Current Pharmacology Reports, Год журнала: 2023, Номер 9(4), С. 177 - 197
Опубликована: Июнь 19, 2023
Язык: Английский
JCI Insight, Год журнала: 2024, Номер 9(3)
Опубликована: Фев. 8, 2024
Aging-related abnormalities in gut microbiota are associated with cognitive decline, depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study demonstrated that transplanting old to young mice induced inflammation the brain coupled anxiety. We observed diminished mucin formation increased permeability ("leaky gut") a reduction beneficial metabolites like butyrate because of decline butyrate-producing bacteria aged microbiota. This led suppressed expression receptors, free fatty acid receptors 2 3 (FFAR2/3). Administering alleviated inflammation, restored barriers, corrected dysfunction. Furthermore, intestine-specific loss FFAR2/3 exhibited akin those older mice. Our results demonstrate reduced result low levels signaling, leading increases permeability, abnormalities. These findings underscore significance butyrate-FFAR2/3 agonism as potential strategy mitigate microbiota-induced detrimental effects on health adults.
Язык: Английский
Процитировано
17
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4387 - 4387
Опубликована: Апрель 16, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex disorder whose prevalence rapidly growing in South America. The disturbances the microbiota–gut–liver axis impact damaging processes toward fibrosis. Gut microbiota status shaped by dietary and lifestyle factors, depending on geographic location. We aimed to identify microbial signatures group of Chilean MASLD patients. Forty subjects were recruited, including healthy controls (HCs), overweight/obese (Ow/Ob), patients with without fibrosis (MASLD/F−), (MASLD/F+). Both detected through elastography and/or biopsy, fecal analyzed deep sequencing. Despite no differences α- β-diversity among all groups, higher abundance Bilophila lower presence Defluviitaleaceae, Lachnospiraceae ND3007, Coprobacter was found MASLD/F− MASLD/F+, compared HC. Ruminococcaceae UCG-013 Sellimonas more abundant MASLD/F+ than Ow/Ob; both significantly differed between Significant positive correlations observed stiffness Bifidobacterium, Prevotella, Sarcina, Acidaminococcus abundance. Our results show that associated changes bacterial taxa are known be involved bile acid metabolism SCFA production, some them being specifically linked
Язык: Английский
Процитировано
11
Experimental Gerontology, Год журнала: 2024, Номер 194, С. 112497 - 112497
Опубликована: Июнь 27, 2024
The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.
Язык: Английский
Процитировано
11
Science Advances, Год журнала: 2025, Номер 11(6)
Опубликована: Фев. 7, 2025
Mucosa-associated invariant T (MAIT) cells are a large population of unconventional widely distributed in the human gastrointestinal tract. Their homing to gut is central maintaining mucosal homeostasis and immunity. This review discusses potential mechanisms that guide MAIT intestinal mucosa during inflammation, emphasizing roles chemokines, chemokine receptors, tissue adhesion molecules. The influence microbiota on cell different regions also discussed. Last, we introduce how organoid technology offers potentially valuable approach advance our understanding by providing more physiologically relevant model mimics tissue. These models may enable detailed investigation gut-specific cells. By regulation gut, avenues for therapeutic interventions targeting inflammatory conditions such as bowel diseases (IBD) emerge.
Язык: Английский
Процитировано
1
Metabolites, Год журнала: 2024, Номер 14(3), С. 155 - 155
Опубликована: Март 7, 2024
A vast range of pesticides have been routinely employed for plant protection throughout the last few decades. Pesticides can enter non-target organisms in various ways, posing health hazards. Exposure to different environmental pollutants, including pesticides, affect human gut flora. Metabolites generated from microbiota play an essential role host's by regulating metabolic homeostasis. disruption this equilibrium lead emergence numerous illnesses and their etiology. shown a recent studies harm microbiome. As result, there is urgent need investigate impact on microbiota-mediated immunity. Metabolic alterations host may give better understanding pesticide-induced harm. This review highlights potential consequences pesticide exposure composition function, mainly focusing how it might alter production secondary metabolites with downstream implications health.
Язык: Английский
Процитировано
7
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(9), С. 931 - 931
Опубликована: Авг. 31, 2024
Aging is a fundamental biological process characterized by progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level crucial for developing interventions that could delay or reverse its effects. This review explores integration of machine learning (ML) with multi-omics technologies-including genomics, transcriptomics, epigenomics, proteomics, metabolomics-in studying hallmarks develop personalized medicine interventions. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis. Using ML analyze big complex datasets helps uncover detailed interactions pathways play role aging. The advances can facilitate discovery biomarkers therapeutic targets, offering insights into anti-aging strategies. With these developments, future points toward better understanding process, aiming ultimately promote healthy extend life expectancy.
Язык: Английский
Процитировано
7
Frontiers in Aging, Год журнала: 2024, Номер 5
Опубликована: Окт. 16, 2024
As we age, our immune system’s ability to effectively respond pathogens declines, a phenomenon known as immunosenescence. This age-related deterioration affects both innate and adaptive immunity, compromising function leading chronic inflammation that accelerates aging. Immunosenescence is characterized by alterations in cell populations impaired functionality, resulting increased susceptibility infections, diminished vaccine efficacy, higher prevalence of diseases. Chronic low-grade further exacerbates these issues, contributing decline overall health resilience. review delves into the characteristics immunosenescence examines various intrinsic extrinsic factors aging how hallmarks fates can play crucial role this process. Additionally, it discusses impact sex, social determinants, gut microbiota on aging, illustrating complex interplay altering function. Furthermore, concept resilience explored, focusing metrics for assessing identifying strategies enhance These include lifestyle interventions such diet, regular physical activity, stress management, use gerotherapeutics other approaches. Understanding mitigating effects are developing support robust responses aged individuals.
Язык: Английский
Процитировано
7
Опубликована: Ноя. 7, 2024
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. a cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.
Язык: Английский
Процитировано
5
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(1), С. 265 - 265
Опубликована: Янв. 5, 2025
Background: Depression often coexists with anemia, potentially sharing common pathways, highlighting the need for treatments addressing both conditions simultaneously. This study evaluated effect of probiotics on red blood cell (RBC) parameters in adults depressive disorder. We hypothesized that would positively influence RBC parameters, modulated by baseline inflammation or dietary intake, improved function correlating better antidepressant outcomes. Methods: secondary analysis a two-arm, randomized, double-blind, controlled trial involved 116 Participants received probiotic formulation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 placebo 60 days. Data from 97 subjects were analyzed including hemoglobin (HGB), count, hematocrit (HCT), mean corpuscular volume (MCV), concentration (MCH), (MCHC), distribution width (RDW). Results: Probiotic supplementation did not result significant changes compared to placebo. However, may help stabilize HGB, HCT, MCH, MCHC levels, preventing fluctuations observed group. Conclusions: While showed potential benefits symptoms, observed. Larger studies are needed clarify mechanisms clinical implications.
Язык: Английский
Процитировано
0
Genes Brain & Behavior, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 13, 2025
ABSTRACT Human microbiota‐associated murine models, using fecal microbiota transplantation (FMT) from human donors, help explore the microbiome's role in diseases like Alzheimer's disease (AD). This study examines how gut bacteria donors with protective factors against AD influence behavior and brain pathology an mouse model. Female 3xTgAD mice received weekly FMT for 2 months (i) 80‐year‐old patient (AD‐FMT), (ii) a cognitively healthy 73‐year‐old APOEe2 allele (APOEe2‐FMT), (iii) 22‐year‐old donor (Young‐FMT), (iv) untreated (Mice‐FMT). Behavioral assessments included novel object recognition (NOR), Y‐maze, open‐field, elevated plus maze tests; (amyloid tau), neuroinflammation (in situ autoradiography of 18 kDa translocator protein hippocampus); were analyzed. APOEe2‐FMT improved short‐term memory NOR test compared to AD‐FMT, without significant changes other behavioral tests. was associated increased hippocampus, but no effect detected on amyloidosis tauopathy. Specific genera, such as Parabacteroides Prevotellaceae_UGC001 , enriched group neuroinflammation, while genera Desulfovibrio reduced linked decreased neuroinflammation. Gut factor induced regions strategic AD. The association several suggests collegial transplanted microbiome rather than single‐microbe driver effect. These data support between bacteria, glial cell activation, cognitive function
Язык: Английский
Процитировано
0