Cannabis sativa Cannabinoids as Functional Ingredients in Snack Foods—Historical and Developmental Aspects

Plants, Год журнала: 2022, Номер 11(23), С. 3330 - 3330

Опубликована: Дек. 1, 2022

The published health benefits of Cannabis sativa has caught the attention health-conscious consumers and food industry. Historically, seeds have long been utilized as a source currently there is an increasing number edibles on market that contain cannabis. Cannabinoids include psychoactive constituent, delta-9-tetrahydrocannabinol (THC), non-psychoactive cannabidiol (CBD) are both compounds interest in sativa. This paper looks at distribution nutrients phytocannabinoids low-THC sativa, historical uses hemp, cannabis edibles, possible side-effects concerns related to edibles. Several authors pointed out even though use considered safe, it important mention their any its consumption negatively influence consumer acceptance Such risks unintentional overdose by adults accidental ingestion children adolescents resulting serious adverse effects. Therefore, should be specifically packaged labelled differentiate them from known similar non-cannabis so that, together with tamperproof packaging, these measures reduce appeal products children.

Язык: Английский

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An Individuality of Response to Cannabinoids: Challenges in Safety and Efficacy of Cannabis Products

Molecules, Год журнала: 2023, Номер 28(6), С. 2791 - 2791

Опубликована: Март 20, 2023

Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral consumption of cannabis transports much less hazardous chemicals than smoking. Nevertheless, the response to is biphasically dose-dependent (hormesis; low-dose stimulation high-dose inhibition) wide individuality responses. Thus, exact same dose preparation may be beneficial for some but toxic others. purpose this review highlight concept individual variations cannabinoids, which leads challenge establishing standard safe doses products general population. mechanisms actions, acute chronic toxicities, factors affecting responses updated. Based on literature review, we found that depends exposure (delivery route, duration, frequency, interactions food drugs), (age, sex), susceptibility (genetic polymorphisms cannabinoid receptor gene, N-acylethanolamine-hydrolyzing enzymes, THC-metabolizing epigenetic regulations). Owing responses, safest way use cannabis-containing start low, go slow, stay low.

Язык: Английский

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Phytocannabinoids in the Pharmacotherapy of Psoriasis

Molecules, Год журнала: 2023, Номер 28(3), С. 1192 - 1192

Опубликована: Янв. 25, 2023

Phytocannabinoids are naturally occurring compounds, the main source of which is Cannabis sativa L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels modify effectiveness transcription factor responsible for biosynthesis antioxidants lead to oxidative stress its consequences. Due modification redox balance inflammation, phytocannabinoids used in treatment various diseases, including autoimmune dermatoses, such as atopic dermatitis psoriasis. Psoriasis one most common unknown etiology. A disturbed a shift towards oxidation leads stress, resulting modifications, mainly lipids proteins, prolonged activation immune cells increased generation cytokines, chronic inflammation. Given biological activity phytocannabinoids, have become focus research components pharmacotherapy Beneficial effects were shown by representatives but effect cannabidiol (CBD) on skin (in vitro ex vivo) blood from patients psoriasis vulgaris psoriatic arthritis has been often evaluated recent years.

Язык: Английский

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Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies

Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 155 - 155

Опубликована: Янв. 20, 2023

The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD extracted from Cannabis sativa, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for uses anti-inflammatory, antioxidant, anticonvulsant, anxiolytic potential. molecular mechanisms involved in CBD’s biological are not limited interaction with classical cannabinoid receptors, exerting anti-inflammatory or pain-relief effects. Several pieces evidence demonstrate that interacts other receptors cellular signaling cascades, which further support therapeutic potential beyond pain management. In this review, we take a closer look at application context cancer, neurodegeneration, autoimmune diseases.

Язык: Английский

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Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12738 - 12738

Опубликована: Ноя. 27, 2024

Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) cannabidiol (CBD). Cannabinoids have an effect on endocannabinoid system (ECS), a cellular communication network, are, hence, widely studied for medical applications. Epidiolex®, 99% pure oral CBD extract, has been approved by FDA treatment of epilepsy. Nabiximols (Sativex) is oromucosal spray containing equal volume THC CBD, it commonly used as add-on unresponsive spasticity in multiple sclerosis (MS) patients. Several vitro vivo studies also shown that cannabinoids can be to treat various types cancer, such melanoma brain glioblastoma; first positive clinical trials anticancer THC:CBD blend temozolomide (TMZ) highly invasive cancer are very promising. The exert their properties investigations induction cell death, mainly apoptosis cytotoxic autophagy, inhibition proliferation. In several studies, found induce tumor regression inhibit angiogenic mechanisms vivo, well two low-numbered epidemiological studies. They exhibit antiviral effects inhibiting ACE2 transcription, blocking viral replication fusion, acting agents; indeed, prior consumption (a study 93,565 persons Chicago) associated much lower incidence SARS-CoV-2 infections. It postulated cannabis extracts many other diseases systemic lupus erythematosus, type 1 diabetes, or neurological disorders, e.g., Alzheimer’s disease. aim this review outline current state knowledge regarding currently medicinal preparations derived from C. selected diseases, present latest research potential applications its secondary metabolites.

Язык: Английский

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