High altitude hypoxia and oxidative stress: The new hope brought by free radical scavengers

Life Sciences, Год журнала: 2023, Номер 336, С. 122319 - 122319

Опубликована: Ноя. 29, 2023

Язык: Английский

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Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts

Current Problems in Cardiology, Год журнала: 2023, Номер 49(1), С. 102052 - 102052

Опубликована: Авг. 26, 2023

Язык: Английский

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Gut Microbiome-Targeted Modulations Regulate Metabolic Profiles and Alleviate Altitude-Related Cardiac Hypertrophy in Rats

Microbiology Spectrum, Год журнала: 2022, Номер 10(1)

Опубликована: Фев. 9, 2022

Evidence suggests that gut microbiome changes upon hypobaric hypoxia exposure; however, it remains elusive whether this change is a merely derivational reflection of host physiological alteration, or synergizes to exacerbate high-altitude diseases. We intervened in the rat model prolonged challenge and found intervention could alleviate symptoms pathological cardiac hypertrophy, microbial dysbiosis, metabolic disruptions certain metabolites plasma induced by hypoxia.

Язык: Английский

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Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 151, С. 113191 - 113191

Опубликована: Май 25, 2022

Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic drugs approaches are needed urgently. Baicalein baicalin, the active compounds of traditional Chinese medicine, Scutellaria baicalensis Georgi, exhibit wide range pharmacological activities. Numerous studies involving in vitro vivo models PH have revealed that treatment with baicalin baicalein may be effective. This review summarizes potential mechanisms driving beneficial effects on PH, including anti-inflammatory response, inhibition pulmonary smooth muscle cell proliferation endothelial-to-mesenchymal transformation, stabilization extracellular matrix, mitigation oxidative stress. The pharmacokinetics these also been reviewed. warrants their continued study as natural treatments PH.

Язык: Английский

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Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway

International Immunopharmacology, Год журнала: 2023, Номер 121, С. 110423 - 110423

Опубликована: Июнь 17, 2023

Язык: Английский

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SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway

APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1663 - 1678

Опубликована: Апрель 27, 2024

Язык: Английский

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Baicalin attenuates acute skin damage induced by ultraviolet B via inhibiting pyroptosis

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 256, С. 112937 - 112937

Опубликована: Май 9, 2024

Язык: Английский

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Potential therapeutic effects of traditional Chinese medicine in acute mountain sickness: pathogenesis, mechanisms and future directions

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июнь 4, 2024

Background and objectives Acute mountain sickness (AMS) is a pathology with different symptoms in which the organism not adapted to environment that occurs under special of high altitude. Its main mechanism organism’s tissue damage caused by acute hypobaric hypoxia. Traditional Chinese medicine (TCM) theory focuses on holistic concept. TCM has made remarkable achievements treatment many sicknesses. This review outlines pathogenesis AMS modern traditional medicine, progress animal models AMS, summarizes therapeutic effects AMS. Methods Using keywords “traditional medicine,” “herbal “acute sickness,” “high-altitude pulmonary edema,” cerebral hypoxia,” “high-altitude,” all relevant literature published up November 2023 were collected from Scopus, Web Science, PubMed, China National Knowledge Infrastructure databases, key information was analyzed. Results We systematically summarised hypoxia tissues organism, study methodology for establishment an model retrieved 18 proprietary medicines clinical The principle mainly invigorating qi, activating blood removing stasis. components botanical drugs include salidroside, ginsenoside Rg1, tetrahydrocurcumin. action through regulation HIF-1α/NF-κB signaling pathway, inhibition inflammatory response oxidative stress, enhancement energy metabolism. Conclusion unclear. Still, formulas have been used treat multifaceted interventions, such as compound danshen drip pills, Huangqi Baihe granules, Rg1. These generally exert anti-AMS pharmacological inhibiting expression VEGF, concentration MDA pro-inflammatory factors, down-regulating NF-κB/NLRP3 promoting SOD Na + -K -ATPase activities, attenuates hypoxia-induced injury. comprehensively analyses application makes suggestions more in-depth studies future, aiming provide some ideas insights subsequent studies.

Язык: Английский

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Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension

Molecules, Год журнала: 2022, Номер 27(10), С. 3327 - 3327

Опубликована: Май 22, 2022

Cannabidiol (CBD) is a plant-derived compound with antioxidant and anti-inflammatory properties. Pulmonary hypertension (PH) still an incurable disease. CBD has been suggested to ameliorate monocrotaline (MCT)-induced PH, including reduction in right ventricular systolic pressure (RVSP), vasorelaxant effect on pulmonary arteries decrease the white blood cell count. The aim of our study was investigate chronic administration (10 mg/kg daily for 21 days) parameters oxidative stress inflammation lungs rats MCT-induced PH. In we found total capacity (TAC) glutathione level (GSH), increase inflammatory parameters, e.g., tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), nuclear kappa B (NF-κB), monocyte chemoattractant protein-1 (MCP-1), cluster differentiation 68 (CD68), overexpression cannabinoid receptors type 1 2 (CB1-Rs, CB2-Rs). Administration increased TAC GSH concentrations, reductase (GSR) activity, decreased CB1-Rs expression levels mediators such as TNF-α, IL -1β, NF-κB, MCP-1 CD68. conclusion, effects may act adjuvant therapy but further detailed preclinical clinical studies are recommended confirm promising results.

Язык: Английский

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AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(11), С. 6205 - 6205

Опубликована: Июнь 1, 2022

Hypoxic pulmonary hypertension (HPH) is characterized by sustained elevation of artery pressure produced vasoconstriction and hyperproliferative remodeling the subsequent right ventricular hypertrophy (RVH). The search for therapeutic targets cardiovascular pathophysiology has extended in many directions. However, studies focused on mitigating high-altitude (HAPH) have been rare. Because AMP-activated protein kinase (AMPK) involved metabolic pathology, AMPK often studied as a potential target. best sensor cellular energy that can also restore homeostasis. implicated other pathways with vasculoprotective effects. Notably, stress increases intracellular ADP/ATP or AMP/ATP ratio, activation restores ATP levels activating energy-producing catabolic inhibiting energy-consuming anabolic pathways, such cell growth proliferation promoting protection. Thus, plays an important role antiproliferative, antihypertrophic antioxidant HPH. contradictory roles HPH development. This review describes main findings related to participation its It extrapolates known functions discuss less-studied HAPH context.

Язык: Английский

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