Fuel, Год журнала: 2022, Номер 323, С. 124277 - 124277
Опубликована: Апрель 26, 2022
Язык: Английский
Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1313 - 1313
Опубликована: Апрель 21, 2023
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.
Язык: Английский
Процитировано
285
International Journal of Nanomedicine, Год журнала: 2020, Номер Volume 15, С. 9407 - 9430
Опубликована: Ноя. 1, 2020
Abstract: The rapid development of nanotechnology offers a variety potential therapeutic strategies for cancer treatment. High atomic element nanomaterials are often utilized as radiosensitizers due to their unique photoelectric decay characteristics. Among them, gold nanoparticles (GNPs) one the most widely investigated and considered be an ideal radiotherapy high X-ray absorption physicochemical properties. Over last few decades, multi-disciplinary studies have focused on design optimization GNPs achieve greater dosing capability higher effects highlight mechanisms radiosensitization GNPs. Although radiosensitizing has been recognized, its clinical translation still faces many challenges. This review analyses different roles in summarizes recent advances. In addition, underlying GNP radiosensitization, including physical, chemical biological discussed, which may provide new directions transformation next-generation Keywords: nanoparticles, radiotherapy,
Язык: Английский
Процитировано
231
Materials, Год журнала: 2021, Номер 14(20), С. 5978 - 5978
Опубликована: Окт. 11, 2021
Carbon nanomaterials (CNMs) have received tremendous interest in the area of nanotechnology due to their unique properties and flexible dimensional structure. CNMs excellent electrical, thermal, optical that make them promising materials for drug delivery, bioimaging, biosensing, tissue engineering applications. Currently, there are many types CNMs, such as quantum dots, nanotubes, nanosheets, nanoribbons; others development promise exciting applications future. The surface functionalization modifies chemical physical properties, which enhances loading/release capacity, ability target delivery specific sites, dispersibility suitability biological systems. Thus, been effectively used different biomedical This review explores physical, chemical, allow improve on state art currently discussion also embraces emerging including targeted medical implants, engineering, wound healing, vaccination, photodynamic therapy.
Язык: Английский
Процитировано
209
Life Sciences, Год журнала: 2021, Номер 269, С. 119087 - 119087
Опубликована: Янв. 19, 2021
Язык: Английский
Процитировано
184
Chemical Engineering Journal, Год журнала: 2020, Номер 408, С. 127245 - 127245
Опубликована: Окт. 8, 2020
Язык: Английский
Процитировано
170
Molecules, Год журнала: 2020, Номер 25(23), С. 5649 - 5649
Опубликована: Ноя. 30, 2020
The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads pathological tissues, producing enhanced outcome reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise purpose, which could protect from metabolism degradation during in vivo circulation exhibit responsive release therapeutics triggered by especially cancer treatment. In past decades, methodologies, such as cleavage linkage, have been applied fabrication pH-responsive materials both vitro applications. this review, we will summarize some system medical application, mainly focusing on linkage bonds biomaterials.
Язык: Английский
Процитировано
161
Biosensors and Bioelectronics, Год журнала: 2022, Номер 216, С. 114674 - 114674
Опубликована: Сен. 1, 2022
Язык: Английский
Процитировано
142
Polymers, Год журнала: 2021, Номер 13(11), С. 1717 - 1717
Опубликована: Май 24, 2021
Breast cancer remains one of the world's most dangerous diseases because difficulty finding cost-effective and specific targets for effective efficient treatment methods. The biodegradability biocompatibility properties chitosan-based nanoparticles (ChNPs) have good prospects targeted drug delivery systems. ChNPs can transfer various antitumor drugs to sites via passive active targeting pathways. modification has attracted researcher loading cells. objective our review was summarize discuss in delivering anticancer against breast cells from published papers recorded Scopus, PubMed, Google Scholar. In order improve cellular uptake, accumulation, cytotoxicity, selectivity, we examined different kinds ChNPs. Notably, these forms use characteristics enhanced permeability retention (EPR) effect as a proper parameter biological ligands, such proteins, peptides, monoclonal antibodies, small particles. addition, system, provided significantly improved into (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). conclusion, promising technique is presented increasing efficacy, effectiveness candidate carriers cancer.
Язык: Английский
Процитировано
137
Heliyon, Год журнала: 2021, Номер 7(4), С. e06914 - e06914
Опубликована: Апрель 1, 2021
Metal-organic frameworks (MOFs) are a fascinating class of crystalline porous materials composed metal ions and organic ligands. Due to their attractive properties, MOFs can potentially offer biomedical field applications, such as drug delivery imaging. This study aimed systematically identify the affecting factors on MOF characteristics effects structural biological characteristics. An electronic search was performed in four databases containing PubMed, Scopus, Web Science, Embase, using relevant keywords. After analyzing studies, 20 eligible studies were included this review. As result, various additives ligand influence size structure MOFs. Additives that compete with may affect nucleation growth processes and, consequently, particle size. The nature influential determining MOF. Moreover, synthesis parameters like reaction time initial reagents ratio critical should be optimized regulate structure. Of note is suitable additive control porosity more extended ligands aid forming large pores. choice metallic nodes ligand, concentration important since they determine toxicity biocompatibility final physicochemical properties MOFs, hydrophobicity, nanoparticles. increase hydrophobicity causes increased biodegradability MOF, another property, depends ion environmental conditions pH. Photocleavable served for controlled degradation Generally, by optimizing these factors, desirable will obtained applications.
Язык: Английский
Процитировано
116
Materials, Год журнала: 2022, Номер 15(2), С. 503 - 503
Опубликована: Янв. 10, 2022
Due to their good magnetic properties, excellent biocompatibility, and low price, iron oxide nanoparticles (IONPs) are the most commonly used nanomaterials have been extensively explored in biomedical applications. Although IONPs can be for a variety of applications biomedicine, practical require IONP-based platforms that perform several tasks parallel. Thus, appropriate engineering integration with different classes organic inorganic materials produce multifunctional nanoplatforms functions simultaneously, allowing application broad spectrum fields. This review article summarizes fabrication current composite based on dyes, biomolecules (e.g., lipids, DNAs, aptamers, antibodies), quantum dots, noble metal NPs, stimuli-responsive polymers. We also highlight recent technological advances achieved from such integrated potential use applications, including dual-mode imaging biomolecule detection, targeted drug delivery, photodynamic therapy, chemotherapy, hyperthermia therapy.
Язык: Английский
Процитировано
106