Life Sciences, Год журнала: 2019, Номер 239, С. 117043 - 117043
Опубликована: Ноя. 10, 2019
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(17), С. 10020 - 10020
Опубликована: Сен. 2, 2022
Alzheimer’s disease (AD) is a neurodegenerative with high morbidity and mortality, for which there no available cure. Currently, it generally believed that AD caused by multiple factors, such as amyloid-beta accumulation, tau protein hyperphosphorylation, oxidative stress, inflammation. Multitarget prevention treatment strategies are recommended. Interestingly, naturally occurring dietary flavonoids, class of polyphenols, have been reported to biological activities anti-AD effects in several models owing their antioxidative, anti-inflammatory, anti-amyloidogenic properties. In this review, we summarize discuss the existing pathogenic factors AD. Moreover, further elaborate on natural flavonoids potential mode action targets managing presenting wide range experimental evidence. The gathered data indicate can be regarded prophylactics slow advancement or avert its onset. Different different varying levels activity. Further, review summarizes structure–activity relationship based literature provide guidance design selection drugs.
Язык: Английский
Процитировано
40
Molecular Neurodegeneration, Год журнала: 2022, Номер 17(1)
Опубликована: Май 7, 2022
Abstract Modulation of basic biochemical and physiological processes by the circadian timing system is now recognized as a fundamental feature all mammalian organ systems. Within central nervous system, these clock-modulating effects are reflected in some most complex behavioral states including learning, memory, mood. How clock shapes only beginning to be realized. In this review we describe recent findings regarding set cellular signaling events, kinase pathways, gene networks, synaptic circuits that under influence how this, turn, cognitive capacity over cycle. Further, discuss functional roles master located suprachiasmatic nucleus, peripheral oscillator populations within cortical limbic circuits, gating plasticity memory These then used basis connection between dysregulation impairments resulting from Alzheimer’s disease (AD). addition, conceptually novel idea AD, there selective disruption it disruption/desynchronization regions phase-entraining SCN underlies aspects early- mid-stage deficits AD. prospect AD could produce self-reinforcing feedback loop, where accelerates pathogenesis (e.g., amyloid deposition, oxidative stress cell death) turn leads further system. Lastly, address potential therapeutic approaches strengthen networks and, improve patients.
Язык: Английский
Процитировано
38
Aging Cell, Год журнала: 2022, Номер 21(10)
Опубликована: Сен. 3, 2022
Abstract With the aging world population, prevalence of aging‐related disorders is on rise. Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age‐related, most these diseases comorbidities or risk factors for AD; however, our understandings molecular events that regulate occurrence still not fully understood. Brain muscle Arnt‐like protein‐1 (Bmal1) an irreplaceable clock gene governs multiple important physiological processes. Continuous research Bmal1 in AD associated ongoing, this review picks relevant studies a detailed account its role mechanisms diseases. Oxidative stress inflammation turned out to be common by which deficiency promotes diseases, other Bmal1‐dependent remain identified. Promising therapeutic strategies involved regulation provided, including melatonin, natural compounds, metformin, d‐Ser2‐oxyntomodulin, interventions, exercise, time‐restricted feeding, adiponectin. The establishment signaling pathway network will lead advances comprehension cellular mechanisms, shedding light novel treatments promoting aging‐associated brain health.
Язык: Английский
Процитировано
38
Antioxidants, Год журнала: 2023, Номер 12(3), С. 586 - 586
Опубликована: Фев. 27, 2023
Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.
Язык: Английский
Процитировано
35
Cancer Cell International, Год журнала: 2023, Номер 23(1)
Опубликована: Сен. 24, 2023
Paclitaxel is a natural anticancer compound with minimal toxicity, the capacity to stabilize microtubules, and high efficiency that has remained standard of treatment alongside platinum-based therapy as remedy for variety different malignancies. In contrast, polyphenols such flavonoids are also efficient antioxidant anti-inflammatory have now been shown possess potent properties. Therefore, synergistic effects paclitaxel against cancer will be interest. this review, we use Boolean query comprehensively search well-known Scopus database literature research taking advantage simultaneously while treating various types cancer. After retrieving reviewing intended investigations based on input keywords, mechanisms their targets raging from cell lines animal models discussed in terms corresponding involved signaling transduction. Most studies demonstrated these pathways induce apoptotic / pro-apoptotic proteins, which turn may activate several caspases leading apoptosis. Finally, it can concluded results review beneficial serving theoretical foundation reference future synthesis, processes, clinical applications involving trials.
Язык: Английский
Процитировано
32
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9236 - 9236
Опубликована: Май 25, 2023
Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, anticarcinogenic properties. Furthermore, they also neuroprotective cardioprotective effects. Their biological properties depend on the chemical structure flavonoids, mechanism action, bioavailability. The beneficial effects flavonoids been proven for variety diseases. In last few years, it is demonstrated that mediated by inhibiting NF-κB (Nuclear Factor-κB) pathway. this review, we summarized some most common diseases, such as cancer, cardiovascular, human neurodegenerative Here, collected all recent studies describing protective prevention role derived from plants specifically focusing action signaling
Язык: Английский
Процитировано
28
Antioxidants, Год журнала: 2023, Номер 12(1), С. 180 - 180
Опубликована: Янв. 12, 2023
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS
Язык: Английский
Процитировано
24
Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102224 - 102224
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
14
Heliyon, Год журнала: 2024, Номер 10(13), С. e33670 - e33670
Опубликована: Июнь 26, 2024
Inflammation is a complex physiological phenomenon, which the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to inflammatory response. AMPK, as key sensor of cellular energy status, plays crucial role in regulating homeostasis glycolipid metabolism. In recent years, anti-inflammation effect AMPK signalling cascade has begun enter everyone's field vision – not least impact on metabolic diseases. A great number studies shown that anti-inflammatory drugs work through pathways.Herein, this article summarises advances compounds show effects by activating attempts comment them.
Язык: Английский
Процитировано
12
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(5), С. 2411 - 2433
Опубликована: Янв. 29, 2024
As an important signaling pathway in multicellular eukaryotes, the Wnt participates a variety of physiological processes. Recent studies have confirmed that plays role neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. The regulation by natural compounds herbal medicines nutraceuticals has emerged potential strategy for development new drugs disorders.
Язык: Английский
Процитировано
10