Endocannabinoids in immune regulation and immunopathologies

Immunology, Год журнала: 2021, Номер 164(2), С. 242 - 252

Опубликована: Май 30, 2021

Abstract Endocannabinoids are key bioactive components of the endocannabinoid system, and profound influence endocannabinoids on modulation immune system is being increasingly appreciated. The knowledge endocannabinoid–immune cell crosstalk will pave way to therapeutic implications modulators this pathway in autoimmune chronic inflammatory disorders. seem exert both anti‐inflammatory pro‐inflammatory effects specific contexts, based receptor engagement downstream signalling pathways involved. In review, we summarized biosynthesis, degradation two well‐studied endocannabinoids—anandamide 2‐arachidonylglycerol cells. Then, discussed these functioning major innate adaptive cells, along with choice receptors employed such interactions. Finally, outline our current involvement anandamide context inflammation, allergies, autoimmunity metabolic

Язык: Английский

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Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review

Pharmaceuticals, Год журнала: 2022, Номер 15(2), С. 210 - 210

Опубликована: Фев. 9, 2022

The use of natural products in dermatology is increasingly being pursued due to sustainability and ecological issues, as a possible way improve the therapeutic outcome chronic skin diseases, relieving burden for both patients healthcare systems. legalization cannabis by growing number countries has opened researching cannabinoids topical formulations. Cannabinoids are diverse class pharmacologically active compounds produced

Язык: Английский

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Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

Cell Death and Disease, Год журнала: 2022, Номер 13(9)

Опубликована: Сен. 21, 2022

Abstract Triple-negative breast cancer (TNBC) is a heterogeneous subtype of that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it necessary investigate factors regulating progression develop novel therapies treatment. Ferroptosis, nonapoptotic form programmed cell death characterized by accumulation iron-dependent peroxidation phospholipids, regulated cellular metabolism, redox homeostasis, various cancer-related signaling pathways. Recently, considerable progress has been made in demonstrating critical role lipid metabolism ferroptosis, indicating potential combinational therapeutic strategies In this study, drug combination screen compounds ferroptosis inducers decreasing viability, we found potent synergy CB1 antagonist rimonabant erastin/(1 S, 3 R)-RSL3 (RSL3) inhibiting growth both vitro vivo via promoting levels peroxides, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) cytosolic reactive oxygen species (ROS) production, enhancing intracellular glutathione (GSH) depletion inducing G1 cycle arrest. We identified inhibition promoted effect erastin/RSL3 on enhanced their inhibitory tumor growth. Using RNA-Seq, fatty acid analyses functional assays, stearoyl-CoA desaturase 1 (SCD1)- acyl 2 (FADS2)-dependent phosphatidylinositol kinase (PI3K)-AKT mitogen-activated protein (MAPK) pathways modulate sensitivity cells. These data demonstrate dual targeting could be promising strategy TNBC.

Язык: Английский

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Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Biomedicines, Год журнала: 2023, Номер 11(8), С. 2323 - 2323

Опубликована: Авг. 21, 2023

The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of bioactive endocannabinoid. As hypothetical afterthought, this proposed to hold general relevance usage products based on Cannabis sativa L. later juxtaposed polypharmacy pertaining full-spectrum medicinal exerting an overall higher effect than single compounds. Since emergence term, discussion its pharmacological foundation and has been ongoing. Advocates suggest that is reason many patients experience better from products. Critics state unfounded used primarily for marketing purposes industry. This scoping review aims segregate primary research claiming as well disputing existence perspective. literature topic infancy. Existing clinical studies are simplistic methodologies show contradictory findings, with data mostly relying anecdotal real-world evidence. We propose explained by traditional terms other plant-based (e.g., synergistic interactions bioenhancement).

Язык: Английский

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Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review

Behavioural Neurology, Год журнала: 2023, Номер 2023, С. 1 - 17

Опубликована: Окт. 12, 2023

Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's which present major healthcare concerns on a worldwide scale. Despite lack available therapies, been shown to possess variety pharmacological effects preclinical clinical studies, making it an intriguing competitor. review brings together most recent findings endocannabinoid neurotransmitter systems, as well anti-inflammatory pathways, that underlie CBD's modes action. Synthesized efficacy safety assessments range illnesses are included, covering human trials, vitro animal models. The investigation includes how could protect neurons, control neuroinflammation, fend off oxidative stress, manage neuronal excitability. study emphasizes existing studies future possibilities research, addressing research issues such regulatory complications contradicting results, advocates further ideal dose methodologies. By emphasizing improve patient well-being, this presents revised viewpoint suitability intervention illnesses.

Язык: Английский

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Exploring causal mechanisms of psychosis risk

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 162, С. 105699 - 105699

Опубликована: Май 6, 2024

Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous syntheses have classified these according their strength association with psychosis. In this critical review we appraise the distinct overlapping mechanisms 25 key environmental psychosis, link mechanistic pathways that may contribute neurochemical alterations hypothesised underlie psychotic symptoms. We then discuss implications our findings future research, specifically considering interactions between factors, exploring universal subgroup-specific improving understanding temporality dynamics, standardising operationalisation measurement developing interventions targeting factors.

Язык: Английский

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Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Дек. 22, 2021

Inflammatory bowel disease (IBD) is a general term used to describe group of chronic inflammatory conditions the gastrointestinal tract unknown etiology, including two primary forms: Crohn's (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS) plays an important role in modulating many physiological processes intestinal homeostasis, modulation motility, visceral sensation, or immunomodulation inflammation IBD. It consists cannabinoid receptors (CB1 CB2), transporters for cellular uptake ligands, endogenous bioactive lipids (Anandamide 2-arachidonoylglycerol), enzymes responsible their synthesis degradation (fatty acid amide hydrolase monoacylglycerol lipase), manipulation which through agonists antagonists system, shows potential therapeutic ECS disease. This review summarizes components on inflammation, suggesting advantages cannabinoid-based therapies

Язык: Английский

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Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development

Journal of Medicinal Chemistry, Год журнала: 2020, Номер 64(1), С. 123 - 149

Опубликована: Дек. 31, 2020

The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors enzymes responsible for synthesis degradation. Over the past 2 decades, significant advances toward developing drugs positron emission tomography (PET) tracers targeting different components ECS have been made. Herein, we summarized recent development PET imaging 1 (CB1R) (CB2R) as well key monoacylglycerol lipase (MAGL) fatty acid amide hydrolase (FAAH), particularly focusing on neuroimaging applications. State-of-the-art will be reviewed including their chemical design, pharmacological properties, radiolabeling, preclinical human imaging. In addition, this review addresses current challenges biomarker highlights important role ligands to study disease pathophysiology facilitate drug discovery.

Язык: Английский

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New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1

Journal of Hazardous Materials, Год журнала: 2021, Номер 418, С. 126100 - 126100

Опубликована: Май 24, 2021

Язык: Английский

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Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019

Heliyon, Год журнала: 2021, Номер 7(2), С. e05990 - e05990

Опубликована: Фев. 1, 2021

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing public health emergency. The pathogenesis and complications advanced with infection mainly involve immune-inflammatory cascade. Therefore, the therapeutic strategy relies on immune modulation, reducing infectivity inflammation. Given interplay of axis, natural products received attention for preventive usage in COVID-19 due to their potent antiviral anti-immunomodulatory activities. Recently, Echinacea preparations, particularly E. purpurea, have been suggested be important agent useful modulating virus entry, internalization replication. In principle, response resultant inflammatory process are elimination infection, but may a significant impact SARS-CoV-2 play role clinical spectrum COVID-19. Considering pharmacological effects, potential, molecular mechanisms Echinacea, we hypothesize that it could reasonably possible candidate targeting immunity, inflammation recent recognition cannabinoid-2 (CB2) receptors peroxisome proliferator-activated receptor gamma (PPARγ) mediated bioactive components make them notable immunomodulatory, anti-inflammatory agent. plausible reason our hypothesis presence numerous agents different parts plants synergistically exert polypharmacological actions regulating axis Our proposition scientifically contemplate perspective prospect potential limit severity progression disease. Based infections, relative safety humans, further studies evidence-based approach needed. We do hope immunomodulation prevention treatment

Язык: Английский

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