Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

The World Journal of Men s Health, Год журнала: 2019, Номер 37(3), С. 296 - 296

Опубликована: Янв. 1, 2019

Despite advances in the field of male reproductive health, idiopathic infertility, which a man has altered semen characteristics without an identifiable cause and there is no female factor remains challenging condition to diagnose manage.Increasing evidence suggests that oxidative stress (OS) plays independent role etiology with 30% 80% infertile men having elevated seminal reactive oxygen species levels.OS can negatively affect fertility via number pathways, including interference capacitation possible damage sperm membrane DNA, may impair sperm's potential fertilize egg develop into healthy embryo.Adequate evaluation should therefore include assessment OS.We propose term Male Oxidative Stress Infertility, or MOSI, as novel descriptor for abnormal OS, many patients who were previously classified infertility.Oxidation-reduction (ORP) be useful clinical biomarker classification it takes account levels both oxidants reductants (antioxidants).Current treatment protocols use antioxidants, are not evidence-based have complications increased healthcare-related expenditures.Utilizing easy, reproducible, cost-effective

Язык: Английский

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Metabolic Responses to Reductive Stress

Antioxidants and Redox Signaling, Год журнала: 2019, Номер 32(18), С. 1330 - 1347

Опубликована: Июнь 20, 2019

Significance: Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis modulating metabolism. Reductive stress induced by excessive levels of reduced NAD+ (NADH), NADP+ (NADPH), GSH is as harmful oxidative implicated in many pathological processes. Recent Advances: broadens our view the importance influences an imbalanced niche on biological functions, including cell Critical Issues: The distribution NAD(H), NADP(H), GSH/GSH disulfide highly compartmentalized. Understanding how cells coordinate different pools couples under unstressed stressed conditions critical a comprehensive stress. It also to explore underlying mechanisms reductive its consequences, effects energy Future Directions: studies needed investigate affects metabolism adapt their Whether or not NADH shuttles mitochondrial nicotinamide nucleotide transhydrogenase enzyme can regulate hypoxia-induced worthy pursuit. Developing strategies (e.g., antireductant approaches) counteract related adverse consequences requires extensive future efforts.

Язык: Английский

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Oxidative Stress, Plant Natural Antioxidants, and Obesity

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(4), С. 1786 - 1786

Опубликована: Фев. 11, 2021

Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors mitochondrial activity, modifying concentration inflammation mediators associated with a large number and size adipocytes, promoting lipogenesis, stimulating differentiation preadipocytes to mature regulating energy balance hypothalamic neurons that control appetite. This review discusses participation oxidative obesity groups compounds found plants antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, isoflavones), curcuminoids (b) carotenoids, (c) capsaicinoids casinoids, (d) isothiocyanates, (e) catechins, (f) vitamins. Examples are analyzed, resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, garlic. The activities these depend on their reactive oxygen species (ROS) scavengers capacity prevent activation NF-κB (nuclear factor κ-light-chain-enhancer activated B cells), reduce expression target genes, including those participating inflammation. We conclude natural have therapeutic potential for diseases mediated by stress, particularly obesity. Controlled well-designed clinical trials still necessary better know effects compounds.

Язык: Английский

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Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

Medicinal Research Reviews, Год журнала: 2020, Номер 41(2), С. 770 - 784

Опубликована: Июль 13, 2020

Abstract The world's population aging progression renders age‐related neurodegenerative diseases to be one of the biggest unsolved problems modern society. Despite progress in studying development pathology, finding ways for modifying disorders remains a high priority. One common feature is mitochondrial dysfunction and overproduction reactive oxygen species, resulting oxidative stress. Although lipid peroxidation markers stress, it also plays an important role cell physiology, including activation phospholipases stimulation signaling cascades. Excessive hallmark most Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, many other neurological conditions. products have been shown trigger necrotic, apoptotic, more specifically stress‐related, that is, ferroptosis neuronal death. Here we discuss involvement mechanism loss some novel therapeutic directions oppose it.

Язык: Английский

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Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from genetics clinical manifestations and treatment sensitivity. This heterogeneity also reflected in the variety of oxidative stress‐related mechanisms contributing phenotypic realization manifestation schizophrenia. At molecular level, these are supposed include genetic causes that increase susceptibility individuals stress lead gene expression dysregulation caused by abnormal regulation redox‐sensitive transcriptional factors, noncoding RNAs, epigenetic favored environmental insults. These changes form basis prooxidant state altered redox signaling related glutathione deficiency impaired function factors (Nrf2, NF‐ κ B, FoxO, etc.). cellular mitochondrial dysfunction metabolic abnormalities contribute aberrant neuronal development, myelination, neurotransmitter anomalies, parvalbumin‐positive interneurons. Immune contributes imbalance. whole‐organism all ultimately development In this review, we consider new perspectives associated with correction imbalance We suggest not only antioxidants but redox‐regulated transcription factor‐targeting drugs (including Nrf2 FoxO activators or B inhibitors) have great promise But it necessary develop stratification criteria schizophrenia patients based on markers for administration redox‐correcting treatment.

Язык: Английский

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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 23

Опубликована: Окт. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Язык: Английский

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Novel 2D MBenes—Synthesis, Structure, and Biotechnological Potential

Advanced Functional Materials, Год журнала: 2021, Номер 31(38)

Опубликована: Июль 1, 2021

Abstract 2D transition metal borides (MBenes) have emerged as promising post‐MXene materials with potential application in various biotechnological fields. Although they possess prospective bioactive properties due to boron their structure, the experience gained from MXenes shows that an in‐depth understanding of biological recognition and response well exploration applications are highly challenging. This makes identification most MBenes for future research final industrial rather complicated. Herein, differentiated further untangled bioactivity‐generating features. It is expected MBenes’ positive or negative impact on living organisms different types cells connect morphological, structural physicochemical features context relevant environments. Necessary toxicological data also highlighted, which key aspects enable safe biotechnology nanomedicine. Furthermore, a perspective rational development design novel solutions based provided, will meet legal safety requirements nanomaterials. In this regard, work unprecedented contribution toward strategies regulatory MBene/MXene‐type provides inspiration nanotoxicological approaches using MBenes.

Язык: Английский

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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Cell Metabolism, Год журнала: 2023, Номер 35(3), С. 487 - 503.e7

Опубликована: Фев. 24, 2023

Язык: Английский

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Fluorescent probes for biomolecule detection under environmental stress

Journal of Hazardous Materials, Год журнала: 2022, Номер 431, С. 128527 - 128527

Опубликована: Фев. 19, 2022

Язык: Английский

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Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review

Food Science & Nutrition, Год журнала: 2023, Номер 12(2), С. 675 - 693

Опубликована: Дек. 1, 2023

Abstract Reactive oxygen species (ROS) are produced under normal physiological conditions and may have beneficial harmful effects on biological systems. ROS involved in many processes such as differentiation, proliferation, necrosis, autophagy, apoptosis by acting signaling molecules or regulators of transcription factors. In this case, maintaining proper cellular levels is known redox homeostasis. Oxidative stress occurs because the imbalance between production antioxidant defenses. Sources include mitochondria, auto‐oxidation glucose, enzymatic pathways nicotinamide adenine dinucleotide phosphate reduced (NAD[P]H) oxidase. The possible NF‐κB, MAPKs, PI3K‐Akt, Keap1‐Nrf2‐ARE pathway. This review covers literature pertaining to strategies inhibit them. Additionally, summarizes related finding inhibitors.

Язык: Английский

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