Immune system, Год журнала: 2024, Номер unknown, С. 293 - 322
Опубликована: Ноя. 8, 2024
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2024, Номер 20(1), С. 58 - 67
Опубликована: Март 3, 2024
Post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS) frequently coexist share neurobiological clinical features. In particular, the results of meta-analyses indicate a higher prevalence MetS in patients with PTSD compared to general population. is also recognized risk factor for MetS. This synchronicity can be partially explained by pathogenetic pathways present both conditions. These include genetic factors, dysfunction hypothalamic-pituitary-adrenal axis, chronic low-grade inflammation, oxidative stress, insulin resistance, immune dysregulation. Thus, similar mechanisms are involved worsening development adverse cardiovascular events associated Dyssomnias one characteristic features PTSD. Today, it believed that posttraumatic circadian rhythm disorders core not secondary feature PTSD, which mediate correlates due homeostasis imbalance. At same time, dyssomnias, chronodestruction, depressive part pathogenesis obesity, treatment dyssomnias key tasks prevention comorbid Regulation sleep processes rhythms through exogenous intervention, especially melatonergic drugs, likely preventing treating people who have The purpose this review analyze specifics relationships between MetS, disorders. We conducted search Scopus, Science Direct (from Elsevier), PubMed, including Medline databases. words used were “post-traumatic disorder,” “dyssomnias,” “chronodestruction,” “metabolic syndrome”. identification research findings found during online searches manual searching bibliography publications.
Язык: Английский
Процитировано
7
World Neurosurgery, Год журнала: 2024, Номер 188, С. 136 - 149
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
5
Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118425 - 118425
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
5
Psychoneuroendocrinology, Год журнала: 2025, Номер 175, С. 107406 - 107406
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Archives of Women s Mental Health, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0
Eastern Ukrainian Medical Journal, Год журнала: 2025, Номер 13(1), С. 39 - 54
Опубликована: Янв. 1, 2025
Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2023, Номер 11(5), С. 1465 - 1465
Опубликована: Май 17, 2023
Post-Traumatic Stress Disorder (PTSD) is a chronic psychiatric disorder that occurs following exposure to traumatic events. Recent evidence suggests PTSD may be risk factor for the development of subsequent neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease. Identification biomarkers known associated with neurodegeneration in patients would shed light on pathophysiological mechanisms linking these disorders also help preventive strategies PTSD. With this background, PubMed Scopus databases were searched studies designed identify could an increased Out total 342 citations retrieved, 29 identified inclusion review. The results suggest such as cerebral cortical thinning, disrupted white matter integrity, specific genetic polymorphisms, immune-inflammatory alterations, vitamin D deficiency, metabolic syndrome, objectively documented parasomnias are significantly predict disorders. biological underlying changes, interactions between them, explored. Though requiring replication, findings highlight number pathways plausibly link potentially valuable avenues prevention early intervention.
Язык: Английский
Процитировано
11
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Янв. 27, 2025
Background Posttraumatic stress disorder (PTSD) commonly cooccurs with traumatic brain injury (TBI) in military populations and is a significant predictor of poor long-term outcomes; however, it unclear to what extent specific biological variables are associated comorbidity. This PROSPERO-registered systematic review evaluates the current body literature on genetic peripheral biomarkers comorbid TBI PTSD. Methods Searches were conducted four databases (PubMed, PsycInfo, PTSDPubs, Scopus). We included published studies examining differences among civilian, military, veteran participants both PTSD compared those alone as well as, some cases, healthy controls. Data extracted from evidence quality was assessed. Results Our final analysis 16 studies, majority which based data active duty participants. The results suggest that multiple gene variants likely contribute cumulative risk TBI. An elevated circulating level pro-inflammatory cytokine IL-6 most consistently replicated blood-based indicator illness, mTBI alone. Conclusion Several protein markers cellular inflammation appear be promising indicators chronic pathology Additional research needed determine how such factors indicate, predict, comorbidity they represent viable targets for development novel diagnostic tools therapeutic interventions.
Язык: Английский
Процитировано
0
Behavioral Sciences, Год журнала: 2025, Номер 15(3), С. 343 - 343
Опубликована: Март 11, 2025
Cognitive assessment instruments with emotional components may be useful to address the limitations of self-report scales commonly used assess post-traumatic stress disorder (PTSD) in women victims domestic violence (IPV). The aim this study was develop an Emotional Stroop task designed identify linked intimate partner (IPV) Spanish-speaking women. validation test involved a comparative analysis between two groups: clinical group (n = 50) and non-clinical average age 38.38 (SD 12.31; 100% female participants). indicates that scored significantly higher on PTSD Symptom Severity Scale (EGS) lower three tasks compared group. Notably, there significant negative correlation results modified EGS test. show our adapted serves as efficacious tool for detecting related Moreover, it has potential alleviate constraints presently available tools specific purpose.
Язык: Английский
Процитировано
0
Biological Psychiatry Global Open Science, Год журнала: 2025, Номер unknown, С. 100482 - 100482
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0