Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 17, 2024
Osteoarthritis
(OA)
is
a
degenerative
disease
with
high
incidence
worldwide.
Most
affected
patients
do
not
exhibit
obvious
discomfort
symptoms
or
imaging
findings
until
OA
progresses,
leading
to
irreversible
destruction
of
articular
cartilage
and
bone.
Therefore,
developing
new
diagnostic
biomarkers
that
can
reflect
injury
crucial
for
the
early
diagnosis
OA.
This
study
aims
explore
related
immune
microenvironment
OA,
providing
research
direction
identification
risk
factors
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Фев. 3, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
inflammatory
disease
characterized
by
inflammation
of
the
synovial
tissue
and
joint
bone
destruction,
often
leading
to
significant
disability.
The
main
pathological
manifestation
deformity
in
RA
patients
which
occurs
due
differentiation
proliferation
osteoclasts.
transcription
factor
nuclear
factor-activated
T
cell
1
(NFATc1)
plays
crucial
role
this
process.
regulation
NFATc1
osteoclast
influenced
three
factors.
Firstly,
activated
through
upstream
kappa-B
ligand
(RANKL)/RANK
signaling
pathway.
Secondly,
Ca
2+
-related
co-stimulatory
pathway
amplifies
activity.
Finally,
negative
action
cytokines
such
as
B-cell
Lymphoma
6
(Bcl-6),
interferon
regulatory
8
(IRF8),
MAF
basic
leucine
zipper
B
(MafB),
LIM
homeobox
2
(Lhx2).
These
phases
collectively
govern
subsequently
affect
expression
downstream
target
genes
including
TRAF6
NF-κB.
Ultimately,
intricate
network
mediates
differentiation,
fusion,
degradation
both
organic
inorganic
components
matrix.
This
review
provides
comprehensive
summary
recent
advances
understanding
mechanism
context
RA-related
destruction
discusses
potential
therapeutic
agents
that
NFATc1,
with
aim
offering
valuable
insights
for
future
research
field
RA.
To
assess
their
RA,
we
conducted
drug-like
analysis
drugs
precise
structures.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Formononetin
(FMN)
is
a
common
natural
metabolite
that
can
be
extracted
and
isolated
from
some
botanical
drugs.
In
recent
years,
FMN
has
garnered
increasing
attention
due
to
its
beneficial
biological
activities.
this
paper,
we
systematically
summarize
the
sources
of
provide
comprehensive
review
pharmacological
activities
molecular
mechanisms,
co-administration,
toxicity,
derivatives,
drug
delivery
systems
in
last
5
years.
The
study
results
found
wide
range
neurological
disorders,
organ
damage
cancer,
showing
great
potential
for
clinical
application
broad
prospects.
Researchers
are
exploring
various
types
systems,
including
nanoparticle
carriers,
ligand
modifications
polymer
microspheres.
These
advanced
enhance
stability
FMN,
prolong
release
time
vivo
,
improve
targeting,
thereby
optimizing
therapeutic
efficacy
reducing
side
effects,
greatly
improving
bioavailability.
conclusion,
with
considerable
research
value,
diverse
make
it
promising
candidate
development
medical
research.
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 22, 2024
Abstract
Knee
osteoarthritis
(KOA)
is
a
prevalent
degenerative
joint
disease
that
primarily
managed
by
improving
the
destroyed
cartilage
and
reversing
subchondral
bone
remodeling.
Total
glucosides
of
white
paeony
(TGP)
capsule
contains
extracts
from
peony
root
has
been
shown
to
have
various
pharmacological
effects,
but
its
role
in
KOA
still
requires
comprehensive
evaluation.
In
this
study,
we
aimed
investigate
protective
effect
TGP
on
knee
bone,
as
well
elucidate
underlying
molecular
mechanisms.
The
progression
was
evaluated
destabilization
medial
meniscus
(DMM)‐induced
model
mouse
interleukin
(IL)‐1β‐induced
primary
chondrocytes.
vivo
vitro
experiments
demonstrated
had
cartilage.
Treatment
with
could
induce
synthesis
critical
elements
extracellular
matrix
downregulate
degrading
enzymes
matrix.
Regarding
mechanisms,
inhibited
phosphorylation
nuclear
translocation
p65
regulating
factor‐kappa
B
(NF‐κB)
signaling
pathway.
addition,
reduce
secretion
IL‐1β,
IL‐6,
tumor
necrosis
factor‐α
(TNF‐α).
Moreover,
it
sustained
coupled
remodeling
through
regulation
OPG/RANKL/RANK
conclusion,
may
protect
articular
downregulating
NF‐κB
pathway
support
DMM‐induced
mouse,
suggesting
new
therapeutic
potential
for
treatment.
