International Journal of Biological Macromolecules, Год журнала: 2020, Номер 157, С. 267 - 275
Опубликована: Апрель 25, 2020
Язык: Английский
Nanomaterials, Год журнала: 2020, Номер 10(9), С. 1700 - 1700
Опубликована: Авг. 29, 2020
Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging cancer therapy. They make excellent drug carriers, contrast agents, photothermal photoacoustic radiation dose enhancers, among other applications. Recent advances nanotechnology have led to the use of nanomaterials many areas functional imaging, therapy, synergistic combinational platforms. This review will systematically explore various applications The medical modalities include magnetic resonance computed tomography, positron emission single photon computerized optical ultrasound, imaging. Various therapeutic methods also be included, including photodynamic chemotherapy, immunotherapy. covers theranostics, which same agent diagnosis includes recent multimodality image-guided combination We found that continuous synthesis design novel enhance future development However, more resources should available examine side effects cell toxicity when using humans.
Язык: Английский
Процитировано
308
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 137, С. 111302 - 111302
Опубликована: Янв. 29, 2021
Photodynamic Therapy (PDT) has been known for over a hundred years, and currently gaining in acceptance as an alternative cancer treatment. Light delivery is still difficult problem deep treatment with PDT. Only near-infrared light the 700−1100 nm range can penetrate deeply into tissue because most chromophores, including oxyhemoglobin, deoxyhemoglobin, melanin fat, poorly absorb near infrared window. The sources used PDT are lasers, arc lamps, light-emitting diodes fluorescent lamps. many different clinical applications. may be excellent diagnosis of breast compared to conventional surgery, chemotherapy radiotherapy. basic elements appropriate photosensitizer (PS), oxygen, light. effectiveness photodynamic therapy depends on induction photocytotoxic reactions, which result activation PS), pre-administered body. condition initiating processes absorption by PS subsequent localized generation cytotoxic reactive oxygen species. This study review empirical research aimed at improving using based physicochemical differences healthy diseased tissues undergoing
Язык: Английский
Процитировано
124
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 82, С. 104357 - 104357
Опубликована: Март 12, 2023
Язык: Английский
Процитировано
51
Cancers, Год журнала: 2020, Номер 12(10), С. 2793 - 2793
Опубликована: Сен. 29, 2020
Current research to find effective anticancer treatments is being performed on photodynamic therapy (PDT) with increasing attention. PDT a very promising therapeutic way combine photosensitive drug visible light manage different intense malignancies. has several benefits, including better safety and lower toxicity in the treatment of malignant tumors over traditional cancer therapy. This reasonably simple approach utilizes three integral elements: photosensitizer (PS), source light, oxygen. Upon irradiation particular wavelength, PS generates reactive oxygen species (ROS), beginning cascade cellular death transformations. The positive impact may be limited because factors this include low solubilities PSs, restricting their administration, blood circulation, poor tumor specificity. Therefore, utilizing nanocarrier systems that modulate pharmacokinetics (PK) pharmacodynamics (PD) bypassing these challenges. In present paper, we review latest clinical studies preclinical vivo use progress made nanotherapeutics as delivery tools for PSs improve uptake toxic properties and, therefore, PDT. We also discuss effects photoimmunotherapy (PIT) might have solid strategies.
Язык: Английский
Процитировано
118
Frontiers in Chemistry, Год журнала: 2021, Номер 9
Опубликована: Апрель 22, 2021
Nanotechnology advances in cancer therapy applications have led to the development of nanomaterials that generate cytotoxic reactive oxygen species (ROS) specifically tumor cells. ROS act as a double-edged sword, they can promote tumorigenesis and proliferation but also trigger cell death by enhancing intracellular oxidative stress. Various function increasing production cells thereby disturbing their redox balance, leading lipid peroxidation, damage DNA proteins. In this review, we outline these mechanisms, summarize recent progress ROS-based nanomaterials, including metal-based nanoparticles, organic chemotherapy drug-loaded nanoplatforms, highlight biomedical drug delivery systems (DDSs) or combination with chemodynamic (CDT), photodynamic (PDT), sonodynamic (SDT). Finally, discuss advantages limitations current ROS-mediated used speculate on future nanotechnology for oncological applications.
Язык: Английский
Процитировано
72
Molecules, Год журнала: 2021, Номер 26(21), С. 6532 - 6532
Опубликована: Окт. 29, 2021
Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women's physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels reactive oxygen species (ROS). Compared free photosensitizers, use nanoparticles shows great terms solubility, early degradation, biodistribution, as well more effective intercellular penetration targeted cell uptake. Under current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) can be achieved through non-covalent (self-aggregation, interfacial deposition, polymerization or core-shell embedding adsorption) covalent (chemical immobilization coupling) processes accumulate certain tumors passive and/or active targeting. These PS loading methods provide chemical stability payload. Among nanoparticles, metal high stability, adjustable size, optical properties, easy surface functionalization, making them biocompatible biological applications. this review, we summarize development application status for breast cancer, especially latest developments nanocarriers PDT, highlight some synergistic therapies, hopefully providing an accessible overview knowledge that may act a basis new ideas systematic evaluations already results.
Язык: Английский
Процитировано
70
Photodiagnosis and Photodynamic Therapy, Год журнала: 2021, Номер 33, С. 102205 - 102205
Опубликована: Фев. 7, 2021
Язык: Английский
Процитировано
64
Frontiers in Oncology, Год журнала: 2022, Номер 11
Опубликована: Янв. 19, 2022
In recent years, the morbidity and mortality of gastrointestinal cancer have remained high in China. Due to deep location organs, such as gastric cancer, early symptoms are not obvious. It is generally discovered at an advanced stage with distant metastasis lymph node infiltration, making it difficult cure. Therefore, there a significant need for novel technologies that can effectively diagnose treat ultimately reducing its mortality. Gold nanoparticles (GNPs), type nanocarrier unique optical properties remarkable biocompatibility, potential influence fate by delivering drugs, nucleic acids cells tissues. As safe reliable visualization agent, GNPs track drugs accurately indicate boundaries opening up new possibilities treatment. addition, been used photodynamic therapy deliver photosensitizers, well combination photothermal therapy. be effective nanomaterial treatment diagnosis cancer.
Язык: Английский
Процитировано
62
Pharmaceutics, Год журнала: 2022, Номер 14(2), С. 438 - 438
Опубликована: Фев. 18, 2022
Recently, several studies have indicated an increased interest in the scientific community regarding application of Cannabis sativa plants, and their extracts, for medicinal purposes. This plant enormous potential has been legalised increasing number countries globally. Due to recent changes therapeutic recreational legislation, cannabis cannabinoids are now frequently permitted use clinical settings. However, with highly lipophilic features very low aqueous solubility, prone degradation, specifically solution, as they light-, temperature-, auto-oxidation-sensitive. Thus, plant-derived developed oral, nasal-inhalation, intranasal, mucosal (sublingual buccal), transcutaneous (transdermal), local (topical), parenteral deliveries. Among these administrations routes, topical transdermal products usually a higher bioavailability rate prolonged steady-state plasma concentration. Additionally, eliminate psychotropic impacts drug by its diffusion into nonreactive, dead stratum corneum. modality avoids oral administration and, thus, first-pass metabolism, leading constant cannabinoid levels. review article investigates practicality delivering via skin accordance existing literature.
Язык: Английский
Процитировано
42
View, Год журнала: 2023, Номер 4(2)
Опубликована: Март 3, 2023
Abstract Nanobiotechnology is one of the leading research areas in biomedical science, developing rapidly worldwide. Among various types nanoparticles, carbon nanomaterials (CNMs) have attracted a great deal attention from scientific community, especially with respect to their prospective application field disease diagnosis and therapy. The unique features these nanomaterials, including favorable size, high surface area, electrical, structural, optical, chemical properties, provided an excellent opportunity for utilization theranostic systems. Carbon nanotubes, quantum dots, graphene, fullerene are most employed CNMs fields. They been considered safe efficient non‐invasive diagnostic techniques such as fluorescence imaging, magnetic resonance biosensors. Various functionalized exhibit capacity improve cell targeting anticancer drugs. Due thermal they extensively used cancer photothermal photodynamic therapy assisted by laser irradiation CNMs. also can cross blood‐brain barrier potential treat brain disorders, instance, neurodegenerative diseases, removing amyloid fibrils. This review has summarized emphasized on recent advances
Язык: Английский
Процитировано
42