Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116909 - 116909

Опубликована: Июнь 8, 2024

Lung cancer is a prevalent malignant tumor and leading cause of cancer-related fatalities globally. However, current treatments all have limitations. Therefore, there an urgent need to identify readily available therapeutic agent counteract lung development progression. Luteolin flavonoid derived from vegetables herbs that possesses preventive effects on various cancers. With the goal providing new directions for treatment cancer, we review here recent findings luteolin so as provide ideas anti-lung drugs. The search focused studies published between January 1995 2024 explored use in cancer. A comprehensive literature was conducted SCOPUS, Google Scholar, PubMed, Web Science databases using keywords "luteolin" "lung cancer." By collecting previous literature, found has multiple mechanisms effects, including promotion apoptosis cells; inhibition cell proliferation, invasion metastasis; modulation immune responses. In addition, it can be used adjuvant radio-chemotherapy helps ameliorate complications. This summarizes structure, natural sources, physicochemical properties pharmacokinetics luteolin, focuses mechanism

Язык: Английский

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Research progress of stem cell therapy for endometrial injury

Materials Today Bio, Год журнала: 2022, Номер 16, С. 100389 - 100389

Опубликована: Авг. 9, 2022

Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing advantages cells from different sources, it believed that menstrual blood endometrial a good application prospect as source cells. However, clinical utility still by issues such colonization rates, long-term efficacy, tumor formation, storage transportation. This paper summarizes mechanism which repair clarifies material basis their effects four aspects: replacement damaged sites, paracrine effects, interaction with growth factors, other targets. According pathological characteristics requirements intrauterine adhesion (IUA), research work solve above problems aspects functional bioscaffold preparation multi-functional platform construction also summarized. From perspective scaffold materials component functions, review will provide reference comprehensively optimizing

Язык: Английский

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Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Янв. 19, 2024

Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and radiotherapy for head neck cancer can cause dry mouth, which increases the risk of disorders such as periodontitis, taste disorders, pain burning sensations in dental caries, dramatically reduces quality life patients. To date, treatment SGH is still aimed at relieving patients’ clinical symptoms improving their life, not able to repair regenerate damaged salivary glands. Pluripotent stem cells (PSCs), including embryonic (ESCs), induced pluripotent (iPSCs), extended (EPSCs), are an emerging source cellular therapies that capable unlimited proliferation differentiation into all three germ layers. In recent years, immunomodulatory tissue regenerative effects PSCs, derived cells, paracrine products these have received increasing attention demonstrated promising therapeutic some preclinical studies targeting SGH. This review outlined etiologies available treatments The existing efficacy potential role summarized, with a focus on PSC-derived stem/progenitor (SGS/PCs) mesenchymal (MSCs). this Review, we provide conceptual outline our current understanding PSCs-based therapy its importance treatment, may inform serve design future studies.

Язык: Английский

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Hypoxia contributes to the early stage progression of necrotizing sialometaplasia

American Journal Of Pathology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Necrotizing sialometaplasia (NSM) is a non-neoplastic lesion listed in the WHO classification of Head and Neck Tumours. In early NSM lesion, there infarction necrosis acinar cells squamous metaplasia salivary ducts occurs as matures. Differentiation from cell carcinoma other malignancies sometimes required clinically histopathologically. Local hypoxia caused by trauma vascular compromise proposed etiology NSM. However, mechanisms underlying pathogenesis are unclear. This study focused on stages Histopathological observations revealed that region showing contained myoepithelial with reticular arrangement. Hypoxic vitro experiments using mouse gland organoids basal were more tolerant to than cells. Moreover, residual hypoxia-tolerant expressed transforming growth factor β3 (TGFB3), which plays critical role proliferation metaplasia. Organoid have also replicated process during resolution hypoxia. Thus, this demonstrated possible based results histopathological experimental observations.

Язык: Английский

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Receptor-Regulated Smads (R-Smads) in the Liver Fluke Fasciola gigantica: Characterization, Comparative Sequence Analysis, and Life Stage-Specific Expression

Acta Tropica, Год журнала: 2025, Номер unknown, С. 107603 - 107603

Опубликована: Март 1, 2025

Язык: Английский

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Cadherin Signaling in Cancer and Autoimmune Diseases

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(24), С. 13358 - 13358

Опубликована: Дек. 12, 2021

Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent on the cellular context and signaling. Cadherin regulation reflects interplay between fundamental processes, including morphogenesis, proliferation, programmed cell death, surface organization of receptors, cytoskeletal organization, trafficking. The variety molecular mechanisms functions regulated by cadherins suggests we have only scratched in terms clarifying mediated these versatile proteins. Altered expression closely connected with tumorigenesis, epithelial–mesenchymal transition (EMT)-dependent fibrosis, autoimmunity. We review current understanding how contribute to human health disease, considering cadherin involvement diseases progression, as well clinical significance therapeutic targets.

Язык: Английский

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E-Cadherin Signaling in Salivary Gland Development and Autoimmunity

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(8), С. 2241 - 2241

Опубликована: Апрель 17, 2022

E-cadherin, the major epithelial cadherin, is located in regions of cell–cell contact known as adherens junctions. E-cadherin contributes to maintenance integrity through homophylic interaction; cytoplasmic tail directly binds catenins, forming a dynamic complex that regulates several intracellular signal transduction pathways, including epithelial-to-mesenchymal transition (EMT). Recent progress uncovered novel and critical role for this adhesion molecule salivary gland (SG) development SG diseases. We summarize structure regulation gene transcript view remarkable protein morphogenesis, focusing, second part review, on altered expression EMT-mediated autoimmunity.

Язык: Английский

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Towards a Unified Approach in Autoimmune Fibrotic Signalling Pathways

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 9060 - 9060

Опубликована: Май 21, 2023

Autoimmunity is a chronic process resulting in inflammation, tissue damage, and subsequent remodelling organ fibrosis. In contrast to acute inflammatory reactions, pathogenic fibrosis typically results from the reactions characterizing autoimmune diseases. Despite having obvious aetiological clinical outcome distinctions, most fibrotic disorders have common persistent sustained production of growth factors, proteolytic enzymes, angiogenic fibrogenic cytokines, which together stimulate deposition connective elements or epithelial mesenchymal transformation (EMT) that progressively remodels destroys normal architecture leading failure. its enormous impact on human health, there are currently no approved treatments directly target molecular mechanisms The primary goal this review discuss recent identified diseases characterized by evolution with aim identify possible unique fibrogenesis might be exploited development effective antifibrotic therapies.

Язык: Английский

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Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(20), С. 11152 - 11152

Опубликована: Окт. 15, 2021

Idiopathic pulmonary fibrosis (IPF) is characterized by fibrotic change in alveolar epithelial cells and leads to the irreversible deterioration of function. Transforming growth factor-beta 1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) type 2 lung contributes excessive collagen deposition plays an important role IPF. Atractylodin (ATL) a kind herbal medicine that has been proven protect intestinal inflammation attenuate acute injury. Our study aimed determine whether EMT played crucial pathogenesis can be utilized as therapeutic target ATL treatment mitigate To address this topic, we took two steps investigate: 1. Utilization anin vitro model treating (A549 cells) with TGF-β1 followed for elucidating underlying pathways, including Smad2/3 hyperphosphorylation, mitogen-activated protein kinase (MAPK) pathway overexpression, Snail Slug upregulation, loss E-cadherin. vivo injury bleomycin on mice demonstrate effectiveness, such as, less lower E-cadherin expression. In conclusion, attenuates TGF-β1-induced A549 bleomycin-induced mice.

Язык: Английский

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Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets

Cytokine, Год журнала: 2023, Номер 170, С. 156351 - 156351

Опубликована: Авг. 30, 2023

The cytokine known as transforming growth factor (TGF) is essential for cell development, differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor it a key signaling pathway BC spread. A recently identified family of ncRNAs lncRNAs has received great deal effort an important regulator many cellular processes, including transcription genes, chromatin remodeling, progression the cycle, posttranscriptional processing. Furthermore, both serve early-stage biomarkers diagnosis prognosis also play significant role drug resistance. According to recent studies, regulate by modulating its cofactors However, particular functions controlling are not well understood yet. This review explores lncRNAs' functional properties suppressors oncogenes regulation with focus on dysregulated signaling. Further, we emphasize roles discover new treatment strategies better comprehend fundamental pathways.

Язык: Английский

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