Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Molecules, Год журнала: 2023, Номер 28(20), С. 7209 - 7209

Опубликована: Окт. 21, 2023

The clinical relationship between diabetes and inflammation is well established. Evidence clearly indicates that disrupting oxidant-antioxidant equilibrium elevated lipid peroxidation could be a potential mechanism for chronic kidney disease associated with type 2 mellitus (T2DM). Under diabetic conditions, hyperglycemia, especially inflammation, increased reactive oxygen species generation are bidirectionally associated. Inflammation, oxidative stress, tissue damage believed to play role in the development of diabetes. Although exact underlying stress its impact on progression remains uncertain, hyperglycemia-inflammation-oxidative interaction plays significant onset vascular disease, hepatic injury, pancreas and, therefore, holds promise as therapeutic target. strongly use multiple antidiabetic medications fails achieve normal range glycated hemoglobin targets, signifying treatment-resistant Antioxidants polyphenols considered useful adjuvant therapy their anti-inflammatory effect antioxidant activity. We aimed analyze current major points reported preclinical, vivo, studies antioxidants prevention or treatment T2DM. Then, we will share our speculative vision future trials.

Язык: Английский

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Application of Luteolin in Neoplasms and Nonneoplastic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15995 - 15995

Опубликована: Ноя. 6, 2023

Researchers are amazed at the multitude of biological effects 3′,4′,5,7-tetrahydroxyflavone, more commonly known as luteolin, it simultaneously has antioxidant and pro-oxidant, well antimicrobial, anti-inflammatory, cancer-preventive, properties. The anticancer properties luteolin constitute a mosaic pathways due to which this flavonoid influences cancer cells. Not only is able induce apoptosis inhibit cell proliferation, but also suppresses angiogenesis metastasis. Moreover, succeeds in sensitization therapeutically induced cytotoxicity. Nevertheless, apart from its promising role chemoprevention, exhibits numerous potential utilizations patients with conditions other than neoplasms, include inflammatory skin diseases, diabetes mellitus, COVID-19. This review aims present multidimensionality luteolin’s impact on both neoplastic nonneoplastic diseases. When comes we intend describe complexity molecular mechanisms that underlay effectiveness, prove usefulness integrating therapy via analysis recent research breast, colon, lung cancer. Regarding emphasize importance researching areas such diabetology, virology, dermatology summarizes most important discoveries those fields regarding application.

Язык: Английский

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Lycopene: A Potent Antioxidant with Multiple Health Benefits

Journal of Nutrition and Metabolism, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Язык: Английский

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Antioxidant, Anti-Inflammatory, Anti-Diabetic, and Pro-Osteogenic Activities of Polyphenols for the Treatment of Two Different Chronic Diseases: Type 2 Diabetes Mellitus and Osteoporosis

Biomolecules, Год журнала: 2024, Номер 14(7), С. 836 - 836

Опубликована: Июль 11, 2024

Polyphenols are natural bioactives occurring in medicinal and aromatic plants food beverages of plant origin. Compared with conventional therapies, plant-derived phytochemicals more affordable accessible have no toxic side effects. Thus, pharmaceutical research is increasingly inclined to discover study new innovative molecules for the treatment several chronic human diseases, like type 2 diabetes mellitus (T2DM) osteoporosis. These pathological conditions characterized by a inflammatory state persistent oxidative stress, which interconnected lead development worsening these two health disorders. Oral nano delivery strategies been used improve bioavailability polyphenols allow exert their antioxidant, anti-inflammatory, anti-diabetic, pro-osteogenic biological activities vivo experimental models patients. commonly formulations nutraceuticals, can counteract detrimental effects T2DM osteoporosis pathologies. This review describes that protective against through modulation specific molecular markers pathways. could be as adjuvants, combination synthetic drugs, future develop therapeutic

Язык: Английский

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Identification of Oxidative-Stress-Reducing Plant Extracts from a Novel Extract Library—Comparative Analysis of Cell-Free and Cell-Based In Vitro Assays to Quantitate Antioxidant Activity

Antioxidants, Год журнала: 2024, Номер 13(3), С. 297 - 297

Опубликована: Фев. 28, 2024

Numerous underexplored plant species are believed to possess considerable potential in combating oxidative stress and its associated health impacts, emphasizing the need for a comprehensive methodological screening approach assess their antioxidant capacity. This study investigated 375 extracts, utilizing both cell-free cellular methods evaluate properties. Target-based capacity was evaluated by total phenolic content (TPC) ferric reducing power (FRAP) assays. Cell-based assays employed H2DCF-DA probe measure reactive oxygen (ROS) levels Griess assay quantify nitric oxide (NO) stressed Caco-2 RAW264.7 cells, respectively. The highest TPC FRAP values were found extracts of Origanum vulgare Fragaria × ananassa leaves. Several significantly reduced stress-induced ROS or NO at least 30%. Distinctive selectivity noted certain favoring significant reduction (e.g., Helianthus tuberosus extract), Prunus domestica subsp. Syriaca leaf extract). A strong correlation between moderate correlations results cell-based evident. These findings highlight great diversity underlying mechanisms, importance multifaceted assessment.

Язык: Английский

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A Comprehensive Review of Licorice: The Preparation, Chemical Composition, Bioactivities and Its Applications

The American Journal of Chinese Medicine, Год журнала: 2024, Номер 52(03), С. 667 - 716

Опубликована: Янв. 1, 2024

Licorice (Glycyrrhiza) is a medicinal and food homologue of perennial plants derived from the dried roots rhizomes genus Glycyrrhiza in legume family. In recent years, comprehensive utilization licorice resources has attracted people’s attention. It widely utilized to treat diseases, health products, production, other industrial applications. Furthermore, numerous bioactive components are found using advanced extraction processes, which mainly include polyphenols (flavonoids, dihydrostilbenes, benzofurans, coumarin), triterpenoids, polysaccharides, alkaloids, volatile oils, all have been reported possess variety pharmacological characteristics, including anti-oxidant, anti-inflammatory, antibacterial, antiviral, anticancer, neuroprotective, antidepressive, antidiabetic, antiparasitic, antisex hormone, skin effects, anticariogenic, antitussive, expectorant activities. Thereby, these compounds promote development novel more effective licorice-derived products. This paper reviews progress research on techniques, chemical composition, bioactivities, applications provide reference for further application different areas.

Язык: Английский

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The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

Microorganisms, Год журнала: 2024, Номер 12(4), С. 642 - 642

Опубликована: Март 23, 2024

Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed CUR possesses variety biological activities. Due to its anti-inflammatory and antioxidant properties, shows promise in treatment inflammatory bowel disease, while anti-obesity effects make it potential therapeutic agent management obesity. In addition, curcumin's ability prevent atherosclerosis cardiovascular benefits further expand application disease. Nevertheless, owing limited bioavailability CUR, difficult validate specific mechanism action diseases. However, restricted makes challenging confirm precise mode disease treatment. Recent research indicates oral intake curcumin may lead elevated levels residual gastrointestinal system, hinting at directly influence gut microbiota. Furthermore, ecological dysregulation microbiota has been shown critical pathogenesis human This review summarizes impact dysbiosis on host health various ways which modulates ameliorates diseases caused by through administration curcumin.

Язык: Английский

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Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors

Bioactive Materials, Год журнала: 2024, Номер 36, С. 376 - 412

Опубликована: Март 21, 2024

The treatment of digestive system tumors presents challenges, particularly in immunotherapy, owing to the advanced immune tolerance system. Nanomaterials have emerged as a promising approach for addressing these challenges. They provide targeted drug delivery, enhanced permeability, high bioavailability, and low toxicity. Additionally, nanomaterials target immunosuppressive cells reshape tumor microenvironment (TIME). Among various TIME, tumor-associated macrophages (TAMs) are most abundant play crucial role progression. Therefore, investigating modulation TAMs by is great significance. Here, we present comprehensive review utilization modulate gastric cancer, colorectal hepatocellular carcinoma, pancreatic cancer. We also investigated underlying mechanisms which treat Furthermore, this summarizes macrophage-derived tumors. Overall, research offers valuable insights into development tailored

Язык: Английский

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Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3233 - 3253

Опубликована: Июль 1, 2024

Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink other databases find the relevant literature last two decades. Using "gastric cancer", "stomach cancers", "flavonoid", "bioflavonoid", "2-Phenyl-Chromene" as keywords, were searched, then analyzed summarized mechanism flavonoids treatment GC. It was revealed that involves inhibiting growth, proliferation, invasion, metastasis, well inducing cell death through various processes such apoptosis, autophagy, ferroptosis, pyroptosis. Additionally, combining chemotherapeutic agents like 5-FU platinum can potentially reduce chemoresistance. Flavonoids also demonstrated enhanced activity when used combination products. Consequently, review proposes innovative perspectives for development anti-GC agents.

Язык: Английский

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Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review

Molecules, Год журнала: 2022, Номер 28(1), С. 281 - 281

Опубликована: Дек. 29, 2022

Metabolic syndrome (MetS) is a complex disease in which protein, fat, carbohydrates and other substances are metabolized disorderly way. Ferulic acid (FA) phenolic found many vegetables, fruits, cereals Chinese herbs that has strong effect on ameliorating MetS. However, no review summarized the mechanisms of FA treating This collected articles related to effects common symptoms MetS, such as diabetes, hyperlipidemia, hypertension obesity, from different sources involving Web Science, PubMed Google Scholar, etc. summarizes potential improving various metabolic disorders according articles. ameliorates diabetes via inhibition expressions PEPCK, G6Pase GP, upregulation GK GS, activation PI3K/Akt/GLUT4 signaling pathway. The decrease blood pressure endothelial function aortas RAAS. improvement lipid spectrum mediated suppression HMG-Co A reductase, by promoting ACSL1 expression regulation factors associated with metabolism. Furthermore, inhibits obesity upregulating MEK/ERK pathway, MAPK pathway AMPK inhibiting SREBP-1 expression. can be helpful for development an appreciable agent MetS treatment.

Язык: Английский

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