The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

Metabolism, Год журнала: 2020, Номер 114, С. 154338 - 154338

Опубликована: Авг. 11, 2020

Язык: Английский

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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(8), С. 484 - 495

Опубликована: Июнь 15, 2021

Язык: Английский

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Targeting fibrosis: mechanisms and clinical trials

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 30, 2022

Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including liver, kidney, heart, lung. such as liver cirrhosis, idiopathic pulmonary cystic fibrosis caused substantial disease burden. Persistent abnormal activation of myofibroblasts mediated various signals, transforming growth factor, platelet-derived fibroblast growh has been recongized a major event in occurrence progression fibrosis. Although mechanisms driving organ-specific have not fully elucidated, drugs targeting these identified aberrant signals achieved potent anti-fibrotic efficacy clinical trials. In this review, we briefly introduce aetiology epidemiology several diseases, kidney cardiac Then, summarise cells (epithelial cells, endothelial immune fibroblasts) their interactions addition, also focus on signaling pathways therapeutic targets that regulate myofibroblast activation, cross-linking, metabolism, inflammation Finally, discuss based This review provides reference for further research mechanism, drug development,

Язык: Английский

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Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(3), С. 995 - 995

Опубликована: Янв. 20, 2021

Due to their unique chemical properties, per- and polyfluoroalkyl substances (PFAS) have been used extensively as industrial surfactants processing aids. While several types of PFAS voluntarily phased out by manufacturers, these chemicals continue be ecological public health concern due persistence in the environment presence living organisms. Moreover, while compounds referred “legacy” remain environment, alternative emerged replacements for legacy predecessors are now detected numerous matrices. In this review, we discuss historical uses PFAS, recent advances analytical techniques analysis compounds, fate environment. addition, evaluate current biomonitoring studies human exposure emerging examine associations with impacts, including cancer- non-cancer-related outcomes. Special focus is given short-chain perfluoroalkyl acids (PFAAs) ether-substituted, alternatives hexafluoropropylene oxide dimer acid (HFPO-DA; tradename GenX), 4,8-dioxa-3H-perfluorononanoic (DONA), 6:2 chlorinated polyfluoroethersulfonic (6:2 Cl-PFESA; F-53B).

Язык: Английский

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PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Pharmacology & Therapeutics, Год журнала: 2020, Номер 219, С. 107705 - 107705

Опубликована: Окт. 9, 2020

Язык: Английский

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Tetramethylpyrazine: A review on its mechanisms and functions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 113005 - 113005

Опубликована: Апрель 25, 2022

Ligusticum chuanxiong Hort (known as Chuanxiong in China, CX) is one of the most widely used and long-standing medicinal herbs China. Tetramethylpyrazine (TMP) an alkaloid active components CX. Over past few decades, TMP has been proven to possess several pharmacological properties. It treat a variety diseases with excellent therapeutic effects. Here, characteristics molecular mechanism recent years are reviewed, emphasis on signal-regulation TMP. This review shows that many physiological functions, including anti-oxidant, anti-inflammatory, anti-apoptosis properties; autophagy regulation; vasodilation; angiogenesis mitochondrial damage suppression; endothelial protection; reduction proliferation migration vascular smooth muscle cells; neuroprotection. At present, treating cardiovascular, nervous, digestive system conditions, cancer, other conditions achieved good curative The involves multiple targets, pathways, bidirectional regulation. is, thus, promising drug great research potential.

Язык: Английский

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PPAR-α Modulators as Current and Potential Cancer Treatments

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Март 23, 2021

Cancer is one of the leading causes mortality worldwide. PPAR modulators may hold great potential for management cancer patients. Indeed, PPARs are critical sensors and regulators lipid, they able to promote eNOS activation, regulate immunity inflammation response, affect proliferation differentiation cells. Cancer, a name given group diseases, characterized by multiple distinctive biological behaviors, including angiogenesis, abnormal cell proliferation, aerobic glycolysis, inflammation, etc. In last decade, emerging evidence has shown that PPAR-α, nuclear hormone receptor, can modulate carcinogenesis via exerting effects on or several characteristic pathological behaviors cancer. Therefore, multi-functional have substantial promise in various types therapies. This review aims consolidate functions as well discuss current applications PPAR-α agonists antagonists tackling

Язык: Английский

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Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113888 - 113888

Опубликована: Июль 24, 2021

Язык: Английский

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The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Дек. 27, 2022

Abstract Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and subsequent plasma membrane rupture. However, the remodeling mechanism that determines sensitivity to ferroptosis remains poorly understood. Here, we report previously unrecognized role for flippase solute carrier family 47 member 1 (SLC47A1) as regulator survival during ferroptosis. Among 49 phospholipid scramblases, flippases, floppases analyzed, only SLC47A1 had mRNA was selectively upregulated in multiple cancer cells exposed ferroptotic inducers. Large-scale lipidomics functional analyses revealed silencing increased RSL3- or erastin-induced favoring ACSL4-SOAT1–mediated production polyunsaturated fatty acid cholesterol esters. We identified peroxisome proliferator activated receptor alpha (PPARA) transcription factor transactivates SLC47A1. The depletion PPARA similarly sensitized induction, whereas transfection-enforced re-expression restored resistance PPARA-deficient cells. Pharmacological genetic blockade PPARA-SLC47A1 pathway anticancer activity inducer mice. These findings establish direct molecular link between transporters, which may provide metabolic targets overcoming drug resistance.

Язык: Английский

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The Many Facets of PPAR-γ Agonism in Obesity and Associated Comorbidities: Benefits, Risks, Challenges, and Future Directions

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Фев. 12, 2025

Язык: Английский

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