Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Язык: Английский

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Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer’s Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation, Cholinesterase, Tau Degradation, and Oxidative Stress

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(14), С. 2545 - 2564

Опубликована: Июль 9, 2024

Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative and remains formidable global health challenge. The current medication for AD gives symptomatic relief and, thus, urges us to look alternative disease-modifying therapies based on multitarget directed approach. Looking at the remarkable progress made in peptide drug development last decade benefits associated with peptides, they offer valuable chemotypes [multitarget ligands (MTDLs)] as therapeutics. This review recapitulates developments harnessing peptides MTDLs combating by targeting multiple key pathways involved disease's progression. hold immense potential represent convincing avenue pursuit of novel While hurdles remain, ongoing research offers hope that may eventually provide approach combat AD.

Язык: Английский

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Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 2966 - 2981

Опубликована: Июль 31, 2024

Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.

Язык: Английский

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Unlocking Hope: Therapeutic Advances and Approaches in Modulating the Wnt Pathway for Neurodegenerative Diseases

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Язык: Английский

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Lycium barbarum extract improves brain and visual functions in mice models of Alzheimer's disease through activating WNT pathway

Phytomedicine, Год журнала: 2025, Номер 139, С. 156523 - 156523

Опубликована: Фев. 17, 2025

Язык: Английский

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Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders

Brain Sciences, Год журнала: 2025, Номер 15(3), С. 252 - 252

Опубликована: Фев. 27, 2025

Neurological disorders are defined by a deterioration or disruption of the nervous system’s structure and function. These diseases, which include multiple sclerosis, Alzheimer’s disease, Parkinson’s Huntington’s schizophrenia, caused intricate pathological processes that excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, compromised neurotrophic signaling. Although current pharmaceutical treatments relieve symptoms, their long-term efficacy is limited due to adverse side effects weak neuroprotective properties. However, when combined with other drugs adjunct therapy, they may offer additional benefits improve treatment outcomes. Phytochemicals have emerged as attractive therapeutic agents ability regulate essential pathways, especially brain-derived factor (BDNF) signaling cascade. BDNF an important target for neurodegenerative disease (ND) since it regulates neuronal survival, synaptic plasticity, neurogenesis, neuroprotection. This review emphasizes molecular pathways through various phytochemicals—such flavonoids, terpenoids, alkaloids, phenolic compounds—stimulate expression modulate its downstream including GSK-3β, MAPK/ERK, PI3K/Akt/mTOR, CREB, Wnt/β-catenin. paper also highlights how phytochemical combinations interact enhance activity, offering new options ND treatment. Despite potential neuroprotection, phytochemicals face challenges related pharmacokinetics, blood–brain barrier (BBB) permeability, absorption, highlighting need further research into combination therapies improved formulations. Clinical assessment mechanistic understanding BDNF-targeted phytotherapy should be main goals future studies. The natural compounds in regulating highlighted this review, providing viable approach prevention NDs.

Язык: Английский

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THE NUTRACEUTICAL MARKET: INTELLECTUAL PROPERTY, CLINICAL RESEARCH, AND FUTURE INSIGHTS

International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 39 - 52

Опубликована: Март 7, 2025

The global nutraceuticals industry is a dynamic and rapidly evolving sector with diverse products, each offering numerous health benefits that significantly impact behaviours market trends. evaluation of patents within this reveals the dual nature intellectual property rights as both tool for fostering innovation potential barrier. However, growing recognition these nutraceutical products face challenges ensuring product integrity, particularly in addressing issues such adulteration substandard quality. Key aspects include its potential, company challenges, adulteration, rights, identification techniques will ensure public access to safe effective products. In core relationships between regulations, paper identifies several critical pathways advancing practices like strengthening regulatory oversight, encouraging through promoting ethical investing research development, enhancing international collaboration. Also, it focuses on environment promotes accessibility stakeholders who can contribute meaningfully objectives. There are parameters high-cost complex landscapes, consumer skepticism, technologies artificial intelligence machine learning streamline development help tailor strategies address specific needs. insights collaboration among organizations crucial improving well-being positively by shaping future sector. Therefore, governments, stakeholders, researchers, civil society. necessary relationship regulation, promotion industry.

Язык: Английский

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STCDB4ND: a signal transduction classification database for neurological diseases

Database, Год журнала: 2025, Номер 2025

Опубликована: Янв. 1, 2025

Abstract Neurological disorders pose significant global health challenges due to their complex etiology and insufficient understanding of underlying mechanisms. Signal transduction pathways are critical in the pathophysiology these diseases have been extensively studied develop therapeutic interventions. However, existing databases for biological signal often overlook dynamic interactions between entities within lack standardized representations signaling processes. To address limitations, we present STCDB4ND, a specialized database focused on associated with neurological diseases. Utilizing ST classification system, STCDB4ND provides unified framework pathway representation, emphasizing characteristics. The features advanced visualization tools, network analysis capabilities, key factor identification module, enabling researchers comprehensively study networks. Our disease-related using revealed factors supported findings pathogenic mechanisms serves as valuable resource advancing disease promoting novel approaches. And believe that STCDB will provide greater convenience various fields expand system’s future. Database URL: https://bis.zju.edu.cn/STCDB

Язык: Английский

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Identification of potential inhibitors of Fyn-Kinase from bioactive phytochemicals of Berberis lycium for therapeutic targeting of neurodegenerative disease

Journal of Biomolecular Structure and Dynamics, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Фев. 24, 2025

Fyn is classified as a member of the Src family kinases (SFKs), group non-receptor tyrosine kinases. It critical component many fundamental central nervous system (CNS) processes. Recently, connection has been shown between malfunction and pathogenic processes exhibited in neurodegenerative conditions, such Alzheimer's disease (AD), which significant factor worldwide mortality disability. Due to rising demographic elderly individuals, there projected increase incidence AD forthcoming years. This study aims identify prospective phytochemicals that can be utilized developing new protein kinase inhibitor for therapeutic intervention AD. The lack interventions capable preventing progression concern thus, it imperative potential targets. employed virtual screening approach discover Fyn-kinase inhibitors from Berberis lycium (B.ly.) phytoconstituents. Three molecules, Canadine, N-Methyltetrahydroberberine (N-MTHB), Tetrahydroberberine (THB), were found have strong affinity binding pocket kinase. docked complexes B.ly. compounds with underwent all-atom molecular dynamics (MD) simulations assess their stability interactions. MD simulation analysis revealed identified show promise inhibitors, may implicated management

Язык: Английский

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Equipping Uridine with Three Dipeptide Motifs for the Inhibition of Radical-Induced DNA Oxidation

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13059 - 13070

Опубликована: Авг. 29, 2024

We report the discovery and characterization of antioxidative effects uridine linked with three dipeptide motifs against DNA oxidation induced by peroxyl radicals. First, are constructed using Ugi four-component reaction (Ugi 4CR), in which caffeic, ferulic, sinapic, syringic acids used as carboxylic acid resources, vanillin, benzaldehyde,

Язык: Английский

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