BMC Ecology and Evolution,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 24, 2025
Abstract
The
pace
of
life
(POL)
is
shaped
by
a
complex
interplay
between
genetic
and
environmental
factors,
influencing
growth,
maturation,
lifespan
across
species.
Hippo
signaling
pathway,
key
regulator
organ
size
cellular
homeostasis,
has
emerged
as
central
integrator
cues
that
modulate
POL
traits.
In
this
review,
we
explore
how
the
pathway
links
factors—such
temperature
fluctuations
dietary
energy
availability—to
molecular
mechanisms
governing
metabolic
balance,
hormonal
signaling,
reproductive
timing.
Specifically,
highlight
regulatory
interactions
sensors
(AMPK,
mTOR,
SIRT1
DLK1-Notch),
well
signals
(IGF-1,
kisspeptin,
leptin,
cortisol,
thyroid
sex
steroids),
which
together
orchestrate
life-history
traits,
including
growth
rates,
sexual
with
particular
emphasis
on
their
role
in
Furthermore,
consider
its
potential
coordinator
POL-related
processes,
such
telomere
dynamics
epigenetic
mechanisms,
within
broader
network.
By
integrating
insights
from
biology
eco-evolutionary
perspectives,
propose
future
directions
to
dissect
pathway’s
regulation
taxa.
Understanding
these
will
provide
new
perspectives
organisms
adaptively
adjust
strategies
response
variability.
Cells,
Год журнала:
2024,
Номер
13(5), С. 390 - 390
Опубликована: Фев. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Abstract
Converting
multiomics
datasets
into
gene
sets
facilitates
data
integration
that
leads
to
knowledge
discovery.
Although
there
are
tools
developed
analyze
sets,
only
a
few
offer
the
management
of
from
multiple
sources.
GeneSetCart
is
an
interactive
web-based
platform
enables
investigators
gather
various
sources;
augment
these
with
gene–gene
coexpression
correlations
and
protein–protein
interactions;
perform
set
operations
on
such
as
union,
consensus,
intersection;
visualize
all
in
one
place.
supports
upload
single
or
well
fetching
by
searching
PubMed
for
genes
comentioned
terms
publications.
Venn
diagrams,
heatmaps,
Uniform
Manifold
Approximation
Projection
(UMAP)
plots,
SuperVenn
UpSet
plots
can
session
summarize
similarity
overlap
among
sets.
Users
also
enrichment
analysis
their
assembled
external
tools.
All
be
saved
user
account
reanalysis
sharing
collaborators.
has
library
crossing
feature
created
several
National
Institutes
Health
Common
Fund
programs.
For
top
overlapping
pairs
programs,
large
language
model
(LLM)
prompted
propose
possible
reasons
high
overlap.
Using
this
feature,
two
use
cases
presented.
In
addition,
users
produce
publication-ready
reports
uploaded
Text
supplemented
LLM.
Overall,
useful
resource
enabling
biologists
without
programming
expertise
facilitate
hypothesis
generation.
BMC Ecology and Evolution,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 24, 2025
Abstract
The
pace
of
life
(POL)
is
shaped
by
a
complex
interplay
between
genetic
and
environmental
factors,
influencing
growth,
maturation,
lifespan
across
species.
Hippo
signaling
pathway,
key
regulator
organ
size
cellular
homeostasis,
has
emerged
as
central
integrator
cues
that
modulate
POL
traits.
In
this
review,
we
explore
how
the
pathway
links
factors—such
temperature
fluctuations
dietary
energy
availability—to
molecular
mechanisms
governing
metabolic
balance,
hormonal
signaling,
reproductive
timing.
Specifically,
highlight
regulatory
interactions
sensors
(AMPK,
mTOR,
SIRT1
DLK1-Notch),
well
signals
(IGF-1,
kisspeptin,
leptin,
cortisol,
thyroid
sex
steroids),
which
together
orchestrate
life-history
traits,
including
growth
rates,
sexual
with
particular
emphasis
on
their
role
in
Furthermore,
consider
its
potential
coordinator
POL-related
processes,
such
telomere
dynamics
epigenetic
mechanisms,
within
broader
network.
By
integrating
insights
from
biology
eco-evolutionary
perspectives,
propose
future
directions
to
dissect
pathway’s
regulation
taxa.
Understanding
these
will
provide
new
perspectives
organisms
adaptively
adjust
strategies
response
variability.
