dental Practitioners

European Journal of General Dentistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Objectives This study evaluated Saudi Arabian dental practitioners' knowledge, practices, and perceptions regarding personalized nutritional counseling (PNC) its integration into oral health management. Materials Methods A total of 207 practitioners in Arabia were the subjects a cross-sectional survey. The survey consisted four sections: (1) knowledge practices PNC, (2) training resources, (3) challenges barriers, (4) impact PNC on data stratified by age, gender, years experience, specialization, workplace setting. Statistical Analysis Descriptive statistics used to analyze frequency responses, chi-square tests performed assess associations between demographic variables (e.g., experience) critical outcomes. significance level p <0.05 was considered statistically significant. Results Out practitioners, most (80%) respondents acknowledged importance nutrition health, yet only 20% regularly provided counseling. Gender showed significant association, with females more likely consider dietary habits (72%, = 0.003) medical history (85%, 0.005) during Notably, confidence levels increased those than 10 experience being significantly confident (p < 0.001). Private clinic professionals also offer guidance (36.4%) compared government (3.8%) teaching institutions (30.3%; Common barriers identified included insufficient (65%, 0.024) time constraints (45%, 0.062). Moreover, perceived management significant, 70% participants agreeing that it enhances overall patient Conclusion findings suggest while recognize value impede consistent application. Addressing these through enhanced resources is essential for integrating routine care ultimately benefiting There strong call improved equip provide advice.

Язык: Английский

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Association between lipid accumulation product (LAP) index and self-reported oral health outcomes: a cross-sectional study

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 4, 2025

Lipid Accumulation Product (LAP) is a biomarker associated with excessive lipid accumulation and various metabolic diseases. Despite the well-established link between oral systemic health, association LAP health remains largely unexplored. Data from 7,124 participants aged over 18 years National Health Nutrition Examination Survey (NHANES) 2009 2014 were analyzed. Multivariate logistic regression models applied to evaluate independent self-reported outcomes, adjusting for potential confounders. There was significant correlation increasing levels deteriorating status (β = 0.26, 95% CI: 0.20 0.32, P < 0.0001). Subgroup analyses revealed that negative outcomes more pronounced in younger individuals those higher education levels. A non-linear relationship identified, significantly as increased up threshold of 83, after which became non-significant. This study demonstrates robust suggesting could be reliable indicator assessing status. The findings highlight importance targeted interventions populations indices prevent deterioration issues.

Язык: Английский

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The effect of Ramadan intermittent fasting on anthropometric, hormonal, metabolic, inflammatory, and oxidative stress markers in pre-and post-menopausal women: a prospective cohort of Saudi women

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Дек. 4, 2024

The menopausal transition significantly affects cardiometabolic health, primarily due to changes in reproductive hormones, particularly decreased estrogen levels and relative androgen excess. Adult Muslim women, both pre-and post-menopausal, are mandated observe Ramadan intermittent fasting (RIF) every year. Therefore, the current study was designed investigate RIF's effects on pre-menopausal (PRE-M) post-menopausal (POST-M) healthy women's health markers. This further evaluated relationship between tested markers participant's basic variables, such as BMI body fatness. Due differences physiological metabolic biomarkers groups, RIF is likely impact PRE-M POST-M women differently.

Язык: Английский

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Nationwide exploration: assessing oral microbiome knowledge among dental professionals in Saudi Arabia and its implications for oral health care

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 31, 2024

The relationship between the microbiome and oral health is intricate, yet there a lack of comprehensive knowledge regarding microbiome's impact on health. Integrating its significance in systemic diseases holds profound implications for dental professionals patient care professional development. This study assessed professionals' comprehension levels Saudi Arabia healthcare. Data were gathered using cross-sectional design by administering online questionnaire to 253 from diverse demographic backgrounds. questionnaire, administered English, was divided into four sections: (1) Microbiome awareness understanding, (2) Diet, nutrition, relationship, (3) diseases, (4) Counselling, education, implications. Statistical analyses used identify understand underlying patterns, including descriptive statistics, chi-squared tests, ANOVA, post hoc tests. Spearman rank correlation coefficient applied assess self-rated knowledge. Of participants, 94.6% familiar with term "microbiome." Merely 13% participants considered be second most diverse, following gut microbiome. About 39.9% knew connection mucosal Furthermore, only 6.7% thought Participant questions averaged 9.19 out 13, 83.7% scoring "good". There significant differences scores among specializations (F = 7.082, P < 0.001) years experience 4.755, 0.003). Significantly, 53.8% had uncertain self-perceptions their microbiome, while 0.8% rated understanding as 'very good'. Our findings reveal that have varying Despite widespread awareness, diversity remains limited. It essential address these gaps through future research educational interventions, considering vital part play promoting personalised dietary recommendations, lifestyle changes, hygiene practices. These initiatives may promote robust microbial community, enhance outcomes, advance healthcare locally globally.

Язык: Английский

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Exploring the Interplay: Oral–Gut Microbiome Connection and the Impact of Diet and Nutrition

European Journal of General Dentistry, Год журнала: 2024, Номер 13(03), С. 165 - 176

Опубликована: Сен. 1, 2024

Abstract The intricate interplay between the oral and intestinal microbiota holds increasing fascination within context of health nutrition. Serving as gateway to gastrointestinal tract, hosts a diverse array microbial species that significantly influence well-being or contribute various diseases. Dysbiosis in has been linked conditions such dental caries, periodontal diseases, systemic disorders, including diabetes, cardiovascular disease, obesity, rheumatoid arthritis, Alzheimer's colorectal cancer. This review aims comprehend nuanced relationship microbiotas, exploring pivotal role diet developing strategies for wellness promotion disease prevention. Drawing insights from myriad studies encompassing both animals humans, we examine implications dysbiosis its impact on health. A bibliographic search 78 scientific articles was conducted across PubMed Central, Web Science, Scopus, Google Scholar, Saudi digital library January 2000 August 2023. Following rigorous screening process, full texts selected were critically reviewed extract relevant information. Articles not meeting inclusion criteria—specifically focused oral–intestinal interaction nutrition—were meticulously excluded. Diet emerges key player influencing microbiotas. Various dietary components, fiber, prebiotics, probiotics, bioactive compounds, have demonstrated significant effects diversity function microorganisms these ecosystems. Conversely, diets high processed foods, added sugars, saturated fats correlate with an elevated risk Understanding intricacies this is paramount development innovative approaches fostering balanced oral–gut axis improving overall human extend preventive therapeutic interventions, emphasizing practical importance unraveling complexities public clinical practice. comprehensive delves into gut microbiota, shedding light their roles particularly focusing Key findings are summarized, future research practice discussed. In conclusion, underscores urgent need special attention targeted interventions promoting

Язык: Английский

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The impact of intermittent fasting on oral health

BDJ, Год журнала: 2024, Номер 236(6), С. 425 - 425

Опубликована: Март 22, 2024

Язык: Английский

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Intermittent fasting: Effectiveness and safety. A review

Terapevticheskii arkhiv, Год журнала: 2024, Номер 96(10), С. 984 - 991

Опубликована: Дек. 9, 2024

The question of effective ways to treat obesity in people different ages inevitably affects nutritional principles. Currently, intermittent fasting is particular interest. There are several variants fasting, the common feature which periodic temporary breaks food intake. This review assessed results studies on effectiveness such a restrictive diet patients with various pathologies.

Язык: Английский

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Exploring the Knowledge of Oral Health and Nutrition Among Saudi Arabian Dental Professionals: A Nationwide Survey

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Background: The association between diet and oral health is complex, yet understanding the influence of nutrition on among dental professionals limited. This study aimed to assess knowledge levels in Saudi Arabia regarding relationship health. Methods: A cross-sectional survey was conducted 211 using an 18-item questionnaire. Statistical Analysis SPSS v23.0 used for analysis. Yes = 1; No/I don't know 0 a score (0–18). mean, SD, proportions were calculated. Kolmogorov–Smirnov test determined normality. Chi-squared post-hoc Tukey analysis assessed relationships. Results: findings revealed that female practitioners (mean 13.41, SD 2.85) older had higher levels, with total mean 12.33 (SD 2.93). Significant correlations observed scores age (ANOVA: F 2.874; p 0.024) gender (t-test: t 6.68, < 0.001). Oral Medicine Specialists Periodontists highest scores, 13.43 2.87) 13.63 2.66), respectively, while General Dentists scored lower 10.49, 3.12; ANOVA: 4.462; Practitioners less than five years experience significantly 11.14, 3.23) compared those 5–10 13.40, 2.34) over 20 12.69, 2.22) 5.016; 0.002). Conclusion: Our reveal have varying While awareness exists, there are gaps nutritional factors influencing outcomes. Addressing these through targeted educational interventions essential, given crucial role play promoting educating patients importance nutrition. Enhancing this will improve patient care contribute better community outcomes informed preventive strategies public initiatives.

Язык: Английский

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Exploring the knowledge of oral health and nutrition among Saudi Arabian dental professionals: a nationwide survey

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 23, 2024

The association between diet and oral health is complex, yet understanding the influence of nutrition on among dental professionals limited. This study aimed to assess knowledge levels in Saudi Arabia regarding relationship health. A cross-sectional survey was conducted 211 using an 18-item questionnaire. Data analysis performed SPSS v23.0. Descriptive statistics were used calculate mean, standard deviation (SD), proportions. Kolmogorov–Smirnov test assessed data normality, while Chi-squared post-hoc Tukey applied evaluate associations variables. findings revealed that female practitioners (mean = 13.41, SD 2.85) older had higher levels, with a total mean score 12.33 (SD 2.93). Significant correlations observed scores age (ANOVA: F 2.874; p 0.024) gender (t-test: t 6.68, < 0.001). Oral Medicine Specialists Periodontists highest scores, 13.43 2.87) 13.63 2.66), respectively, General Dentists scored lower 10.49, 3.12; ANOVA: 4.462; Practitioners less than five years experience significantly 11.14, 3.23) compared those 5–10 13.40, 2.34) over 20 12.69, 2.22) 5.016; 0.002). Our reveal have varying While awareness exists, there are gaps nutritional factors influencing outcomes. Addressing these through targeted educational interventions essential, given crucial role play promoting educating patients importance nutrition. Enhancing this will improve patient care contribute better community outcomes informed preventive strategies public initiatives.

Язык: Английский

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