Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review)

Experimental and Therapeutic Medicine, Год журнала: 2022, Номер 23(6)

Опубликована: Май 6, 2022

Myocardial infarction is one of the primary causes mortality in patients with coronary heart disease worldwide. Early treatment acute myocardial restores blood supply ischemic myocardium and decreases risk. However, when interrupted recovered within a certain period time, it more serious damage to original myocardium; this known as ischemia/reperfusion injury (MIRI). The pathophysiological mechanisms leading MIRI are associated oxidative stress, intracellular calcium overload, energy metabolism disorder, apoptosis, endoplasmic reticulum autophagy, pyroptosis, necroptosis ferroptosis. These interplay another directly or indirectly lead aggravation effect. In past, apoptosis autophagy have attracted attention but ferroptosis also serve key roles. mechanism has not been fully elucidated. present study reviews underlying MIRI. Based on current understanding MIRI, association between cell death‑associated signaling pathways were elaborated, providing direction for investigation novel targets clinical treatment.

Язык: Английский

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Oxidative Stress and Diseases Associated with High-Altitude Exposure

Antioxidants, Год журнала: 2022, Номер 11(2), С. 267 - 267

Опубликована: Янв. 28, 2022

Several diseases associated with high-altitude exposure affect unacclimated individuals. These include acute mountain sickness (AMS), cerebral edema (HACE), pulmonary (HAPE), chronic (CMS), and, notably, hypertension (HAPH), which can eventually lead to right ventricle hypertrophy and heart failure. The development of these pathologies involves different molecules molecular pathways that might be related oxidative stress. Studies have shown acute, intermittent, hypobaric hypoxia induce stress, causing alterations cellular components (lipids, proteins, DNA). Therefore, the aim this review is discuss involved in diseases. In summary, all are as indicated by increases malondialdehyde (MDA) biomarker decreases superoxide dismutase (SOD) glutathione peroxidase (GPx) antioxidant activity. addition, CMS, levels 8-iso-PGF2α H2O2 increased, evidence strongly indicates an increase Nox4 activity HAPH. treatments seem a promising approach mitigating pathologies.

Язык: Английский

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The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury

International Immunopharmacology, Год журнала: 2023, Номер 123, С. 110714 - 110714

Опубликована: Июль 29, 2023

Язык: Английский

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Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia Exposure

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(20), С. 12656 - 12656

Опубликована: Окт. 21, 2022

Exposure to high altitudes generates a decrease in the partial pressure of oxygen, triggering hypobaric hypoxic condition. This condition produces pathophysiologic alterations an organism. In lung, one principal responses hypoxia is development pulmonary vasoconstriction (HPV), which improves gas exchange. However, when HPV exacerbated, it induces high-altitude hypertension (HAPH). Another important illness edema (HAPE), occurs under acute exposure. Several studies have shown that inflammatory processes are activated illnesses, highlighting importance crosstalk between and inflammation. The aim this review determine pathways involved hypoxia, investigate key role inflammation lung pathologies, such as HAPH HAPE, summarize different anti-inflammatory treatment approaches for these illnesses. conclusion, both HAPE show increase cell infiltration (macrophages neutrophils), cytokine levels (IL-6, TNF-α IL-1β), chemokine (MCP-1), adhesion molecule (ICAM-1 VCAM-1), treatments (decreasing all components mentioned above) seem be promising mitigation strategies treating pathologies associated with

Язык: Английский

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Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish

Environmental Science & Technology, Год журнала: 2022, Номер 56(12), С. 8438 - 8448

Опубликована: Июнь 2, 2022

Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is widely used during industrial processes, though little known about its toxicity, particularly to early life stage organisms that are generally sensitive xenobiotic exposure. Here, following exposure concentrations 0.01, 0.1, 1, 10, and 100 μg/L PFOSA, transcriptional, morphological, physiological, biochemical assays were evaluate the potential effects on aquatic organisms. The top Tox functions in exposed zebrafish related cardiac diseases predicted by Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway, Ingenuity Pathway Analysis (IPA) analysis. Consistent with impacts transcriptional changes, abnormal morphology, disordered heartbeat signals, as well reduced heart rate output observed or PFOSA. Furthermore, these PFOSA-induced either prevented alleviated supplementation an aryl hydrocarbon receptor (AHR) antagonist ahr2-morpholino knock-down, uncovering seminal role AHR cardiotoxicity. Our results provide first evidence fish PFOSA can impair proper development function raises concern for analogues natural environment.

Язык: Английский

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Oxidative Stress and Antioxidative Therapy in Pulmonary Arterial Hypertension

Molecules, Год журнала: 2022, Номер 27(12), С. 3724 - 3724

Опубликована: Июнь 9, 2022

Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase in pulmonary artery pressure, followed right ventricular hypertrophy and subsequently heart failure. The underlying mechanism of PAH includes endothelial dysfunction intimal smooth muscle proliferation. Numerous studies have shown that oxidative stress critical the pathophysiology involves changes reactive oxygen species (ROS), nitrogen (RNS), nitric oxide (NO) signaling pathways. Disrupted ROS NO pathways cause proliferation cells (PAECs) vascular (PASMCs), resulting DNA damage, metabolic abnormalities, remodeling. Antioxidant treatment has become main area research for PAH. This review mainly introduces pathogenesis antioxidative therapies explains why targeting valid strategy treatment.

Язык: Английский

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The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure

Medicina, Год журнала: 2024, Номер 60(5), С. 760 - 760

Опубликована: Май 2, 2024

Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) its active form, brain-type (BNP), in simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good such as peptides fail to predict all risks associated with due diversity of mechanisms involved. pathophysiology is determined by numerous factors, including oxidative stress, inflammation, neuroendocrine activation, pathological angiogenesis, changes apoptotic pathways, fibrosis vascular remodeling. High readmission mortality rates prompt search new markers diagnosis, prognosis treatment HF. Oxidative-stress-mediated inflammation plays crucial role development subsequent failing heart provides insight into this complex mechanism. Oxidative stress inflammatory appear be promising diagnostic prognostic tool patients This systematic review an overview current knowledge about parameters

Язык: Английский

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Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 486, С. 116917 - 116917

Опубликована: Март 28, 2024

Язык: Английский

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Rhodiola crenulate alleviates hypobaric hypoxia-induced brain injury via adjusting NF-κB/NLRP3-mediated inflammation

Phytomedicine, Год журнала: 2022, Номер 103, С. 154240 - 154240

Опубликована: Июнь 4, 2022

Язык: Английский

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Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Science China Life Sciences, Год журнала: 2022, Номер 65(10), С. 2093 - 2113

Опубликована: Март 14, 2022

Язык: Английский

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