Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1256, P. 124552 - 124552
Published: March 3, 2025
Language: Английский
Experimental and Therapeutic Medicine, Journal Year: 2022, Volume and Issue: 23(6)
Published: May 6, 2022
Myocardial infarction is one of the primary causes mortality in patients with coronary heart disease worldwide. Early treatment acute myocardial restores blood supply ischemic myocardium and decreases risk. However, when interrupted recovered within a certain period time, it more serious damage to original myocardium; this known as ischemia/reperfusion injury (MIRI). The pathophysiological mechanisms leading MIRI are associated oxidative stress, intracellular calcium overload, energy metabolism disorder, apoptosis, endoplasmic reticulum autophagy, pyroptosis, necroptosis ferroptosis. These interplay another directly or indirectly lead aggravation effect. In past, apoptosis autophagy have attracted attention but ferroptosis also serve key roles. mechanism has not been fully elucidated. present study reviews underlying MIRI. Based on current understanding MIRI, association between cell death‑associated signaling pathways were elaborated, providing direction for investigation novel targets clinical treatment.
Language: Английский
Citations
144
Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 267 - 267
Published: Jan. 28, 2022
Several diseases associated with high-altitude exposure affect unacclimated individuals. These include acute mountain sickness (AMS), cerebral edema (HACE), pulmonary (HAPE), chronic (CMS), and, notably, hypertension (HAPH), which can eventually lead to right ventricle hypertrophy and heart failure. The development of these pathologies involves different molecules molecular pathways that might be related oxidative stress. Studies have shown acute, intermittent, hypobaric hypoxia induce stress, causing alterations cellular components (lipids, proteins, DNA). Therefore, the aim this review is discuss involved in diseases. In summary, all are as indicated by increases malondialdehyde (MDA) biomarker decreases superoxide dismutase (SOD) glutathione peroxidase (GPx) antioxidant activity. addition, CMS, levels 8-iso-PGF2α H2O2 increased, evidence strongly indicates an increase Nox4 activity HAPH. treatments seem a promising approach mitigating pathologies.
Language: Английский
Citations
92
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 123, P. 110714 - 110714
Published: July 29, 2023
Language: Английский
Citations
56
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12656 - 12656
Published: Oct. 21, 2022
Exposure to high altitudes generates a decrease in the partial pressure of oxygen, triggering hypobaric hypoxic condition. This condition produces pathophysiologic alterations an organism. In lung, one principal responses hypoxia is development pulmonary vasoconstriction (HPV), which improves gas exchange. However, when HPV exacerbated, it induces high-altitude hypertension (HAPH). Another important illness edema (HAPE), occurs under acute exposure. Several studies have shown that inflammatory processes are activated illnesses, highlighting importance crosstalk between and inflammation. The aim this review determine pathways involved hypoxia, investigate key role inflammation lung pathologies, such as HAPH HAPE, summarize different anti-inflammatory treatment approaches for these illnesses. conclusion, both HAPE show increase cell infiltration (macrophages neutrophils), cytokine levels (IL-6, TNF-α IL-1β), chemokine (MCP-1), adhesion molecule (ICAM-1 VCAM-1), treatments (decreasing all components mentioned above) seem be promising mitigation strategies treating pathologies associated with
Language: Английский
Citations
57
Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(12), P. 8438 - 8448
Published: June 2, 2022
Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is widely used during industrial processes, though little known about its toxicity, particularly to early life stage organisms that are generally sensitive xenobiotic exposure. Here, following exposure concentrations 0.01, 0.1, 1, 10, and 100 μg/L PFOSA, transcriptional, morphological, physiological, biochemical assays were evaluate the potential effects on aquatic organisms. The top Tox functions in exposed zebrafish related cardiac diseases predicted by Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway, Ingenuity Pathway Analysis (IPA) analysis. Consistent with impacts transcriptional changes, abnormal morphology, disordered heartbeat signals, as well reduced heart rate output observed or PFOSA. Furthermore, these PFOSA-induced either prevented alleviated supplementation an aryl hydrocarbon receptor (AHR) antagonist ahr2-morpholino knock-down, uncovering seminal role AHR cardiotoxicity. Our results provide first evidence fish PFOSA can impair proper development function raises concern for analogues natural environment.
Language: Английский
Citations
47
Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3724 - 3724
Published: June 9, 2022
Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase in pulmonary artery pressure, followed right ventricular hypertrophy and subsequently heart failure. The underlying mechanism of PAH includes endothelial dysfunction intimal smooth muscle proliferation. Numerous studies have shown that oxidative stress critical the pathophysiology involves changes reactive oxygen species (ROS), nitrogen (RNS), nitric oxide (NO) signaling pathways. Disrupted ROS NO pathways cause proliferation cells (PAECs) vascular (PASMCs), resulting DNA damage, metabolic abnormalities, remodeling. Antioxidant treatment has become main area research for PAH. This review mainly introduces pathogenesis antioxidative therapies explains why targeting valid strategy treatment.
Language: Английский
Citations
43
Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 760 - 760
Published: May 2, 2024
Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) its active form, brain-type (BNP), in simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good such as peptides fail to predict all risks associated with due diversity of mechanisms involved. pathophysiology is determined by numerous factors, including oxidative stress, inflammation, neuroendocrine activation, pathological angiogenesis, changes apoptotic pathways, fibrosis vascular remodeling. High readmission mortality rates prompt search new markers diagnosis, prognosis treatment HF. Oxidative-stress-mediated inflammation plays crucial role development subsequent failing heart provides insight into this complex mechanism. Oxidative stress inflammatory appear be promising diagnostic prognostic tool patients This systematic review an overview current knowledge about parameters
Language: Английский
Citations
10
Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 486, P. 116917 - 116917
Published: March 28, 2024
Language: Английский
Citations
9
Phytomedicine, Journal Year: 2022, Volume and Issue: 103, P. 154240 - 154240
Published: June 4, 2022
Language: Английский
Citations
35
Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(10), P. 2093 - 2113
Published: March 14, 2022
Language: Английский
Citations
32