Molecular Biology Reports, Год журнала: 2024, Номер 51(1)
Опубликована: Май 10, 2024
Язык: Английский
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Май 31, 2024
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the brain or spinal cord that gradually lose function, eventually leading to cell death. Upon examination affected tissue, pathological changes reveal a loss synapses, misfolded proteins, and activation immune cells—all indicative disease progression—before severe clinical symptoms become apparent. Early detection NDs is crucial for potentially administering targeted medications may delay advancement. Given their complex pathophysiological features diverse symptoms, there pressing need sensitive effective diagnostic methods NDs. Biomarkers such as microRNAs (miRNAs) have been identified potential tools detecting these diseases. We explore pivotal role miRNAs in context NDs, focusing on Alzheimer’s disease, Parkinson’s Multiple sclerosis, Huntington’s Amyotrophic Lateral Sclerosis. The review delves into intricate relationship between aging highlighting structural functional alterations implications development. It elucidates how RNA-binding proteins implicated pathogenesis underscores importance investigating expression function aging. Significantly, exert substantial influence post-translational modifications (PTMs), impacting not just nervous system but wide array tissues types well. Specific found target involved ubiquitination de-ubiquitination processes, which play significant regulating protein stability. discuss link miRNA, PTM, Additionally, discusses significance biomarkers early detection, offering insights strategies.
Язык: Английский
Процитировано
5
Journal of Neurochemistry, Год журнала: 2025, Номер 169(3)
Опубликована: Март 1, 2025
ABSTRACT Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss and dysfunction, leading to significant cognitive motor impairments. The disruption of the blood–brain barrier (BBB) integrity, a key regulator central nervous system homeostasis, emerges as critical factor in pathogenesis these disorders. Accumulating evidence implicates non‐coding RNAs, particularly microRNAs (miRNAs) long RNAs (lncRNAs), BBB regulation. However, intricate network governing dysfunction consequent neurodegeneration remains obscure. This systematic review maps convergent microRNA networks Alzheimer's, Parkinson's, multiple sclerosis, unveiling their putative roles modulation. We analyzed data from 11 peer‐reviewed clinical studies, identifying miRNAs such hsa‐miR‐155, hsa‐miR‐22, hsa‐miR‐146a, hsa‐miR‐100‐3p, hsa‐miR‐182‐5p regulators permeability inflammatory responses. Enrichment analysis revealed that modulate pathways related inflammation, oxidative stress, survival. Our also uncovered extensive interactions between transcription factors like JUN, RELA, STAT3, TP53, well lncRNAs MALAT1, NEAT1, NORAD, SNHG16. These highlight complex regulatory involving miRNA sponging chromatin remodeling, which may play crucial maintaining integrity. analyses underscore importance miRNA‐mediated function offer insights into potential therapeutic targets for NDs. image
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0
Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
FEBS Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
MicroRNAs (miRNAs) are a prominent class of small non‐coding RNAs that control gene expression. This comprehensive review explores the intricate roles miRNAs in metabolism and immunity, as well emerging field immunometabolism. The core this work delves into functional regulatory capabilities miRNAs, examining their complex influence on glucose lipid metabolism, pivotal shaping T‐cell development function. Specifically, addresses how orchestrate interaction between cellular metabolic processes immune responses, underscoring essential nature these molecules maintaining homeostasis. Finally, we examine role Artificial Intelligence (AI) miRNA research, focusing machine learning techniques revolutionizing identification validation potential biomarkers. By integrating diverse aspects, underscores multifaceted biological significant advancing biomedical research clinical applications.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2021, Номер 10(7), С. 1733 - 1733
Опубликована: Июль 8, 2021
Although extracellular vesicles (EVs) were initially relegated to a waste disposal role, nowadays, they have gained multiple fundamental functions working as messengers in intercellular communication well exerting active roles physiological and pathological processes. Accumulating evidence proves the involvement of EVs many diseases, including those central nervous system (CNS), such sclerosis (MS). Indeed, these membrane-bound particles, produced any type cell, carry release vast range bioactive molecules (nucleic acids, proteins, lipids), conferring genotypic phenotypic changes recipient cell. This means that not only per se but their content, especially, could reveal new candidate disease biomarkers and/or therapeutic agents. review is intended provide an overview regarding current knowledge about EVs’ MS, analyzing potential versatility tool source biomarkers.
Язык: Английский
Процитировано
28
Molecular Biology Reports, Год журнала: 2023, Номер 50(12), С. 9971 - 9984
Опубликована: Окт. 28, 2023
Язык: Английский
Процитировано
11
Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14
Опубликована: Окт. 4, 2022
COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with broad spectrum of clinical manifestations. The evolving scientific evidence demonstrates that the frequency cognitive impairment after high it crucial to explore more research implement proper diagnostic treatment strategies. Several central nervous system complications have been reported comorbidities COVID-19. changes in function associated neurodegenerative diseases develop slowly over time are only diagnosed at an already advanced stage molecular pathology. Hence, understanding common links between will broaden our knowledge help strategizing prognostic therapeutic approaches. present review focuses on diverse highlight importance major circulating biomarkers microRNAs (miRNAs) progression severity. literature analysis showed proteins function, such Glial fibrillary acidic protein, neurofilament light chain, p-tau 181, Ubiquitin C-terminal hydrolase L1, S100 calcium-binding protein B, Neuron-specific enolase various inflammatory cytokines, were significantly altered patients. Furthermore, among miRNAs pivotal roles diseases, miR-146a, miR-155, Let-7b, miR-31, miR-16 miR-21 shown significant dysregulation Thus consolidates important findings from numerous studies unravel underlying mechanism neurological sequelae possible association circulatory biomarkers, which may serve predictors targets future research.
Язык: Английский
Процитировано
17
Experimental and Molecular Pathology, Год журнала: 2024, Номер 137, С. 104903 - 104903
Опубликована: Май 20, 2024
Multiple sclerosis (MS) is a chronic demyelinating autoimmune neurodegenerative disorder for which no specific blood biomarker available. MicroRNAs (miRNAs) have been investigated their diagnostic potential in MS. However, MS-associated miRNAs are rarely replicated different MS populations, thus impeding use clinical testing. Here, we evaluated the fold expression of seven reported associated with incidence and characteristics 76 patients 75 healthy control plasma samples. We found miR-23a-3p to be upregulated relapsing-remitting (RRMS), while miR-326 was downregulated. MiR-150-5p -320a-3p were significantly downregulated secondary progressive (SPMS) compared RRMS. High disability low miR-320a-3p, whereas BDNF levels upregulation miR-150-5p downregulation total cohort. MiR-23a-3p showed significant sensitivity, specificity, accuracy RRMS diagnosis. In addition, miR-320a-3p had comparable test performance metrics distinguishing SPMS from Therefore, there including an miRNA panel. Moreover, shown that could novel conversion biomarkers. The these diagnosis prognosis warrants further investigation.
Язык: Английский
Процитировано
3
Egyptian Journal of Medical Human Genetics, Год журнала: 2024, Номер 25(1)
Опубликована: Июль 2, 2024
Abstract Background Small RNA molecules known as microRNAs (miRNAs) regulate gene expression during the post-translational steps. miRNAs are essential for many physiological processes, such cell division, growth, and proliferation, well development metabolism. Aims To review developments in investigations on miR-155 miR-146a possible biomarkers multiple sclerosis (MS) disease diagnosis prognosis. Methods A comprehensive analysis of available literature was carried out by searching databases including PubMed, Scopus, Web Science papers published between 2011 2023 years. Only original articles written English language were considered inclusion this review. Results total 29 studies initially identified, with 14 meeting criteria. Conclusion The present study underscores crucial role microRNAs, particularly miR-146a, etiology progression (MS). Through an extensive literature, we have found compelling evidence linking aberrations function these to MS pathogenesis. Specifically, our synthesis suggests that hold promise valuable both prognosis MS. Despite challenges posed heterogeneity subtypes, non-invasive accessibility various bodily fluids, serum, peripheral blood, cerebrospinal fluid, extracellular vesicles, presents a promising avenue robust diagnostic prognostic tools. By elucidating intricate roles MS, findings contribute advancing understanding mechanisms pave way more effective therapeutic strategies.
Язык: Английский
Процитировано
3