PeerJ,
Год журнала:
2024,
Номер
12, С. e17061 - e17061
Опубликована: Март 13, 2024
Introduction
An
increasing
number
of
studies
have
demonstrated
that
altered
microbial
diversity
and
function
(such
as
metabolites),
or
ecological
disorders,
regulate
bowel–brain
axis
involvement
in
the
pathophysiologic
processes
Alzheimer’s
disease
(AD).
The
dysregulation
microbes
their
metabolites
can
be
a
double-edged
sword
AD,
presenting
possibility
microbiome-based
treatment
options.
This
review
describes
link
between
imbalances
interactions
AD
modalities
microbiota,
potential
interventions
such
prebiotics,
probiotics,
synbiotics,
fecal
microbiota
transplantation,
dietary
complementary
therapeutic
strategies
targeting
pathogenesis
progression.
Survey
methodology
Articles
from
PubMed
china.com
on
intestinal
flora
were
summarized
to
analyze
data
conclusions
carefully
ensure
comprehensiveness,
completeness,
accuracy
this
review.
Conclusions
Regulating
gut
balance
upregulates
neurotrophic
factor
expression,
regulates
microbiota-gut-brain
(MGB)
axis,
suppresses
inflammatory
responses.
Based
emerging
research,
explored
novel
directions
for
future
research
clinical
interventions,
injecting
new
vitality
into
development.
Internal and Emergency Medicine,
Год журнала:
2023,
Номер
18(6), С. 1635 - 1646
Опубликована: Июль 4, 2023
The
intestinal
mucosa
represents
the
most
extensive
human
barrier
having
a
defense
function
against
microbial
and
food
antigens.
This
is
represented
externally
by
mucus
layer,
consisting
mainly
of
mucins,
antimicrobial
peptides,
secretory
immunoglobulin
A
(sIgA),
which
serves
as
first
interaction
with
microbiota.
Below
placed
epithelial
monolayer,
comprising
enterocytes
specialized
cells,
such
goblet
Paneth
enterochromaffin
others,
each
specific
protective,
endocrine,
or
immune
function.
layer
interacts
both
luminal
environment
underlying
lamina
propria,
where
mucosal
immunity
processes
primarily
take
place.
Specifically,
between
microbiota
an
intact
results
in
activation
tolerogenic
processes,
mediated
FOXP3+
regulatory
T
homeostasis.
Conversely,
impairment
function,
alteration
normal
composition
(dysbiosis),
imbalance
pro-
anti-inflammatory
factors
may
result
inflammation
disease.
Another
crucial
component
gut-vascular
barrier,
formed
endothelial
pericytes,
glial
regulates
passage
molecules
into
bloodstream.
aim
this
review
to
examine
various
components
assessing
their
system,
focus
on
immunological
homeostasis
inflammation.
Neural Regeneration Research,
Год журнала:
2023,
Номер
19(4), С. 833 - 845
Опубликована: Авг. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 8, 2023
Purpose
of
review
This
comprehensively
discusses
the
role
gut
microbiome
and
its
metabolites
in
health
disease
sheds
light
on
importance
a
holistic
approach
assessing
gut.
Recent
findings
The
consisting
bacteriome,
mycobiome,
archaeome,
virome
has
profound
effect
human
health.
Gut
dysbiosis
which
is
characterized
by
perturbations
microbial
population
not
only
results
gastrointestinal
(GI)
symptoms
or
conditions
but
can
also
give
rise
to
extra-GI
manifestations.
microorganisms
produce
(short-chain
fatty
acids,
trimethylamine,
hydrogen
sulfide,
methane,
so
on)
that
are
important
for
several
interkingdom
interactions
functions.
They
participate
various
host
metabolic
processes.
An
alteration
species
affect
their
respective
metabolite
concentrations
have
serious
implications.
Effective
assessment
crucial
as
it
provide
insights
into
one’s
overall
Summary
Emerging
evidence
highlights
disease.
As
implicated
GI
well
symptoms,
plays
well-being
host.
may
status
leading
more
care.
PeerJ,
Год журнала:
2024,
Номер
12, С. e17061 - e17061
Опубликована: Март 13, 2024
Introduction
An
increasing
number
of
studies
have
demonstrated
that
altered
microbial
diversity
and
function
(such
as
metabolites),
or
ecological
disorders,
regulate
bowel–brain
axis
involvement
in
the
pathophysiologic
processes
Alzheimer’s
disease
(AD).
The
dysregulation
microbes
their
metabolites
can
be
a
double-edged
sword
AD,
presenting
possibility
microbiome-based
treatment
options.
This
review
describes
link
between
imbalances
interactions
AD
modalities
microbiota,
potential
interventions
such
prebiotics,
probiotics,
synbiotics,
fecal
microbiota
transplantation,
dietary
complementary
therapeutic
strategies
targeting
pathogenesis
progression.
Survey
methodology
Articles
from
PubMed
china.com
on
intestinal
flora
were
summarized
to
analyze
data
conclusions
carefully
ensure
comprehensiveness,
completeness,
accuracy
this
review.
Conclusions
Regulating
gut
balance
upregulates
neurotrophic
factor
expression,
regulates
microbiota-gut-brain
(MGB)
axis,
suppresses
inflammatory
responses.
Based
emerging
research,
explored
novel
directions
for
future
research
clinical
interventions,
injecting
new
vitality
into
development.
