International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(14), С. 3439 - 3439
Опубликована: Июль 12, 2019
Magnesium
(Mg)
is
the
second
most
abundant
cation
in
mammalian
cells,
and
it
essential
for
numerous
cellular
processes
including
enzymatic
reactions,
ion
channel
functions,
metabolic
cycles,
signaling,
DNA/RNA
stabilities.
Because
of
versatile
universal
nature
Mg2+,
homeostasis
intracellular
Mg2+
physiologically
linked
to
growth,
proliferation,
differentiation,
energy
metabolism,
death
cells.
On
tissue
levels,
maintaining
within
optimal
levels
according
biological
context,
such
as
cell
types,
developmental
stages,
extracellular
environments,
pathophysiological
conditions,
crucial
development,
normal
diseases.
Hence,
pathologically
involved
cancers,
diabetes,
neurodegenerative
diseases,
Parkinson’s
disease,
Alzheimer’s
demyelination.
In
research
field
regarding
roles
mechanisms
regulation,
controversies
caused
by
its
versatility
complexity
still
exist.
As
at
least,
plays
critical
neuronal
healthy
appropriate
supplementation
exhibits
neurotrophic
effects
a
majority
cases.
control
can
be
candidate
therapeutic
targets
this
review,
recent
results
regulatory
system
determining
phenotype,
fate,
diseases
nervous
are
summarized,
an
overview
comprehensive
provided.
Journal of Advanced Research,
Год журнала:
2021,
Номер
38, С. 223 - 244
Опубликована: Сен. 17, 2021
Recent
research
on
the
implications
of
gut
microbiota
brain
functions
has
helped
to
gather
important
information
relationship
between
them.
Pathogenesis
neurological
disorders
is
found
be
associated
with
dysregulation
gut-brain
axis.
Some
bacteria
metabolites
are
directly
increase
in
reactive
oxygen
species
levels,
one
most
risk
factors
neurodegeneration.
Besides
their
morbid
association,
also
play
a
significant
role
reducing
onset
these
life-threatening
disorders.Studies
done
recent
past
raises
two
link
and
brain:
"gut
microbiota-oxidative
stress-neurodegeneration"
microbiota-antioxidant-neuroprotection.
This
review
aims
gives
deep
insight
our
readers,
collective
studies
done,
focusing
mediated
oxidative
stress
involved
neurodegeneration
along
focus
those
showing
involvement
neuroprotection.This
focused
three
main
key
concepts.
Firstly,
mounting
evidences
from
clinical
preclinical
arenas
shows
influence
resulting
dysfunctional
processes.
Therefore,
we
describe
potential
influencing
vulnerability
stress,
budding
causative
Alzheimer's
Parkinson's
disease.
Secondly,
contributing
roles
been
observed
attenuating
inflammation
via
its
own
or
by
producing
secondary
and,
modulation
population
antioxidative
anti-inflammatory
probiotics
have
shown
promising
neuro
resilience.
Thirdly,
high
throughput
silico
tools
databases
correlation
microbiome,
health,
thus
providing
fascinating
perspective
new
avenues
for
therapeutic
options.
Journal of Clinical Medicine,
Год журнала:
2020,
Номер
9(2), С. 430 - 430
Опубликована: Фев. 5, 2020
The
brain
is
the
body's
control
center,
so
when
a
disease
affects
it,
outcomes
are
devastating.
Alzheimer's
and
Parkinson's
disease,
multiple
sclerosis
diseases
that
cause
large
number
of
human
deaths
worldwide.
Curcumin
has
demonstrated
beneficial
effects
on
health
through
several
mechanisms
such
as
antioxidant,
amyloid
β-binding,
anti-inflammatory,
tau
inhibition,
metal
chelation,
neurogenesis
activity,
synaptogenesis
promotion.
therapeutic
limitation
curcumin
its
bioavailability,
to
address
this
problem,
new
nanoformulations
being
developed.
present
review
aims
summarize
general
bioactivity
in
neurological
disorders,
how
functional
molecules
extracted,
different
types
available.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2021,
Номер
11
Опубликована: Ноя. 4, 2021
As
a
complex
multicellular
structure
of
the
vascular
system
at
central
nervous
(CNS),
blood-brain
barrier
(BBB)
separates
CNS
from
circulation
and
regulates
influx
efflux
substances
to
maintain
steady-state
environment
CNS.
Lipopolysaccharide
(LPS),
cell
wall
component
Gram-negative
bacteria,
can
damage
function
BBB
further
promote
occurrence
development
sepsis-associated
encephalopathy
(SAE).
Here,
we
conduct
literature
review
direct
indirect
mechanisms
LPS
relationship
between
these
processes
SAE.
We
believe
that
after
destroys
BBB,
large
number
inflammatory
factors
neurotoxins
will
enter
brain
tissue,
which
activate
immune
cells
mediate
response
in
turn
BBB.
This
vicious
circle
ultimately
lead
progression
Finally,
present
succinct
overview
treatment
SAE
by
restoring
summarize
novel
opportunities
controlling
targeting
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Perimenopause
is
an
important
stage
of
female
senescence.
Epidemiological
investigation
has
shown
that
the
incidence
cardiovascular
disease
in
premenopausal
women
lower
than
men,
and
postmenopausal
significantly
higher
men.
This
phenomenon
reveals
estrogen
a
definite
protective
effect
on
system.
In
system,
oxidative
stress
considered
pathogenesis
atherosclerosis,
myocardial
dysfunction,
cardiac
hypertrophy,
heart
failure,
ischemia.
From
perspective
stress,
plays
regulatory
role
system
through
receptor,
providing
strategies
for
treatment
menopausal
with
diseases.
Marine Drugs,
Год журнала:
2021,
Номер
19(10), С. 531 - 531
Опубликована: Сен. 23, 2021
Acute
inflammation
is
a
key
component
of
the
immune
system's
response
to
pathogens,
toxic
agents,
or
tissue
injury,
involving
stimulation
defense
mechanisms
aimed
removing
pathogenic
factors
and
restoring
homeostasis.
However,
uncontrolled
acute
inflammatory
may
lead
chronic
inflammation,
which
involved
in
development
many
diseases,
including
cancer.
Nowadays,
need
find
new
potential
therapeutic
compounds
has
raised
worldwide
scientific
interest
study
marine
environment.
Specifically,
microalgae
are
considered
rich
sources
bioactive
molecules,
such
as
carotenoids,
natural
isoprenoid
pigments
with
important
beneficial
effects
for
health
due
their
biological
activities.
Carotenoids
essential
nutrients
mammals,
but
they
unable
synthesize
them;
instead,
dietary
intake
these
required.
classified
carotenes
(hydrocarbon
carotenoids),
α-
β-carotene,
xanthophylls
(oxygenate
derivatives)
zeaxanthin,
astaxanthin,
fucoxanthin,
lutein,
β-cryptoxanthin,
canthaxanthin.
This
review
summarizes
present
up-to-date
knowledge
anti-inflammatory
anticancer
activities
microalgal
carotenoids
both
vitro
vivo,
well
latest
status
human
studies
use
prevention
treatment
diseases
World Journal of Diabetes,
Год журнала:
2023,
Номер
14(3), С. 130 - 146
Опубликована: Март 15, 2023
Insulin
resistance
and
pancreatic
β-cell
dysfunction
are
major
pathological
mechanisms
implicated
in
the
development
progression
of
type
2
diabetes
(T2D).
Beyond
detrimental
effects
insulin
resistance,
inflammation
oxidative
stress
have
emerged
as
critical
features
T2D
that
define
dysfunction.
Predominant
markers
such
C-reactive
protein,
tumor
necrosis
factor
alpha,
interleukin-1β
consistently
associated
with
failure
preclinical
models
people
T2D.
Similarly,
important
stress,
increased
reactive
oxygen
species
depleted
intracellular
antioxidants,
consistent
damage
conditions
Such
illustrate
a
relationship
between
an
abnormal
inflammatory
response
generation
during
The
current
review
explores
clinical
research
on
patho-logical
implications
Moreover,
molecular
relevant
biomarkers
involved
this
process
discussed
to
divulge
link
Underpinning
relevance
review,
systematic
analysis
evidence
from
randomized
controlled
trials
is
covered,
potential
therapeutic
some
commonly
used
antidiabetic
agents
modulating
makers
improve
function.
