Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Cellular senescence is characterized by the permanent arrest of cell proliferation and a response to endogenous exogenous stress. The continuous accumulation senescent cells (SnCs) in body leads development aging age-related diseases (such as neurodegenerative diseases, cancer, metabolic cardiovascular osteoarthritis). In face growing challenge several compounds have received widespread attention for their potential target SnCs. As result, senolytics (compounds that selectively eliminate SnCs) senomorphics alter intercellular communication modulate behavior become hot research topics field anti-aging. addition, strategies such combination therapies immune-based approaches also made significant progress anti-aging therapy. this article, we discuss latest on targeting SnCs gain deeper understanding mechanism action impact different with aim providing more effective references therapeutic ideas clinical treatment ever-grave challenges diseases.

Язык: Английский

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Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

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Nobiletin and Eriodictyol Suppress Release of IL-1β, CXCL8, IL-6, and MMP-9 from LPS, SARS-CoV-2 Spike Protein, and Ochratoxin A-Stimulated Human Microglia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 636 - 636

Опубликована: Янв. 14, 2025

Neuroinflammation is involved in various neurological and neurodegenerative disorders which the activation of microglia one key factors. In this study, we examined anti-inflammatory effects flavonoids nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) eriodictyol (3′,4′,5,7-tetraxydroxyflavanone) on human cell line stimulated by either lipopolysaccharide (LPS), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length Spike protein (FL-Spike), or mycotoxin ochratoxin A (OTA). Human were preincubated with (10, 50, 100 µM) for h, following which, they 24 h. The inflammatory mediators interleukin-1 beta (IL-1β), chemokine (C-X-C motif) ligand 8 (CXCL8), IL-6, matrix metalloproteinase-9 (MMP-9) quantified culture supernatant enzyme-linked immunosorbent assay (ELISA). Both significantly inhibited LPS, FL-Spike, OTA-stimulated release IL-1β, CXCL8, MMP-9 at 50 µM, while, most cases, was also effective 10 pronounced reductions µM. These findings suggest that both are potent inhibitors pathogen-stimulated microglial mediators, highlighting their potential therapeutic application neuroinflammatory diseases, such as long COVID.

Язык: Английский

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Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(20), С. 5090 - 5090

Опубликована: Окт. 14, 2019

Ageing is an inevitable fundamental process for people and their greatest risk factor neurodegenerative disease. The ageing processes bring changes in cells that can drive the organisms to experience loss of nutrient sensing, disrupted cellular functions, increased oxidative stress, homeostasis, genomic instability, accumulation misfolded protein, impaired defenses telomere shortening. Perturbation these vital neuronal lead life threatening neurological disorders like Alzheimer’s Disease, Parkinson’s Huntington’s Lewy body dementia, etc. Disease most frequent cause deaths elderly population. Various therapeutic molecules have been designed overcome social, economic health care burden caused by Disease. Almost all chemical compounds clinical practice found treat symptoms only limiting them palliative care. reason behind such imperfect drugs may result from inefficiencies current target Here, we review potential role antioxidant polyphenolic could possibly be effective preventative strategy against

Язык: Английский

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Amentoflavone suppresses amyloid β1–42 neurotoxicity in Alzheimer's disease through the inhibition of pyroptosis

Life Sciences, Год журнала: 2019, Номер 239, С. 117043 - 117043

Опубликована: Ноя. 10, 2019

Язык: Английский

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