Application of Luteolin in Neoplasms and Nonneoplastic Diseases DOI Open Access
Katarzyna Rakoczy, Justyna Kaczor, Adam Sołtyk

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15995 - 15995

Published: Nov. 6, 2023

Researchers are amazed at the multitude of biological effects 3′,4′,5,7-tetrahydroxyflavone, more commonly known as luteolin, it simultaneously has antioxidant and pro-oxidant, well antimicrobial, anti-inflammatory, cancer-preventive, properties. The anticancer properties luteolin constitute a mosaic pathways due to which this flavonoid influences cancer cells. Not only is able induce apoptosis inhibit cell proliferation, but also suppresses angiogenesis metastasis. Moreover, succeeds in sensitization therapeutically induced cytotoxicity. Nevertheless, apart from its promising role chemoprevention, exhibits numerous potential utilizations patients with conditions other than neoplasms, include inflammatory skin diseases, diabetes mellitus, COVID-19. This review aims present multidimensionality luteolin’s impact on both neoplastic nonneoplastic diseases. When comes we intend describe complexity molecular mechanisms that underlay effectiveness, prove usefulness integrating therapy via analysis recent research breast, colon, lung cancer. Regarding emphasize importance researching areas such diabetology, virology, dermatology summarizes most important discoveries those fields regarding application.

Language: Английский

Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility DOI Creative Commons
Ashok Agarwal, Neel Parekh, Manesh Kumar Panner Selvam

et al.

The World Journal of Men s Health, Journal Year: 2019, Volume and Issue: 37(3), P. 296 - 296

Published: Jan. 1, 2019

Despite advances in the field of male reproductive health, idiopathic infertility, which a man has altered semen characteristics without an identifiable cause and there is no female factor remains challenging condition to diagnose manage.Increasing evidence suggests that oxidative stress (OS) plays independent role etiology with 30% 80% infertile men having elevated seminal reactive oxygen species levels.OS can negatively affect fertility via number pathways, including interference capacitation possible damage sperm membrane DNA, may impair sperm's potential fertilize egg develop into healthy embryo.Adequate evaluation should therefore include assessment OS.We propose term Male Oxidative Stress Infertility, or MOSI, as novel descriptor for abnormal OS, many patients who were previously classified infertility.Oxidation-reduction (ORP) be useful clinical biomarker classification it takes account levels both oxidants reductants (antioxidants).Current treatment protocols use antioxidants, are not evidence-based have complications increased healthcare-related expenditures.Utilizing easy, reproducible, cost-effective

Language: Английский

Citations

360
Metabolic Responses to Reductive Stress DOI Creative Commons
Wusheng Xiao, Joseph Loscalzo

Antioxidants and Redox Signaling, Journal Year: 2019, Volume and Issue: 32(18), P. 1330 - 1347

Published: June 20, 2019

Significance: Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis modulating metabolism. Reductive stress induced by excessive levels of reduced NAD+ (NADH), NADP+ (NADPH), GSH is as harmful oxidative implicated in many pathological processes. Recent Advances: broadens our view the importance influences an imbalanced niche on biological functions, including cell Critical Issues: The distribution NAD(H), NADP(H), GSH/GSH disulfide highly compartmentalized. Understanding how cells coordinate different pools couples under unstressed stressed conditions critical a comprehensive stress. It also to explore underlying mechanisms reductive its consequences, effects energy Future Directions: studies needed investigate affects metabolism adapt their Whether or not NADH shuttles mitochondrial nicotinamide nucleotide transhydrogenase enzyme can regulate hypoxia-induced worthy pursuit. Developing strategies (e.g., antireductant approaches) counteract related adverse consequences requires extensive future efforts.

Language: Английский

Citations

328
Oxidative Stress, Plant Natural Antioxidants, and Obesity DOI Open Access
Israel Pérez-Torres, Vicente Castrejón-Téllez, Marí­a Elena Soto

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(4), P. 1786 - 1786

Published: Feb. 11, 2021

Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors mitochondrial activity, modifying concentration inflammation mediators associated with a large number and size adipocytes, promoting lipogenesis, stimulating differentiation preadipocytes to mature regulating energy balance hypothalamic neurons that control appetite. This review discusses participation oxidative obesity groups compounds found plants antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, isoflavones), curcuminoids (b) carotenoids, (c) capsaicinoids casinoids, (d) isothiocyanates, (e) catechins, (f) vitamins. Examples are analyzed, resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, garlic. The activities these depend on their reactive oxygen species (ROS) scavengers capacity prevent activation NF-κB (nuclear factor κ-light-chain-enhancer activated B cells), reduce expression target genes, including those participating inflammation. We conclude natural have therapeutic potential for diseases mediated by stress, particularly obesity. Controlled well-designed clinical trials still necessary better know effects compounds.

Language: Английский

Citations

282
Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention DOI Creative Commons

Plamena R. Angelova,

Noemí Esteras, Andrey Y. Abramov

et al.

Medicinal Research Reviews, Journal Year: 2020, Volume and Issue: 41(2), P. 770 - 784

Published: July 13, 2020

Abstract The world's population aging progression renders age‐related neurodegenerative diseases to be one of the biggest unsolved problems modern society. Despite progress in studying development pathology, finding ways for modifying disorders remains a high priority. One common feature is mitochondrial dysfunction and overproduction reactive oxygen species, resulting oxidative stress. Although lipid peroxidation markers stress, it also plays an important role cell physiology, including activation phospholipases stimulation signaling cascades. Excessive hallmark most Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, many other neurological conditions. products have been shown trigger necrotic, apoptotic, more specifically stress‐related, that is, ferroptosis neuronal death. Here we discuss involvement mechanism loss some novel therapeutic directions oppose it.

Language: Английский

Citations

212
Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives DOI Creative Commons
Evgeny A. Ermakov, E. Dmitrieva,

D. Parshukova

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from genetics clinical manifestations and treatment sensitivity. This heterogeneity also reflected in the variety of oxidative stress‐related mechanisms contributing phenotypic realization manifestation schizophrenia. At molecular level, these are supposed include genetic causes that increase susceptibility individuals stress lead gene expression dysregulation caused by abnormal regulation redox‐sensitive transcriptional factors, noncoding RNAs, epigenetic favored environmental insults. These changes form basis prooxidant state altered redox signaling related glutathione deficiency impaired function factors (Nrf2, NF‐ κ B, FoxO, etc.). cellular mitochondrial dysfunction metabolic abnormalities contribute aberrant neuronal development, myelination, neurotransmitter anomalies, parvalbumin‐positive interneurons. Immune contributes imbalance. whole‐organism all ultimately development In this review, we consider new perspectives associated with correction imbalance We suggest not only antioxidants but redox‐regulated transcription factor‐targeting drugs (including Nrf2 FoxO activators or B inhibitors) have great promise But it necessary develop stratification criteria schizophrenia patients based on markers for administration redox‐correcting treatment.

Language: Английский

Citations

169
ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways DOI Creative Commons
Arthur José Pontes Oliveira de Almeida, Júlio César Pinheiro Lúcio de Oliveira,

Larisse Virgolino da Silva Pontes

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Language: Английский

Citations

161
Novel 2D MBenes—Synthesis, Structure, and Biotechnological Potential DOI
Michał Jakubczak, Aleksandra Szuplewska,

Anita Rozmysłowska‐Wojciechowska

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(38)

Published: July 1, 2021

Abstract 2D transition metal borides (MBenes) have emerged as promising post‐MXene materials with potential application in various biotechnological fields. Although they possess prospective bioactive properties due to boron their structure, the experience gained from MXenes shows that an in‐depth understanding of biological recognition and response well exploration applications are highly challenging. This makes identification most MBenes for future research final industrial rather complicated. Herein, differentiated further untangled bioactivity‐generating features. It is expected MBenes’ positive or negative impact on living organisms different types cells connect morphological, structural physicochemical features context relevant environments. Necessary toxicological data also highlighted, which key aspects enable safe biotechnology nanomedicine. Furthermore, a perspective rational development design novel solutions based provided, will meet legal safety requirements nanomaterials. In this regard, work unprecedented contribution toward strategies regulatory MBene/MXene‐type provides inspiration nanotoxicological approaches using MBenes.

Language: Английский

Citations

125
Fluorescent probes for biomolecule detection under environmental stress DOI
Xiaoyue Han, Yue Wang, Yan Huang

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 431, P. 128527 - 128527

Published: Feb. 19, 2022

Language: Английский

Citations

76
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer DOI Creative Commons
Tommy Weiss‐Sadan, Maolin Ge, Makiko Hayashi

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(3), P. 487 - 503.e7

Published: Feb. 24, 2023

Language: Английский

Citations

76
Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review DOI Creative Commons
Abdur Rauf, Anees Ahmed Khalil, Samir Awadallah

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(2), P. 675 - 693

Published: Dec. 1, 2023

Abstract Reactive oxygen species (ROS) are produced under normal physiological conditions and may have beneficial harmful effects on biological systems. ROS involved in many processes such as differentiation, proliferation, necrosis, autophagy, apoptosis by acting signaling molecules or regulators of transcription factors. In this case, maintaining proper cellular levels is known redox homeostasis. Oxidative stress occurs because the imbalance between production antioxidant defenses. Sources include mitochondria, auto‐oxidation glucose, enzymatic pathways nicotinamide adenine dinucleotide phosphate reduced (NAD[P]H) oxidase. The possible NF‐κB, MAPKs, PI3K‐Akt, Keap1‐Nrf2‐ARE pathway. This review covers literature pertaining to strategies inhibit them. Additionally, summarizes related finding inhibitors.

Language: Английский

Citations

60