International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3694 - 3694
Опубликована: Фев. 12, 2023
MicroRNAs
are
non-coding
RNAs
that
serve
as
regulatory
molecules
in
a
variety
of
pathways
such
inflammation,
metabolism,
homeostasis,
cell
machinery,
and
development.
With
the
progression
sequencing
methods
modern
bioinformatics
tools,
novel
roles
microRNAs
mechanisms
pathophysiological
states
continue
to
expand.
Advances
detection
have
further
enabled
larger
adoption
studies
utilizing
minimal
sample
volumes,
allowing
analysis
low-volume
biofluids,
aqueous
humor
tear
fluid.
The
reported
abundance
extracellular
these
biofluids
has
prompted
explore
their
biomarker
potential.
This
review
compiles
current
literature
reporting
human
fluid
association
with
ocular
diseases
including
dry
eye
disease,
Sjögren’s
syndrome,
keratitis,
vernal
keratoconjunctivitis,
glaucoma,
diabetic
macular
edema,
retinopathy,
well
non-ocular
diseases,
Alzheimer’s
breast
cancer.
We
also
summarize
known
shed
light
on
future
this
field.
Cancers,
Год журнала:
2022,
Номер
14(10), С. 2569 - 2569
Опубликована: Май 23, 2022
Breast
cancer
is
the
most-commonly
diagnosed
malignant
tumor
in
women
world,
as
well
first
cause
of
death
from
tumors.
The
incidence
breast
constantly
increasing
all
regions
world.
For
this
reason,
despite
progress
its
detection
and
treatment,
which
translates
into
improved
mortality
rates,
it
seems
necessary
to
look
for
new
therapeutic
methods,
predictive
prognostic
factors.
Treatment
strategies
vary
depending
on
molecular
subtype.
treatment
multidisciplinary;
includes
approaches
locoregional
therapy
(surgery
radiation
therapy)
systemic
therapy.
Systemic
therapies
include
hormone
hormone-positive
disease,
chemotherapy,
anti-HER2
HER2-positive
quite
recently,
immunotherapy.
Triple
negative
responsible
more
than
15–20%
cancers.
It
particular
research
interest
presents
a
challenge,
mainly
due
low
response
highly
invasive
nature.
Future
concepts
aim
individualize
de-escalate
escalate
based
biology
early
article
review
literature
carcinoma—a
disease
affecting
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(5), С. 2805 - 2805
Опубликована: Март 3, 2022
MicroRNAs
(miRNAs)
are
short,
noncoding,
single-stranded
RNA
molecules
that
regulate
gene
expression
at
the
post-transcriptional
level
by
binding
to
mRNAs.
miRNAs
affect
course
of
processes
fundamental
importance
for
proper
functioning
organism.
These
include
cell
division,
proliferation,
differentiation,
apoptosis
and
formation
blood
vessels.
Altered
individual
has
been
shown
in
numerous
cancers,
which
may
indicate
oncogenic
or
suppressor
potential
question.
This
paper
discusses
current
knowledge
about
possibility
using
miRNA
as
a
diagnostic
marker
target
modern
anticancer
therapies.
BioMedical Engineering OnLine,
Год журнала:
2021,
Номер
20(1)
Опубликована: Фев. 16, 2021
Over
the
last
decades,
microRNAs
(miRNAs)
have
emerged
as
important
molecules
associated
with
regulation
of
gene
expression
in
humans
and
other
organisms,
expanding
strategies
available
to
diagnose
handle
several
diseases.
This
paper
presents
a
systematic
review
literature
miRNAs
related
cancer
development
explores
main
techniques
used
quantify
these
their
limitations
screening
strategy.
The
bibliographic
research
was
conducted
using
online
databases,
PubMed,
Google
Scholar,
Web
Science,
Science
Direct
searching
terms
"microRNA
detection",
"miRNA
prostate
cancer",
cervical
cervix
breast
early
diagnosis".
Along
over
26,000
published
papers
were
reported,
252
returned
after
applying
inclusion
exclusion
criteria,
which
considered
during
this
review.
aim
study
is
identify
potential
that
may
be
useful
for
diagnosis,
notably
breast,
prostate,
cancers.
In
addition,
we
suggest
preliminary
top
20
miRNA
panel
according
relevance
respective
development.
Considering
progressive
number
new
cases
every
year
worldwide,
diagnostic
tools
critical
refine
accuracy
tests,
improving
life
expectancy
allowing
better
prognosis
affected
patients.
Cells,
Год журнала:
2024,
Номер
13(22), С. 1838 - 1838
Опубликована: Ноя. 6, 2024
Cell
survival
and
death
are
intricately
governed
by
apoptosis,
a
meticulously
controlled
programmed
cell
death.
Apoptosis
is
vital
in
facilitating
embryonic
development
maintaining
tissue
homeostasis
immunological
functioning.
It
complex
interplay
of
intrinsic
extrinsic
signaling
pathways
that
ultimately
converges
on
executing
the
apoptotic
program.
The
pathway
initiated
binding
ligands
such
as
TNF-α
Fas
to
their
respective
receptors
surface.
In
contrast,
leads
increased
permeability
outer
mitochondrial
membrane
release
apoptogenic
factors
like
cytochrome
c,
which
regulated
Bcl-2
family
proteins.
Once
activated,
these
lead
cascade
biochemical
events,
including
caspase
activation,
DNA
fragmentation,
dismantling
cellular
components.
Dysregulation
apoptosis
implicated
various
disorders,
cancer,
autoimmune
diseases,
neurodegenerative
cardiovascular
diseases.
This
article
focuses
elucidating
molecular
mechanisms
underlying
regulation,
develop
targeted
therapeutic
strategies.
Modulating
holds
immense
potential
cancer
treatment,
where
promoting
malignant
cells
could
tumor
regression.
demonstrates
targeting
providing
options
for
treating
neurological
illnesses.
safety
effectiveness
apoptosis-targeting
drugs
being
assessed
ongoing
preclinical
clinical
trials
(phase
I-III),
opening
door
more
effective
approaches
better
patient
outcomes.
The Analyst,
Год журнала:
2021,
Номер
146(12), С. 4000 - 4009
Опубликована: Янв. 1, 2021
An
electrochemical
biosensor
employing
a
gold
nanoparticles/graphene
quantum
dots/graphene
oxide
composite
modified
electrode
is
developed
for
the
multiplex
detection
of
miRNA
breast
cancer
biomarkers.
Frontiers in Immunology,
Год журнала:
2020,
Номер
11
Опубликована: Июль 14, 2020
A
balance
between
co-inhibitory
and
co-stimulatory
signals
in
the
tumor
microenvironment
(TME)
is
critical
to
suppress
development
progression,
primarily
via
maintaining
effective
immunosurveillance.
Aberrant
expression
of
immune
checkpoints
(ICs),
including
programmed
cell
death
protein
1
(PD-1),
cytotoxic
T-lymphocyte-associated
4
(CTLA-4),
T
immunoglobulin
mucin-domain
containing-3
(TIM-3),
lymphocyte-activation
gene
3
(LAG-3)
immunoreceptor
with
Ig
ITIM
domains
(TIGIT),
can
create
an
immune-subversive
environment,
which
helps
cells
evade
destruction.
Recent
studies
showed
that
epigenetic
modifications
play
roles
regulating
ICs
their
ligands
TME.
Reports
promoter
regions
genes
encoding
ICs/IC
undergo
inherent
alterations,
such
as
DNA
methylation
histone
(acetylation
methylation).
These
aberrations
significantly
contribute
transcriptomic
upregulation
ligands.
Epigenetic
therapeutics,
methyltransferase
deacetylase
inhibitors,
be
used
revert
these
anomalies
acquired
during
progression
disease.
discoveries
have
established
a
promising
therapeutic
modality
utilizing
combination
immunotherapeutic
agents
restore
physiological
profile
re-establish
potent
host
immunosurveillance
mechanisms.
In
this
review,
we
highlight
on
ICs,
focusing
development,
progression.
We
discuss
approaches
modifiers,
clinical
trials
various
cancer
settings
impact
current
future
anti-cancer
therapies.
Genes,
Год журнала:
2021,
Номер
12(3), С. 414 - 414
Опубликована: Март 13, 2021
In
the
poultry
industry,
excessive
fat
deposition
is
considered
an
undesirable
factor,
affecting
feed
efficiency,
meat
production
cost,
quality,
and
consumer’s
health.
Efforts
to
reduce
in
economically
important
animals,
such
as
chicken,
can
be
made
through
different
strategies;
including
genetic
selection,
feeding
strategies,
housing,
environmental
well
hormone
supplementation.
Recent
investigations
at
molecular
level
have
revealed
significant
role
of
transcriptional
post-transcriptional
regulatory
networks
their
interaction
on
modulating
metabolism
chickens.
At
level,
transcription
factors
are
known
regulate
expression
lipogenic
adipogenic
genes
various
signaling
pathways,
chicken
metabolism.
Alternatively,
mechanism
microRNAs
(miRNAs)
lipid
has
added
a
promising
dimension
understand
structural
functional
chicken.
Therefore,
this
review
focuses
progress
unraveling
function
genes,
factors,
more
notably
miRNAs
responsible
for
regulating
adipogenesis,
lipogenesis,
Moreover,
better
understanding
regulation
will
give
researchers
novel
insights
use
markers,
miRNAs,
selection
against
improve
efficiency
quality.
